Genetic analysis of the dihydrofolate reductase-thymidylate synthase gene from geographically diverse isolates of Plasmodium malariae

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 10, 2007, Pages 3523-3530

  Tanomsing, Naowarat ^a   Imwong, Mallika ^a   Pukrittayakamee, Sasithon ^a   Chotivanich, Kesinee ^a   Looareesuwan, Sornchai ^a   Mayxay, Mayfong ^b   Dolecek, Christiane ^c   Tran, Tinh Hien ^c   Do Rosario, Virgilio E ^d   Arez, Ana Paula ^d   Michon, Pascal ^e   Snounou, Georges ^f   White, Nicholas J ^a,g   Day, Nicholas P J ^a,g  

^a MAHIDOL UNIVERSITY   (Thailand)

^b MAHOSOT HOSPITAL   (Laos)

^c OXFORD UNIVERSITY CLINICAL RESEARCH UNIT   (Viet Nam)

^d INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^e PAPUA NEW GUINEA INSTITUTE OF MEDICAL RESEARCH   (Papua New Guinea)

^f MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^g UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; PYRIMETHAMINE; THYMIDYLATE SYNTHASE;

AFRICA; ARTICLE; DHFR GENE; DISEASE TRANSMISSION; ENDEMIC DISEASE; GENE; GENE MUTATION; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HUMAN; IC 50; IN VITRO STUDY; MALARIA; MORBIDITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE ISOLATION; PLASMODIUM; PLASMODIUM BRASILIANUM; PLASMODIUM FALCIPARUM; PLASMODIUM MALARIAE; PLASMODIUM VIVAX; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; WILD TYPE;

EID: 34948911147     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00234-07     Document Type: Article

References (39)

