A comparative study of the plasma membrane permeabilization and fluidization induced by antipsychotic drugs in the rat brain

International Journal of Neuropsychopharmacology

Volumn 10, Issue 5, 2007, Pages 683-689

  Murata, Tetsuhito ^a   Maruoka, Nobuyuki ^a   Omata, Naoto ^a   Takashima, Yasuhiro ^a   Fujibayashi, Yasuhisa ^a   Yonekura, Yoshiharu ^a   Wada, Yuji ^a  

^a UNIVERSITY OF FUKUI   (Japan)

Author keywords

Chlorpromazine; Extrapyramidal side effects; Haloperidol; Plasma membrane; Sulpiride

Indexed keywords

1,6 DIPHENYL 1,3,5 HEXATRIENE; CHLORPROMAZINE; FLUORODEOXYGLUCOSE F 18; HALOPERIDOL; NEUROLEPTIC AGENT; SULPIRIDE;

ANIMAL CELL; ANIMAL TISSUE; ANISOTROPY; ARTICLE; BRAIN SLICE; CELL MEMBRANE; CONTROLLED STUDY; DRUG PENETRATION; EXTRAPYRAMIDAL SYMPTOM; MALE; MEMBRANE FLUIDITY; MEMBRANE PERMEABILITY; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; RAT; TARDIVE DYSKINESIA;

ANIMALS; ANISOTROPY; ANTIPSYCHOTIC AGENTS; AUTORADIOGRAPHY; BRAIN; BRAIN MAPPING; CELL MEMBRANE; CELL MEMBRANE PERMEABILITY; DIPHENYLHEXATRIENE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT DYES; FLUORODEOXYGLUCOSE F18; MALE; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; STATISTICS, NONPARAMETRIC;

EID: 34948865673     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145706007218     Document Type: Article

References (32)

