Identification of a common subnuclear localization signal

Molecular Biology of the Cell

Volumn 18, Issue 10, 2007, Pages 3966-3977

  Mekhail, Karim ^a,b   Rivero Lopez, Luis ^a   Al Masri, Ahmad ^a   Brandon, Caroline ^a   Khacho, Mireille ^a   Lee, Stephen ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; HEAT SHOCK COGNATE PROTEIN 70; REGULATOR PROTEIN; VON HIPPEL LINDAU PROTEIN;

ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; HUMAN CELL; NUCLEAR LOCALIZATION SIGNAL; NUCLEOLUS; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ACIDOSIS; AMINO ACID SEQUENCE; CELL LINE, TUMOR; CELL NUCLEOLUS; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; MUTAGENESIS; NUCLEAR LOCALIZATION SIGNALS; REPRODUCIBILITY OF RESULTS; VON HIPPEL-LINDAU TUMOR SUPPRESSOR PROTEIN;

EID: 34948859424     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E07-03-0295     Document Type: Article

References (62)

1. Andersen, J. S., Lam, Y. W., Leung, A. K., Ong, S. E., Lyon, C. E., Lamond, A. I., and Mann, M. (2005). Nucleolar proteome dynamics. Nature 433, 77-83.
2. Andersen, J. S., Lyon, C. E., Fox, A. H., Leung, A. K., Lam, Y. W., Steen, H., Mann, M., and Lamond, A. I. (2002). Directed proteomic analysis of the human nucleolus. Curr. Biol. 12, 1-11.
3. Azzam, R., Chen, S. L., Shou, W., Mah, A. S., Alexandru, G., Nasmyth, K., Annan, R. S., Carr, S. A., and Deshaies, R. J. (2004). Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. Science 305, 516-519.
4. Bairoch, A., Boeckmann, B., Ferro, S., and Gasteiger, E. (2004). Swiss-Prot: juggling between evolution and stability. Brief Bioinform. 5, 39-55.
5. Barseguian, K., Lutterbach, B., Hiebert, S. W., Nickerson, J., Lian, J. B., Stein, J. L., van Wijnen, A. J., and Stein, G. S. (2002). Multiple subnuclear targeting signals of the leukemia-related AML1/ETO and ETO repressor proteins. Proc. Natl. Acad. Sci. USA 99, 15434-15439.
6. Bonicalzi, M. E., Groulx, I., de Paulsen, N., and Lee, S. (2001). Role of exon 2-encoded beta -domain of the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 276, 1407-1416.
7. Bukau, B., and Horwich, A. L. (1998). The Hsp70 and Hsp60 chaperone machines. Cell 92, 351-366.
8. Caceres, J. F., Misteli, T., Screaton, G. R., Spector, D. L., and Krainer, A. R. (1997). Role of the modular domains of SR proteins in subnuclear localization and alternative splicing specificity. J. Cell Biol. 138, 225-238.
9. Catez, F., Erard, M., Schaerer-Uthurralt, N., Kindbeiter, K., Madjar, J. J., and Diaz, J. J. (2002). Unique motif for nucleolar retention and nuclear export regulated by phosphorylation. Mol. Cell. Biol. 22, 1126-1139.
10. Chatterjee, T. K., and Fisher, R. A. (2002). RGS12TS-S localizes at nuclear matrix-associated subnuclear structures and represses transcription: structural requirements for subnuclear targeting and transcriptional repression. Mol. Cell. Biol. 22, 4334-4345.
11. Chubb, J. R., and Bickmore, W. A. (2003). Considering nuclear compartmentalization in the light of nuclear dynamics. Cell 112, 403-406.
12. Conti, E., and Izaurralde, E. (2001). Nucleocytoplasmic transport enters the atomic age. Curr. Opin. Cell Biol. 13, 310-319.
13. Dundr, M., Hebert, M. D., Karpova, T. S., Stanek, D., Xu, H., Shpargel, K. B., Meier, U. T., Neugebauer, K. M., Matera, A. G., and Misteli, T. (2004). In vivo kinetics of Cajal body components. J. Cell Biol. 164, 831-842.
14. Dundr, M., Misteli, T., and Olson, M. O. (2000). The dynamics of postmitotic reassembly of the nucleolus. J. Cell Biol. 150, 433-446.
15. Easton, D. P., Kaneko, Y., and Subjeck, J. R. (2000). The hsp110 and Grp1 70 stress proteins: newly recognized relatives of the Hsp70s. Cell Stress Chaperones 5, 276-290.
16. Groulx, I., and Lee, S. (2002). Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein. Mol. Cell. Biol. 22, 5319
17. Hebert, M. D., and Matera, A. G. (2000). Self-association of coilin reveals a common theme in nuclear body localization. Mol. Biol. Cell 11, 4159-4171.
