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Volumn 19, Issue 6, 2007, Pages 598-603

Screening and therapy of pulmonary hypertension in systemic sclerosis

Author keywords

Pulmonary hypertension; Scleroderma; Screening; Vasodilator

Indexed keywords

AMBRISENTAN; BIOLOGICAL MARKER; BOSENTAN; ENDOTHELIN RECEPTOR ANTAGONIST; ILOPROST; IMATINIB; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; PROSTACYCLIN; SILDENAFIL; SITAXSENTAN; UNIPROST;

EID: 34948853740     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/BOR.0b013e3282ec67d4     Document Type: Review
Times cited : (17)

References (45)
  • 1
    • 13544274462 scopus 로고    scopus 로고
    • The lung in systemic sclerosis
    • Steen VD. The lung in systemic sclerosis. J Clin Rheumatol 2005; 11:40-46.
    • (2005) J Clin Rheumatol , vol.11 , pp. 40-46
    • Steen, V.D.1
  • 2
    • 0142187600 scopus 로고    scopus 로고
    • Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: Application of a registry approach
    • Mukerjee D, St George D, Coleiro B, et al. Prevalence and outcome in systemic sclerosis associated pulmonary arterial hypertension: application of a registry approach. Ann Rheum Dis 2003; 62:1088-1093.
    • (2003) Ann Rheum Dis , vol.62 , pp. 1088-1093
    • Mukerjee, D.1    St George, D.2    Coleiro, B.3
  • 3
    • 0037331116 scopus 로고    scopus 로고
    • Hemodynamics and survival in patients with pulmonary arterial hypertension related to systemic sclerosis
    • Kawut SM, Taichman DB, Archer-Chicko CL, et al. Hemodynamics and survival in patients with pulmonary arterial hypertension related to systemic sclerosis. Chest 2003; 123:344-350.
    • (2003) Chest , vol.123 , pp. 344-350
    • Kawut, S.M.1    Taichman, D.B.2    Archer-Chicko, C.L.3
  • 4
    • 33749329543 scopus 로고    scopus 로고
    • Clinical differences between idiopathic and scleroderma-related pulmonary hypertension
    • Fisher MR, Mathai SC, Champion HC, et al. Clinical differences between idiopathic and scleroderma-related pulmonary hypertension. Arthritis Rheum 2006; 54:3043-3050.
    • (2006) Arthritis Rheum , vol.54 , pp. 3043-3050
    • Fisher, M.R.1    Mathai, S.C.2    Champion, H.C.3
  • 5
    • 10044258461 scopus 로고    scopus 로고
    • Guidelines on diagnosis and treatment of pulmonary arterial hypertension. The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology
    • Galie N, Torbicki A, Barst R, et al. Guidelines on diagnosis and treatment of pulmonary arterial hypertension. The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology. Eur Heart J 2004; 25:2243-2278.
    • (2004) Eur Heart J , vol.25 , pp. 2243-2278
    • Galie, N.1    Torbicki, A.2    Barst, R.3
  • 6
    • 34347266509 scopus 로고    scopus 로고
    • Changes in causes of death in systemic sclerosis
    • This paper is a longitudinal evaluation of the cause of death from SSc from a single center University of Pittsburgh, It is the longest evaluation of its kind, providing information on patient outcome as new treatment strategies have been adopted
    • Steen VD, Medsger TA Jr. Changes in causes of death in systemic sclerosis. Ann Rheum Dis 2007; 66:940-944. This paper is a longitudinal evaluation of the cause of death from SSc from a single center (University of Pittsburgh). It is the longest evaluation of its kind, providing information on patient outcome as new treatment strategies have been adopted.
    • (2007) Ann Rheum Dis , vol.66 , pp. 940-944
    • Steen, V.D.1    Medsger Jr., T.A.2
  • 7
    • 3142692425 scopus 로고    scopus 로고
    • Screening, early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines
    • McGoon M, Gutterman D, Steen V, et al. Screening, early detection, and diagnosis of pulmonary arterial hypertension: ACCP evidence-based clinical practice guidelines. Chest 2004; 126:14S-34S.
    • (2004) Chest , vol.126
    • McGoon, M.1    Gutterman, D.2    Steen, V.3
  • 8
    • 0023615359 scopus 로고
    • Primary pulmonary hypertension: A national prospective study
    • Rich S, Dantzker DR, Ayres SM, et al. Primary pulmonary hypertension: a national prospective study. Ann Intern Med 1987; 107:216-223.
    • (1987) Ann Intern Med , vol.107 , pp. 216-223
    • Rich, S.1    Dantzker, D.R.2    Ayres, S.M.3
  • 9
    • 0030463427 scopus 로고    scopus 로고
    • Prevalence of pulmonary hypertension in limited and diffuse scleroderma
    • Battle RW, Davitt MA, Cooper SM, et al. Prevalence of pulmonary hypertension in limited and diffuse scleroderma. Chest 1996; 110:1515-1519.
    • (1996) Chest , vol.110 , pp. 1515-1519
    • Battle, R.W.1    Davitt, M.A.2    Cooper, S.M.3
