GriC and GriD constitute a carboxylic acid reductase involved in grixazone biosynthesis in Streptomyces griseus

Journal of Antibiotics

Volumn 60, Issue 6, 2007, Pages 380-387

  Suzuki, Hirokazu ^a   Ohnishi, Yasuo ^a   Horinouchi, Sueharu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

3 amino 4 hydroxybenzoic acid; Benzoate transporter; Bioconversion; Biosynthesis; Carboxylic acid reductase; Grixazone; Streptomyces griseus

Indexed keywords

3 ACETYLAMINO 4 HYDROXYBENZOIC ACID; 3 AMINO 4 HYDROXYBENZALDEHYDE; 3 AMINO 4 HYDROXYBENZOIC ACID; ACYLTRANSFERASE; ADENOSINE PHOSPHATE; ALDEHYDE; ALDEHYDE DEHYDROGENASE; BACTERIAL ENZYME; BENZALDEHYDE DERIVATIVE; BENZOIC ACID; BENZOIC ACID DERIVATIVE; BINDING PROTEIN; CARBOXYLIC ACID; CARBOXYLIC ACID REDUCTASE; GRIXAZONE; PIGMENT; UNCLASSIFIED DRUG; 1 ((2 (ACETYLAMINO) 2 CARBOXYETHYL)THIO) 2 AMINO 3 OXO 8 CARBOXYL 3H PHENOXIAZINE; 1 ((2 (ACETYLAMINO) 2 CARBOXYETHYL)THIO) 2 AMINO 3 OXO 8 FORMYL 3H PHENOXIAZINE; 1-((2-(ACETYLAMINO)-2-CARBOXYETHYL)THIO)-2-AMINO-3-OXO-8-CARBOXYL-3H-PHENOXIAZINE; 1-((2-(ACETYLAMINO)-2-CARBOXYETHYL)THIO)-2-AMINO-3-OXO-8-FORMYL-3H-PHENOXIAZINE; 3-AMINO-4-HYDROXYBENZOIC ACID; AMINOBENZOIC ACID DERIVATIVE; BACTERIAL DNA; OXAZINE DERIVATIVE; OXIDOREDUCTASE;

ACETYLATION; AMINO ACID SEQUENCE; ARTICLE; BACTERIAL GENE; BIOTRANSFORMATION; CELL MUTANT; DRUG SYNTHESIS; GENE CLUSTER; GENE DISRUPTION; GENE OVEREXPRESSION; GRIC GENE; GRID GENE; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; STREPTOMYCES GRISEUS; CHEMISTRY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MULTIGENE FAMILY;

STREPTOMYCES GRISEUS;

AMINOBENZOIC ACIDS; DNA, BACTERIAL; MULTIGENE FAMILY; MUTAGENESIS, INSERTIONAL; OXAZINES; OXIDOREDUCTASES; STREPTOMYCES GRISEUS;

EID: 34948898637     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2007.52     Document Type: Article

References (20)