18. Hiscox, J. A. (2002). The nucleolus - a gateway to viral infection? Arch. Virol. 147, 1077-1089.
19. Iliopoulos, O., Kibel, A., Gray, S., and Kaelin, W. G., Jr. (1995). Tumour suppression by the human von Hippel-Lindau gene product. Nat. Med. 1, 822-826.
20. Ishikawa, H., Kato, M., Hori, H., Ishimori, K., Kirisako, T., Tokunaga, F., and Iwai, K. (2005). Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2. Mol. Cell 19, 171-181.
21. Isogai, Y., and Tjian, R. (2003). Targeting genes and transcription factors to segregated nuclear compartments. Curr. Opin. Cell Biol. 15, 296-303.
22. Kosak, S. T., and Groudine, M. (2004). Form follows function: the genomic organization of cellular differentiation. Genes Dev. 18, 1371-1384.
23. Kutay, U., and Guttinger, S. (2005). Leucine-rich nuclear-export signals: born to be weak. Trends Cell Biol. 15, 121-124.
24. Lam, Y. W., Trinkle-Mulcahy, L., and Lamond, A. I. (2005). The nucleolus. J. Cell Sci. 118, 1335-1337.
25. Lee, B. J., Cansizoglu, A. E., Suel, K. E., Louis, T. H., Zhang, Z., and Chook, Y. M. (2006). Rules for nuclear localization sequence recognition by karyopherin beta 2. Cell 126, 543-558.
26. 2 by metal-catalysed histidine oxidation. Nature 440, 363-367.
27. Leung, A. K., Gerlich, D., Miller, G., Lyon, C., Lam, Y. W., Lleres, D., Daigle, N., Zomerdijk, J., Ellenberg, J., and Lamond, A. I. (2004). Quantitative kinetic analysis of nucleolar breakdown and reassembly during mitosis in live human cells. J. Cell Biol. 166, 787-800.
28. Linding, R., Jensen, L. J., Diella, F., Bork, P., Gibson, T. J., and Russell, R. B. (2003). Protein disorder prediction: implications for structural proteomics. Structure 11, 1453-1459.
29. Lippincott-Schwartz, J., Altan-Bonnet, N., and Patterson, G. H. (2003). Photobleaching and photoactivation: following protein dynamics in living cells. Nat. Cell Biol. Suppl. S7-S14.
30. Lohrum, M. A., Ashcroft, M., Kubbutat, M. H., and Vousden, K. H. (2000). Identification of a cryptic nucleolar-localization signal in MDM2. Nat. Cell Biol. 2, 179-181.
31. Lohrum, M. A., Ludwig, R. L., Kubbutat, M. H., Hanlon, M., and Vousden, K. H. (2003). Regulation of HDM2 activity by the ribosomal protein L11. Cancer Cell 3, 577-587.
32. Ludwig, M. G., Vanek, M., Guerini, D., Gasser, J. A., Jones, C. E., Junker, U., Hofstetter, H., Wolf, R. M., and Seuwen, K. (2003). Proton-sensing G-protein-coupled receptors. Nature 425, 93-98.
33. Mekhail, K., Gunaratnam, L., Bonicalzi, M. E., and Lee, S. (2004a). HIF activation by pH-dependent nucleolar sequestration of VHL. Nat. Cell Biol. 6, 642-647.
34. Mekhail, K., Khacho, M., Carrigan, A., Hache, R. R., Gunaratnam, L., and Lee, S. (2005). Regulation of ubiquitin ligase dynamics by the nucleolus. J. Cell Biol. 170, 733-744.
35. +: implications for HIF and hypoxic cell memory. Cell Cycle 3, 1027-1029.
36. Mekhail, K., Rivero-Lopez, L., Khacho, M., and Lee, S. (2006). Restriction of rRNA synthesis by VHL maintains energy equilibrium under hypoxia. Cell Cycle 5, 2401-2413.
37. Misteli, T. (2001). Protein dynamics: implications for nuclear architecture and gene expression. Science 291, 843-847.
38. Misteli, T. (2004). Spatial positioning; a new dimension in genome function. Cell 119, 153-156.
39. Murakami, N., Yokomizo, T., Okuno, T., and Shimizu, T. (2004). G2A is a proton-sensing G-protein-coupled receptor antagonized by lysophosphatidylcholine. J. Biol. Chem. 279, 42484-42491.
40. Paushkin, S. V., Patel, M., Furia, B. S., Peltz, S. W., and Trotta, C. R. (2004). Identification of a human endonuclease complex reveals a link between tRNA splicing and pre-mRNA 3′ end formation. Cell 117, 311-321.
41. Pelham, H. R. (1984). Hsp70 accelerates the recovery of nucleolar morphology after heat shock. EMBO J. 3, 3095-3100.
42. Phair, R. D., and Misteli, T. (2000). High mobility of proteins in the mammalian cell nucleus. Nature 404, 604
