Biophysical models in ion beam radiotherapy

Advances in Space Research

Volumn 40, Issue 9, 2007, Pages 1381-1391

  Scholz, Michael ^a   Elsässer, Thilo ^a  

^a GSI HELMHOLTZZENTRUM FÜR SCHWERIONENFORSCHUNG GMBH   (Germany)

Author keywords

Biophysical model; High LET; Ion beam radiotherapy; RBE

Indexed keywords

DATA REDUCTION; ION BEAMS; PARAMETER ESTIMATION; PHYSIOLOGICAL MODELS; TUMORS;

BIOPHYSICAL MODELS; ION BEAM RADIOTHERAPY; RELATIVE BIOLOGICAL EFFECTIVENESS (RBE);

RADIOTHERAPY;

EID: 34948882369     PISSN: 02731177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.asr.2007.02.066     Document Type: Article

References (43)

1. Blakely, E.A. Biology of BEVALAC beams, in: Skarsgard, L.D. (Ed.), Pion and Heavy Ion Radiotherapy: Pre-Clinical and Clinical Studies. Elsevier Science Publishing Co, Inc., New York, pp. 229-250, 1982.
2. Brons S., Taucher-Scholz G., Scholz M., and Kraft G. A track structure model for simulation of strand breaks in plasmid DNA after heavy ion irradiation. Radiat. Environ. Biophys. 42 (2003) 63-72
3. Butts J.J., and Katz R. Theory of RBE for heavy ion bombardment of dry enzymes and viruses. Radiat. Res. 30 (1967) 855-871
4. Cucinotta F.A., Dicello J.F., Nikjoo H., and Cherubini R. Computational model of the modulation of gene expression following DNA damage. Radiat. Prot. Dosim. 99 (2002) 85-90
5. Curtis S.B. Lethal and potentially lethal lesions induced by radiation - a unified repair model. Radiat. Res. 106 (1986) 252-270
6. Elsässer T., and Scholz M. Improvement of the local effect model (LEM) - implications of clustered DNA damage. Radiat. Prot. Dosim. (2006) 10.1093/rpd/ncl521
7. Fowler J., Chappell R., and Ritter M. Is alpha/beta for prostate tumors really low?. Int. J. Radiat. Oncol. Biol. Phys. 50 (2001) 1021-1031
8. Furusawa Y., Fukutsu K., Aoki M., Itsukaichi H., Eguchi-Kasai E., Ohara H., Yatagai F., Kanai T., and Ando K. Inactivation of aerobic and hypoxic cells from three different cell lines by accelerated 3He-, 12C- and 20Ne-ion beams. Radiat. Res. 154 (2000) 485-496
9. Goodhead D.T., Belli M., Mill A.J., et al. Direct comparison between protons and alpha-particles of the same LET: I. Irradiation methods and inactivation of asynchronous V79, HeLa and C3H10T1/2 cells. Int. J. Radiat. Biol. 61 (1992) 611-624
10. Gueulette J., Menzel H.G., Pihet P., and Wambersie A. Specification of radiation quality in fast neutron therapy: microdosimetric and radiobiological approach. Recent Results Cancer Res. 150 (1998) 31-53
11. Kagawa K., Murakami M., Hishikawa Y., Abe M., Akagi T., Yanou T., Kagiya G., Furusawa Y., Ando K., Nojima K., Aoki M., and Kanai T. Preclinical biological assessment of proton and carbon ion beams at Hyogo Ion Beam Medical Center. Int. J. Radiat. Oncol. Biol. Phys. 54 (2002) 928-938
12. Kal H.B., and van Gellekom M.P.R. How low is the alpha/beta ratio for prostate cancer?. Int. J. Radiat. Oncol. Biol. Phys. 57 (2003) 1116-1121
13. Kanai T., Furusawa Y., Fukutsu K., Itsukaichi H., Eguchi-Kasai K., and Ohara H. Irradiation of mixed beam and design of spread-out Bragg peak for heavy-ion radiotherapy. Radiat. Res. 147 (1997) 78-85
14. Kanai T., Endo M., Minohara S., Miyahara N., Koyama-ito H., Tomura H., Matsufuji N., Futami Y., Fukumura A., Hiraoka T., Furusawa Y., Ando K., Suzuki M., Soga F., and Kawachi K. Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 44 (1999) 201-210
15. Katz R., Ackerson B., Homayoonfar M., and Sharma S.C. Inactivation of cells by heavy ion bombardment. Radiat. Res. 47 (1971) 402-425
16. Kellerer A.M., and Rossi H.H. The theory of dual radiation action. Curr. Top. Radiat. Res. Q. 8 (1972) 85-158
17. In: Kiefer J. (Ed). Quantitative Mathematical Models in Radiation Biology (1988), Springer, Berlin 171-179
18. Kiefer J., and Straaten H. A model of ion track structure based on classical collision dynamics. Phys. Med. Biol. 31 (1986) 1201-1209
19. Kraft G. Radiobiological effects of very heavy ions: inactivation, induction of chromosome aberrations and strand breaks. Nucl. Sci. Appl. 3 (1987) 1-28
20. Krämer M., and Scholz M. Treatment planning for heavy-ion radio therapy: calculation and optimization of biologically effective dose. Phys. Med. Biol. 45 (2000) 3319-3330
21. Krämer M., Jäkel O., Haberer T., Kraft G., Schardt D., and Weber U. Treatment planning for heavy-ion radiotherapy: physical beam model and dose optimization. Phys. Med. Biol. 45 (2000) 3299-3317