1. 3H-adenine, and lactate dehydrogenase. Journal of Laboratory and Clinical Medicine 106, 253-261.
2. Baldessarini RJ, Centorrino F, Flood JG, Volpicelli SA, Huston-Lyons D, Cohen BM (1993). Tissue concentrations of clozapine and its metabolites in the rat. Neuropsychopharmacology 9, 117-124.
3. Boelsterli UA, Bouis P, Donatsch P (1987). Relative cytotoxicity of psychotropic drugs in cultured rat hepatocytes. Cell Biology and Toxicology 3, 231-250.
4. Brinkschulte M, Gaertner HJ, Schied HW, Breyer-Pfaff U (1982). Plasma protein binding of perazine and amitriptyline in psychiatric patients. European Journal of Clinical Pharmacology 22, 367-373.
5. Burkhardt C, Kelly JP, Lim YH, Filley CM, Parker Jr. WD (1993). Neuroleptic medications inhibit complex I of the electron transport chain. Annals of Neurology 33, 512-517.
6. Curry SH, Marshall JH, Davis JM, Janowsky DS (1970). Chlorpromazine plasma levels and effects. Archives of General Psychiatry 22, 289-296.
7. Dwyer DS, Lu XH, Bradley RJ (2003). Cytotoxicity of conventional and atypical antipsychotic drugs in relation to glucose metabolism. Brain Research 971, 31-39.
8. Gerlach J, Casey DE (1984). Sulpiride in tardive dyskinesia. Acta Psychiatrica Scandinavica Supplementum 311, 93-102.
9. Gerlach J, Casey DE (1988). Tardive dyskinesia. Acta Psychiatrica Scandinavica 77, 369-378.
10. 3H]dopamine release and their lipophilicity. Biochemical Pharmacology 32, 2411-2416.
11. Gray EG, Whittaker VP (1962). The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation. Journal of Anatomy 96, 79-88.
12. Gunne LM, Andersson U, Bondesson U, Johansson P (1986). Spontaneous chewing movements in rats during acute and chronic antipsychotic drug administration. Pharmacology Biochemistry and Behavior 25, 897-901.
13. 18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. Journal of Nuclear Medicine 27, 235-238.
14. Katsu T, Kobayashi H, Hirota T, Fujita Y, Sato K, Nagai U (1987). Structure-activity relationship of gramicidin S analogues on membrane permeability. Biochimica et Biophysica Acta 899, 159-170.
15. Kornhuber J, Schultz A, Wiltfang J, Meineke I, Gleiter CH, Zochling R, Boissl KW, Leblhuber F, Riederer P (1999). Persistence of haloperidol in human brain tissue. American Journal of Psychiatry 156, 885-890.
16. Marsden CD, Jenner P (1980). The pathophysiology of extrapyramidal side-effects of neuroleptic drugs. Psychological Medicine 10, 55-72.
17. Meltzer HY, Cola PA, Parsa M (1996). Marked elevations of serum creatine kinase activity associated with antipsychotic drug treatment. Neuropsychopharmacology 15, 395-405.
18. Murata T, Omata N, Fujibayashi Y, Waki A, Sadato N, Yoshida S, Yano R, Yoshimoto M, Yonekura Y (1999). Dynamic changes in glucose metabolism of living rat brain slices induced by hypoxia and neurotoxic chemical-loading revealed by positron autoradiography. Journal of Neural Transmission 106, 1075-1087.
19. Ohyashiki T, Sakata N, Matsui K (1992). A decrease of lipid fluidity of the porcine intestinal brush-border membranes by treatment with malondialdehyde. Journal of Biochemistry 111, 419-423.
20. Omata N, Murata T, Fujibayashi Y, Waki A, Sadato N, Yoshimoto M, Wada Y, Yonekura Y (2000). Hypoxic but not ischemic neurotoxicity of free radicals revealed by dynamic changes in glucose metabolism of fresh rat brain slices on positron autoradiography. Journal of Cerebral Blood Flow and Metabolism 20, 350-358.
21. Pappu AS, Hauser G (1981). Alterations of phospholipid metabolism in rat cerebral cortex mince induced by cationic amphiphilic drugs. Journal of Neurochemistry 37, 1006-1014.
22. Paxinos G, Watson C (1998). The Rat Brain in Stereotaxic Coordinates (4th edn). San Diego: Academic Press.
23. Rissanen E, Krumschnabel G, Nikinmaa M (2003). Dehydroabietic acid, a major component of wood industry effluents, interferes with cellular energetics in rainbow trout hepatocytes. Aquatic Toxicology 62, 45-53.
24. Seeman P (1977). Anti-schizophrenic drug - membrane receptor sites of action. Biochemical Pharmacology 26, 1741-1748.
25. Seeman P, Staiman A, Lee T, Chau-Wong M (1974). The membrane actions of tranquilizers in relation to neuroleptic-induced parkinsonism and tardive dyskinesia. Advances in Biochemical Psychopharmacology 9, 137-148.
26. Shinitzky M, Barenholz Y (1978). Fluidity parameters of lipid regions determined by fluorescence polarization. Biochimica et Biophysica Acta 515, 367-394.
27. Shinitzky M, Inbar M (1976). Microviscosity parameters and protein mobility in biological membranes. Biochimica et Biophysica Acta 433, 133-149.
28. Spila-Alegiani S, Diana G, Menniti-Ippolito F, Raschetti R (1995). Anticholinergic antiparkinsonian therapy in outpatients treated with neuroleptic drugs: a prescription survey. European Journal of Clinical Pharmacology 48, 513-517.
29. Tharmapathy P, Fukami MH, Holmsen H (2000). The stimulatory effects of cationic amphiphilic drugs on human platelets treated with thrombin. Biochemical Pharmacology 60, 1267-1277.
30. Ulrich S, Wurthmann C, Brosz M, Meyer FP (1998). The relationship between serum concentration and therapeutic effect of haloperidol in patients with acute schizophrenia. Clinical Pharmacokinetics 34, 227-263.
31. Volles MJ, Lee SJ, Rochet JC, Shtilerman MD, Ding TT, Kessler JC, Lansbury Jr. PT (2001). Vesicle permeabilization by protofibrillar a-synuclein: implications for the pathogenesis and treatment of Parkinson's disease. Biochemistry 40, 7812-7819.
32. Walum E, Peterson A (1982). Tritiated 2-deoxy-D-glucose as a probe for cell membrane permeability studies. Analytical Biochemistry 120, 8-11.