43. Ramsey, I. S., Moran, M. M., Chong, J. A., and Clapham, D. E. (2006). A voltage-gated proton-selective channel lacking the pore domain. Nature 440, 1213-1216.
44. Reed, M. L., Dove, B. K., Jackson, R. M., Collins, R., Brooks, G., and Hiscox, J. A. (2006). Delineation and modelling of a nucleolar retention signal in the Coronavirus nucleocapsid protein. Traffic 7, 833-848.
45. Shaw, P., and Doonan, J. (2005). The nucleolus. Playing by different rules? Cell Cycle 4, 102-105.
46. Shikano, S., Coblitz, B., Sun, H., and Li, M. (2005). Genetic isolation of transport signals directing cell surface expression. Nat. Cell Biol. 7, 985-992.
47. Shou, W. et al. (2001). Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit. Mol. Cell 8, 45-55.
48. Shou, W., Seol, J. H., Shevchenko, A., Baskerville, C., Moazed, D., Chen, Z. W., Jang, J., Charbonneau, H., and Deshaies, R. J. (1999). Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97, 233-244.
49. Song, Z., and Wu, M. (2005). Identification of a novel nucleolar localization signal and a degradation signal in Survivin-deltaEx3, a potential link between nucleolus and protein degradation. Oncogene 24, 2723-2734.
50. Stewart, A. K., Kerr, N., Chernova, M. N., Alper, S. L., and Vaughan-Jones, R. D. (2004). Acute pH-dependent regulation of AE2-mediated anion exchange involves discrete local surfaces of the NH2-terminal cytoplasmic domain. J. Biol. Chem. 279, 52664-52676.
51. Takano, Y. et al. (2004). The RING finger protein, RNF8, interacts with retinoid X receptor alpha and enhances its transcription-stimulating activity. J. Biol. Chem. 279, 18926-18934.
52. Tao, W., and Levine, A. J. (1999). P19(ARF) stabilizes p53 by blocking nucleocytoplasmic shuttling of Mdm2. Proc. Natl. Acad. Sci. USA 96, 6937-6941.
53. Tong, C., Tan, L., Li, P., and Zhu, Y. S. (2005). Identification of a novel nucleus protein involved in the regulation of urokinase in 95D cells. Acta Biochim. Biophys. Sin. 37, 303-309.
54. Tsai, R. Y., and McKay, R. D. (2005). A multistep, GTP-driven mechanism controlling the dynamic cycling of nucleostemin. J. Cell Biol. 168, 179-184.
55. van den Boom, V., Citterio, E., Hoogstraten, D., Zotter, A., Egly, J. M., van Cappellen, W. A., Hoeijmakers, J. H., Houtsmuller, A. B., and Vermeulen, W. (2004). DNA damage stabilizes interaction of CSB with the transcription elongation machinery. J. Cell Biol. 166, 27-36.
56. Visintin, R., Hwang, E. S., and Amon, A. (1999). Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus. Nature 398, 818-823.
57. Weber, J. D., Kuo, M. L., Bothner, B., DiGiammarino, E. L., Kriwacki, R. W., Roussel, M. F., and Sherr, C. J. (2000). Cooperative signals governing ARF-mdm2 interaction and nucleolar localization of the complex. Mol. Cell. Biol. 20, 2517-2528.
58. Weber, J. D., Taylor, L. J., Roussel, M. F., Sherr, C. J., and Bar-Sagi, D. (1999). Nucleolar Arf sequesters Mdm2 and activates p53. Nat. Cell Biol. 1, 20-26.
59. Wong, J. M., Kusdra, L., and Collins, K. (2002). Subnuclear shuttling of human telomerase induced by transformation and DNA damage. Nat. Cell Biol. 4, 731-736.
60. Zaidi, S. K., Young, D. W., Choi, J. Y., Pratap, J., Javed, A., Montecino, M., Stein, J. L., van Wijnen, A. J., Lian, J. B., and Stein, G. S. (2005). The dynamic organization of gene-regulatory machinery in nuclear microenvironments. EMBO Rep. 6, 128-133.
61. Zeng, C., van Wijnen, A. J., Stein, J. L., Meyers, S., Sun, W., Shopland, L., Lawrence, J. B., Penman, S., Lian, J. B., Stein, G. S., and Hiebert, S. W. (1997). Identification of a nuclear matrix targeting signal in the leukemia and bone-related AML/CBF-alpha transcription factors. Proc. Natl. Acad. Sci. USA 94, 6746-6751.
62. Zimber, A., Nguyen, Q. D., and Gespach, C. (2004). Nuclear bodies and compartments: functional roles and cellular signalling in health and disease. Cell Signal 16, 1085-1104.