22. Loncol T., Cosgrove V., Denis J.M., Gueulette J., Mazal A., Menzel H.G., Pihet P., and Sabattier R. Radiobiological effectiveness of radiation beams with broad LET spectra: microdosimetric analysis using biological weighting functions. Radiat. Prot. Dosim. 52 (1994) 347-352
23. Miller R.C., Geard C.R., Brenner D.J., Komatsu K., Marino S.A., and Hall E.J. Neutron-energy-dependent oncogenic transformation of C3H 10T1/2 mouse cells. Radiat. Res. 117 (1989) 114-127
24. Miller R.C., Marino S.A., Brenner D.J., Martin S.G., Richards M., Randers-Pehrson G., and Hall E.J. The biological effectiveness of radon-progeny alpha particles. II. Oncogenic transformation as a function of linear energy transfer. Radiat. Res. 142 (1995) 54-60
25. Ottolenghi A., Merzagora M., and Paretzke H.G. DNA complex lesions induced by protons and alpha-particles: track structure characteristics determining linear energy transfer and particle type dependence. Radiat. Environ. Biophys. 36 (1997) 97-103
26. Petti P.L., Lyman J.T., and Castro J.R. Sensitivity of helium beam-modulator design to uncertainties in biological data. Med. Phys. 18 (1991) 506-512
27. Petti P.L., Lyman J.T., Renner T.R., Castro J.R., Collier J.M., Daftari I.K., and Ludewigt B.A. Design of beam-modulating devices for charged particle therapy. Med. Phys. 18 (1991) 513-518
28. Pihet P., Menzel H.G., Schmidt R., Beauduin M., and Wambersie A. Biological weighting function for RBE specification of neutron therapy beams. Intercomparison of 9 european centres. Radiat. Prot. Dosim. 31 (1990) 437-442
29. Pohlit W., and Heyder I.R. The shape of dose-survival curves for mammalian cells and repair of potentially lethal damage analyzed by hypertonic treatment. Radiat. Res. 87 (1981) 613-634
30. Scholz M. Calculation of RBE for normal tissue complications based on charged particle track structure. Bull. Cancer Radiother. 83 Suppl. (1996) 50s-54s
31. Scholz M., and Kraft G. Calculation of heavy ion inactivation probabilities based on track structure, X-ray sensitivity and target size. Radiat. Prot. Dosim. 52 (1994) 29-33
32. Scholz M., and Kraft G. Track structure and the calculation of biological effects of heavy charged particles. Adv. Space Res. (1996) 5-14
33. Scholz M., and Kraft G. The physical and radiobiological basis of the local effect model: a response to the commentary by R. Katz. Rad. Res. 161 (2004) 612-620
34. Scholz M., Kellerer A.M., Kraft-Weyrather W., and Kraft G. Computation of cell survival in heavy ion beams for therapy - the model and its approximation. Radiat. Environ. Biophys. 36 (1997) 59-66
35. Slabbert J.P., Theron T., Zölzer F., Streffer C., and Böhm L. A comparison of the potential gain of p(66)/Be neutrons and d(14)/Be neutrons. Int. J. Radiat. Biol. Oncol. Phys. 47 (2000) 1059-1065
36. Spielberger B., Scholz M., Kramer M., and Kraft G. Calculation of the X-ray film response to heavy charged particle irradiation. Phys. Med. Biol. 47 (2002) 4107-4120
37. Tobias C.A., Blakely E.A., Ngo F.Q.H., and Yang T.C.H. The repair-misrepair model of cell survival. In: Meyn R.E., and Withers H.R. (Eds). Radiation Biology in Cancer Research (1980), Raven Press, New York 195-230
38. Tobias C.A., Blakely E.A., Chang P.Y., Lommel L., and Roots R. Response of sensitive human ataxia ans resistant T-1 cell lines to accelerated heavy ions. Br. J. Cancer 6 Suppl. (1984) 175-185
39. van der Schans G.P., Bleichrodt J.F., and Blok J. Contribution of various types of damage to inactivation of a biologically-active double-stranded circular DNA by gamma-radiation. Int. J. Radiat. Biol. 23 (1973) 133-150
40. Weyrather, W.K., Kraft, G. RBE of carbon ions: experimental data and the strategy of RBE calculation for treatment planning. Accepted for publication in Radiother. Oncol., 2003.
41. Weyrather W.K., Ritter S., Scholz M., and Kraft G. RBE for carbon track-segment irradiation in cell lines of different repair capacity. Int. J. Radiat. Biol. 75 (1999) 1357-1364
42. Zacharias T., Dörr W., Enghardt W., Haberer T., Krämer M., Kumpf R., Rothig H., Scholz M., Weber U., Kraft G., and Herrmann T. Acute response of pig skin to irradiation with 12C-ions or 200 kV X-rays. Acta Oncol. 36 (1997) 637-642
43. Zaider M., and Rossi H.H. The synergistic effects of different radiations. Radiat. Res. 83 (1980) 732-739