1. Baird, J. K., E. Caneta-Miguel, S. Masbar, D. G. Bustos, J. A. Abrenica, A. V. Layawen, J. M. Calulut, B. Leksana, and F. S. Wignall. 1996. Survey of resistance to chloroquine of falciparum and vivax malaria in Palawan, The Philippines. Trans. R. Soc. Trop. Med. Hyg. 90:413-414.
2. Baird, J. K., B. Leksana, S. Masbar, D. J. Fryauff, M. A. Sutanihardja, Suradi, F. S. Wignall, and S. L. Hoffman. 1997. Diagnosis of resistance to chloroquine by Plasmodium vivax: timing of recurrence and whole blood chloroquine levels. Am. J. Trop. Med. Hyg. 56:621-626.
3. Brockman, A., R. N. Price, M. van Vugt, D. G. Heppner, D. Walsh, P. Sookto, T. Wimonwattrawatee, S. Looareesuwan, N. J. White, and F. Nosten. 2000. Plasmodium falciparum antimalarial drug susceptibility on the north-western border of Thailand during five years of extensive use of artesunate-mefloquine. Trans. R. Soc. Trop. Med. Hyg. 94:537-544.
4. Childs, G. E., L. Pang, T. Wimonwattrawatee, N. Pooyindee, A. Nanakorn, S. Limchitee, and H. K. Webster. 1987. In vitro mefloquine resistance of Plasmodium falciparum isolated from the Burmese border region of Thailand. Southeast Asian J. Trop. Med. Public Health 18:438-443.
5. Chotivanich, K., R. Udomsangpetch, W. Chierakul, P. N. Newton, R. Ruangveerayuth, S. Pukrittayakamee, S. Looareesuwan, and N. J. White. 2004. In vitro efficacy of antimalarial drugs against Plasmodium vivax on the western border of Thailand. Am. J. Trop. Med. Hyg. 70:395-397.
6. Coatney, G. R., W. E. Collins, M. Warren, and P. G. Contacos. 1971. The primate malarias. U.S. Government Printing Office, Washington DC.
7. Cowman, A. F., M. J. Morry, B. A. Biggs, G. A. Cross, and S. J. Foote. 1988. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 85:9109-9113.
8. de Pecoulas, P. E., R. Tahar, T. Ouatas, A. Mazabraud, and L. K. Basco. 1998. Sequence variations in the Plasmodium vivax dihydrofolate reductase-thymidylate synthase gene and their relationship with pyrimethamine resistance. Mol. Biochem. Parasitol. 92:265-273.
9. de Pecoulas, P. E., R. Tahar, P. Yi, K. H. Thai, and L. K. Basco. 2004. Genetic variation of the dihydrofolate reductase gene in Plasmodium vivax in Snoul, northeastern Cambodia. Acta Trop. 92:1-6.
10. Eidin de Pecoulas, P., L. K. Basco, R. Tahar, T. Ouatas, and A. Mazabraud. 1998. Analysis of the Plasmodium vivax dihydrofolate reductase-thymidylate synthase gene sequence. Gene 211:177-185.
11. Escalante, A. A., and F. J. Ayala. 1994. Phylogeny of the malarial genus Plasmodium, derived from rRNA gene sequences. Proc. Natl. Acad. Sci. USA 91:11373-11377.
12. Escalante, A. A., E. Barrio, and F. J. Ayala. 1995. Evolutionary origin of human and primate malarias: evidence from the circumsporozoite protein gene. Mol. Biol. Evol. 12:616-626.
13. Fandeur, T., B. Volney, C. Peneau, and B. de Thoisy. 2000. Monkeys of the rainforest in French Guiana are natural reservoirs for P. brasilianum/P. malariae malaria. Parasitology 120:11-21.
14. Felsenstein, J. 1988. Phylogenies from molecular sequences: inference and reliability. Annu. Rev. Genet. 22:521-565.
15. Garrett, C. E., J. A. Coderre, T. D. Meek, E. P. Garvey, D. M. Claman, S. M. Beverley, and D. V. Santi. 1984. A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa. Mol. Biochem. Parasitol. 11:257-265.
16. Hastings, I. M., W. M. Watkins, and N. J. White. 2002. The evolution of drug-resistant malaria: the role of drug elimination half-life. Philos. Trans. R. Soc. Lond. B 357:505-519.
17. Imwong, M., S. Pukrittakayamee, S. Looareesuwan, G. Pasvol, J. Poirreiz, N. J. White, and G. Snounou. 2001. Association of genetic mutations in Plasmodium vivax dhfr with resistance to sulfadoxine-pyrimethamine: geographical and clinical correlates. Antimicrob. Agents Chemother. 45:3122-3127.
18. Imwong, M., S. Pukrittayakamee, L. Renia, F. Letourneur, J. P. Charlieu, U. Leartsakulpanich, S. Looareesuwan, N. J. White, and G. Snounou. 2003. Novel point mutations in the dihydrofolate reductase gene of Plasmodium vivax: evidence for sequential selection by drug pressure. Antimicrob. Agents Chemother. 47:1514-1521.
19. Jongwutiwes, S., C. Putaporntip, T. Iwasaki, T. Sata, and H. Kanbara. 2004. Naturally acquired Plasmodium knowlesi malaria in human, Thailand. Emerg. Infect. Dis. 10:2211-2213.
