A potential trigger of nephritogenic anti-DNA antibodies in lupus nephritis

Annals of the New York Academy of Sciences

Volumn 1108, Issue , 2007, Pages 92-95

  Hirabayashi, Yasuhiko ^a   Oka, Y ^a   Tada, M ^a   Takahashi, R ^a   Ishii, T ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Anti DNA antibody; Cell stress; Lupus nephritis; Molecular mimicry; Systemic lupus erythematosus

Indexed keywords

AUTOANTIBODY; DNA ANTIBODY; DOUBLE STRANDED DNA ANTIBODY; GENE PRODUCT; HERP PROTEIN; IMMUNOGLOBULIN G; NEPHRITOGENIC ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIGENICITY; BAGG ALBINO MOUSE; CELL STRESS; CLONING; CONFERENCE PAPER; CONTROLLED STUDY; DNA BINDING; DNA LIBRARY; DRUG SYNTHESIS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ESCHERICHIA COLI; FEMALE; GLOMERULUS; IMMUNIZATION; LUPUS ERYTHEMATOSUS NEPHRITIS; MOUSE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PURIFICATION; RISK FACTOR; ULTRAVIOLET RADIATION; VIRUS INFECTION;

ESCHERICHIA COLI; MAMMALIA; MUS;

EID: 34948860054     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1422.010     Document Type: Conference Paper

References (17)

1. HAHN, B.H. 1998. Antibodies to DNA. N. Engl. J. Med. 338: 1359-1368.
2. MADAIO, M.P. et al. 1984. Responsiveness of autoimmune and normal mice to nucleic acid antigens. J. Immunol. 132: 872-876.
3. DESAI, D.D. et al. 1993. Antigen-specific induction of antibodies against native mammalian DNA in nonautoimmune mice. J. Immunol. 151: 1614-1626.
4. REKVIG, O.P. et al. 1997. Human polyomavirus BK and immunogenicity of mammalian DNA: a conceptual framework. Methods 11: 44-54.
5. MARCHINI, B. et al. 1995. Induction of anti-DNA antibodies in non autoimmune mice by immunization with a DNA-DNAase I complex. Clin. Exp. Rheumatol. 13: 7-10.
6. VOYNOVA, E.N. et al. 2005. Breaking of tolerance to native DNA in nonautoimmune mice by immunization with natural protein/DNA complexes. Lupus 14: 543-550.
7. VIARD, J.P. et al. 1987. Splenocytes from MRL/Mp-lpr/lpr mice spontaneously produce antibodies against a cell-surface protein cross-reacting with DNA. Clin. Immunol. Immunopathol. 45: 516-521.
8. ZACK, D.J. et al. 1995. DNA mimics a self-protein that may be a target for some anti-DNA antibodies in systemic lupus erythematosus. J. Immunol. 154: 1987-1994.
9. YANASE, K. et al. 1997. Receptor-mediated cellular entry of nuclear localizing anti-DNA antibodies via myosin 1. J. Clin. Invest. 100: 25-31.
10. SEDDIKI, N. et al. 2001. Calreticulin, a potential cell surface receptor involved in cell penetration of anti-DNA antibodies. J. Immunol. 166: 6423-6429.
11. DEGIORGIO, L.A. et al. 2001. A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat. Med. 7: 1189-1193.
12. MOSTOSLAVSKY, G. et al. 2001. Lupus anti-DNA autoantibodies cross-react with a glomerular structural protein: a case for tissue injury by molecular mimicry. Eur. J. Immunol. 31: 1221-1227.
13. MASON, L.J. et al. 2004. Is alpha-actinin a target for pathogenic anti-DNA antibodies in lupus nephritis? Arthritis Rheum. 50: 866-870.
14. DEOCHARAN, B. et al. 2002. Alpha-actinin is a cross-reactive renal target for pathogenic anti-DNA antibodies. J. Immunol. 168: 3072-3078.
15. PUTTERMAN, C. et al. 1998. Immunization with a peptide surrogate for double-stranded DNA (dsDNA) induces autoantibody production and renal immunoglobulin deposition. J. Exp. Med. 188: 29-38.
16. MURYOI, T. et al. 1990. Clonotypes of anti-DNA antibodies expressing specific idiotypes in immune complexes of patients with active lupus nephritis. J. Immunol. 144: 3856-3861.
17. HIRABAYASHI, Y. et al. 1992. Variable regions of a human anti-DNA antibody O-81 possessing lupus nephritis-associated idiotype. Nucleic Acids Res. 20: 2601.