1. Horinouchi S. Mining and polishing of the treasure trove in the bacterial genus Streptomyces. Biosci Biotechnol Biochem 71: 283-299 (2007)
2. Axcel Z, Sabine B-M, Susanne G, Hartmut V, Gerhard S. Preparation of phenoxazinone derivatives by fermentation with Streptomyces DSM 3813 and their use as parasiticides. European Patent EP260486 (1988)
3. Ohnishi Y, Furusho Y, Higashi T, Chun H-K, Furihata K, Sakuda S, Horinouchi S. Structures of grixazone A and B, A-factor-dependent yellow pigments produced under phosphate depletion by Streptomyces griseus. J Antibiot 57: 218-223 (2004)
4. Higashi T, Iwasaki Y, Ohnishi Y, Horinouchi S. A-factor and phosphate-depletion signals are transmitted to the grixazone biosynthesis genes via the pathway-specific transcriptional activator GriR. J Bacteriol 189: 3515-3524 (2007)
5. 4 primary metabolites by two enzymes. J Biol Chem 281: 36944-36951 (2006)
6. Suzuki H, Furusho Y, Higashi T, Ohnishi Y, Horinouchi S. A novel o-aminophenol oxidase responsible for formation of the phenoxazinone chromophore of grixazone. J Biol Chem 281: 824-833 (2006)
7. Giddens SR, Feng Y, Mahanty HK. Characterization of a novel phenazine antibiotic gene cluster in Erwinia herbicola Eh1087. Mol Microbiol 45: 769-783 (2002)
8. Núñez LE, Méndez C, Braña AF, Blanco G, Salas JA. The biosynthetic gene cluster for the β-lactam carbapenem thienamycin in Streptomyces cattleya. Chem Biol 10: 301-311 (2003)
9. Suzuki H, Ohnishi Y, Horinouchi S. Arylamine N- acetyltransferase responsible for acetylation of 2-aminophenols in Streptomyces griseus. J Bacteriol 189: 2155-2159 (2007)
10. Hopwood DA, Bibb MJ, Chater KF, Kieser T, Bruton CJ, Kieser HM, Lydiate DJ, Smith CP, Ward JM, Schrempf H. Genetic manipulation of Streptomyces: a laboratory manual. The John Innes Foundation, Norwich, United Kingdom (1985)
11. Katz E, Thompson CJ, Hopwood DA. Cloning and expression of the tyrosinase gene from Streptomyces antibioticus in Streptomyces lividans. J Gen Microbiol 129: 2703-2714 (1983)
12. He A, Li T, Daniels L, Fotheringham I, Rosazza JPN. Nocardia sp. carboxylic acid reductase: cloning, expression, and characterization of a new aldehyde oxidoreductase family. Appl Environ Microbiol 70: 1874-1881 (2004)
13. Venkitasubramanian P, Daniels L, Rosazza JPN. Reduction of carboxylic acids by Nocardia aldehyde oxidoreductase requires a phosphopantetheinylated enzyme. J Biol Chem 282: 478-485 (2007)
14. Bentley SD, Chater KF, Cerdeño-Tárraga A-M, Challis GL, Thomson NR, James KD, Harris DE, Quail MA, Kieser H, Harper D, Bateman A, Brown S, Chandra G, Chen CW, Collins M, Cronin A, Fraser A, Goble A, Hidalgo J, Hornsby T, Howarth S, Huang C-H, Kieser T, Larke L, Murphy L, Oliver K, O'Neil S, Rabbinowitsch E, Rajandream M-A, Rutherford K, Rutter S, Seeger K, Saunders D, Sharp S, Squares R, Squares S, Taylor K, Warren T, Wietzorrek A, Woodward J, Barrell BG, Parkhill J, Hopwood DA. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417: 141-147 (2002)
15. Li L, Bannantine JP, Zhang Q, Amonsin A, May BJ, Alt D, Banerji N, Kanjilal S, Kapur V. The complete genome sequence of Mycobacterium avium subspecies paratuberculosis. Proc Natl Acad Sci USA 102: 12344-12349 (2005)
16. Ueda K, Yamashita A, Ishikawa J, Shimada M, Watsuji T, Morimura K, Ikeda H, Hattori M, Beppu T. Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism. Nucleic Acids Res 32: 4937-4944 (2004)
17. Duchaud E, Rusniok C, Frangeul L, Buchrieser C, Givaudan A, Taourit S, Bocs S, Boursaux-Eude C, Chandler M, Charles J-F, Dassa E, Derose R, Derzelle S, Freyssinet G, Gaudriault S, Médigue C, Lanois A, Powell K, Siguier P, Vincent R, Wingate V, Zouine M, Glaser P, Boemare N, Danchin A, Kunst F. The genome sequence of the entomopathogenic bacterium Photorhabdus luminescens. Nat Biotechnol 21: 1307-1313 (2003)
18. Meighem EA. Bacterial bioluminescence: organization, regulation, and application of the lux genes. FASEB J 7: 1016-1022 (1993)
19. Pao SS, Paulsen IT, Saier Jr MH. Major facilitator superfamily. Microbiol Mol Biol Rev 62: 1-34 (1998)
20. Priefert H, Rabenhorst J, Steinbüchel A. Biotechnological production of vanillin. Appl Microbiol Biotechnol 56: 296-314 (2001)