20. Klinkaewnarong, W., T. Chongsuphajaisiddhi, A. Sabchareon, and C. R. Brockelman. 1985. In vitro sensitivity of Plasmodium falciparum to sulfadoxine and pyrimethamine. Southeast Asian J. Trop. Med. Public Health 16: 296-301.
21. Liu, Q., S. Zhu, S. Mizuno, M. Kimura, P. Liu, S. Isomura, X. Wang, and F. Kawamoto. 1998. Sequence variation in the small-subunit rRNA gene of Plasmodium malariae and prevalence of isolates with the variant sequence in Sichuan, China. J. Clin. Microbiol. 36:3378-3381.
22. Lupascu, G., A. Bossie-Agavriloaei, M. Smolinski, E. Ballif Negulici, P. Constantinesco, T. Isfan, D. Petrea, V. Mazilu, and V. Roman. 1963. Le problème des infectionsà P. malariae et les programmes d'éradication du paludisme. Arch. Roum. Pathol. Exp. Microbiol. 22:333-348.
23. Maguire, J. D., I. W. Sumawinata, S. Masbar, B. Laksana, P. Prodjodipuro, I. Susanti, P. Sismadi, N. Mahmud, M. J. Bangs, and J. K. Baird. 2002. Chloroquine-resistant Plasmodium malariae in south Sumatra, Indonesia. Lancet 360:58-60.
24. Mayxay, M., S. Pukrittayakamee, P. N. Newton, and N. J. White. 2004. Mixed-species malaria infections in humans. Trends Parasitol. 20:233-240.
25. Peterson, D. S., W. K. Milhous, and T. E. Wellems. 1990. Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria. Proc. Natl. Acad. Sci. USA 87:3018-3022.
26. Plowe, C. V., J. F. Cortese, A. Djimde, O. C. Nwanyanwu, W. M. Watkins, P. A. Winstanley, J. G. Estrada-Franco, R. E. Mollinedo, J. C. Avila, J. L. Cespedes, D. Carter, and O. K. Doumbo. 1997. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase and epidemiologic patterns of pyrimethamine-sulfadoxine use and resistance. J. Infect. Dis. 176:1590-1596.
27. Pukrittayakamee, S., A. Chantra, J. A. Simpson, S. Vanijanonta, R. Clemens, S. Looareesuwan, and N. J. White. 2000. Therapeutic responses to different antimalarial drugs in vivax malaria. Antimicrob. Agents Chemother. 44:1680-1685.
28. Pukrittayakamee, S., M. Imwong, S. Looareesuwan, and N. J. White. 2004. Therapeutic responses to antimalarial and antibacterial drugs in vivax malaria. Acta Trop. 89:351-356.
29. Qari, S. H., Y. P. Shi, N. J. Pieniazek, W. E. Collins, and A. A. Lal. 1996. Phylogenetic relationship among the malaria parasites based on small subunit rRNA gene sequences: monophyletic nature of the human malaria parasite, Plasmodium falciparum. Mol. Phylogenet. Evol. 6:157-165.
30. Scopel, K. K., C. J. Fontes, A. C. Nunes, M. F. Horta, and E. M. Braga. 2004. High prevalence of Plasmodium malariae infections in a Brazilian Amazon endemic area (Apiacas - Mato Grosso State) as detected by polymerase chain reaction. Acta Trop. 90:61-64.
31. Singh, B., L. Kim Sung, A. Matusop, A. Radhakrishnan, S. S. Shamsul, J. Cox-Singh, A. Thomas, and D. J. Conway. 2004. A large focus of naturally acquired Plasmodium knowlesi infections in human beings. Lancet 363:1017-1024.
32. Snounou, G., L. Pinheiro, A. Goncalves, L. Fonseca, F. Dias, K. N. Brown, and V. E. do Rosario. 1993. The importance of sensitive detection of malaria parasites in the human and insect hosts in epidemiological studies, as shown by the analysis of field samples from Guinea Bissau. Trans. R. Soc. Trop. Med. Hyg. 87:649-653.
33. Snounou, G., and B. Singh. 2002. Nested PCR analysis of Plasmodium parasites. Methods Mol. Med. 72:189-203.
34. Snounou, G., S. Viriyakosol, X. P. Zhu, W. Jarra, L. Pinheiro, V. E. do Rosario, S. Thaithong, and K. N. Brown. 1993. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. Mol. Biochem. Parasitol. 61:315-320.
35. Snounou, G., and N. J. White. 2004. The co-existence of Plasmodium: sidelights from falciparum and vivax malaria in Thailand. Trends Parasitol. 20:333-339.
36. Van Goor, W. T., J. G. Lodens, and J. Alier Gomez. 1950. Clinical prophylaxis with proguanil and nivaquine in a community in Java. Doc. Neerl. Indones. Morb. Trop. 2:341-349.
37. Vinetz, J. M., J. Li, T. F. McCutchan, and D. C. Kaslow. 1998. Plasmodium malariae infection in an asymptomatic 74-year-old Greek woman with splenomegaly. N. Engl. J. Med. 338:367-371.
38. Young, M. D. 1957. Resistance of Plasmodium malariae to pyrimethamine (daraprim). Am. J. Trop. Med. Hyg. 6:621-624.
39. Zolg, J. W., J. R. Plitt, G. X. Chen, and S. Palmer. 1989. Point mutations in the dihydrofolate reductase-thymidylate synthase gene as the molecular basis for pyrimethamine resistance in Plasmodium falciparum. Mol. Biochem. Parasitol. 36:253-262.