  • 10
    • 0030841153 scopus 로고    scopus 로고
    • Comparison of Doppler echocardiography and right heart catheterization to assess pulmonary hypertension in systemic sclerosis
    • Denton CP, Cailes JB, Phillips GD, et al. Comparison of Doppler echocardiography and right heart catheterization to assess pulmonary hypertension in systemic sclerosis. Br J Rheumatol 1997; 36:239-243.
    • (1997) Br J Rheumatol , vol.36 , pp. 239-243
    • Denton, C.P.1    Cailes, J.B.2    Phillips, G.D.3
  • 11
    • 1842866218 scopus 로고    scopus 로고
    • Echocardiography and pulmonary function as screening tests for pulmonary arterial hypertension in systemic sclerosis
    • Mukerjee D, St George D, Knight C, et al. Echocardiography and pulmonary function as screening tests for pulmonary arterial hypertension in systemic sclerosis. Rheumatology (Oxford) 2004; 43:461-466.
    • (2004) Rheumatology (Oxford) , vol.43 , pp. 461-466
    • Mukerjee, D.1    St George, D.2    Knight, C.3
  • 12
    • 0034609543 scopus 로고    scopus 로고
    • Abnormal pulmonary artery pressure response in asymptomatic carriers of primary pulmonary hypertension gene
    • Grunig E, Janssen B, Mereles D, et al. Abnormal pulmonary artery pressure response in asymptomatic carriers of primary pulmonary hypertension gene. Circulation 2000; 102:1145-1150.
    • (2000) Circulation , vol.102 , pp. 1145-1150
    • Grunig, E.1    Janssen, B.2    Mereles, D.3
  • 13
    • 33750031478 scopus 로고    scopus 로고
    • Abnormal pulmonary vascular responses in patients registered with a systemic autoimmunity database: Pulmonary Hypertension Assessment and Screening Evaluation using stress echocardiography (PHASE-I)
    • Collins N, Bastian B, Quiqueree L, et al. Abnormal pulmonary vascular responses in patients registered with a systemic autoimmunity database: Pulmonary Hypertension Assessment and Screening Evaluation using stress echocardiography (PHASE-I). Eur J Echocardiogr 2006; 7:439-446.
    • (2006) Eur J Echocardiogr , vol.7 , pp. 439-446
    • Collins, N.1    Bastian, B.2    Quiqueree, L.3
  • 14
    • 33746359362 scopus 로고    scopus 로고
    • Reduced exercise capacity and stress-induced pulmonary hypertension in patients with scleroderma
    • Alkotob ML, Soltani P, Sheatt MA, et al. Reduced exercise capacity and stress-induced pulmonary hypertension in patients with scleroderma. Chest 2006; 130:176-181.
    • (2006) Chest , vol.130 , pp. 176-181
    • Alkotob, M.L.1    Soltani, P.2    Sheatt, M.A.3
  • 15
    • 0037331671 scopus 로고    scopus 로고
    • Predictors of isolated pulmonary hypertension in patients with systemic sclerosis and limited cutaneous involvement
    • Steen V, Medsger TA Jr. Predictors of isolated pulmonary hypertension in patients with systemic sclerosis and limited cutaneous involvement. Arthritis Rheum 2003; 48:516-522.
    • (2003) Arthritis Rheum , vol.48 , pp. 516-522
    • Steen, V.1    Medsger Jr., T.A.2
  • 16
    • 0023867456 scopus 로고
    • A new natriuretic peptide in porcine brain
    • Sudoh T, Kangawa K, Minamino N, Matsuo H. A new natriuretic peptide in porcine brain. Nature 1988; 332:78-81.
    • (1988) Nature , vol.332 , pp. 78-81
    • Sudoh, T.1    Kangawa, K.2    Minamino, N.3    Matsuo, H.4
  • 17
    • 0025729993 scopus 로고
    • Brain natriuretic peptide as a novel cardiac hormone in humans: Evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide
    • Mukoyama M, Nakao K, Hosoda K, et al. Brain natriuretic peptide as a novel cardiac hormone in humans: evidence for an exquisite dual natriuretic peptide system, atrial natriuretic peptide and brain natriuretic peptide. J Clin Invest 1991; 87:1402-1412.
    • (1991) J Clin Invest , vol.87 , pp. 1402-1412
    • Mukoyama, M.1    Nakao, K.2    Hosoda, K.3
  • 18
    • 33644876940 scopus 로고    scopus 로고
    • NT-ProBNP in acute heart failure: Correlation with invasively measured hemodynamic parameters during recompensation
    • Knebel F, Schimke I, Pliet K, et al. NT-ProBNP in acute heart failure: correlation with invasively measured hemodynamic parameters during recompensation. J Card Fail 2005; 11:S38-S41.
    • (2005) J Card Fail , vol.11
    • Knebel, F.1    Schimke, I.2    Pliet, K.3
  • 19
    • 0029948712 scopus 로고    scopus 로고
    • Plasma brain natriuretic peptide as an indicator of left ventricular systolic function and long-term survival after acute myocardial infarction: Comparison with plasma atrial natriuretic peptide and N-terminal proatrial natriuretic peptide
    • Omland T, Aakvaag A, Bonarjee VV, et al. Plasma brain natriuretic peptide as an indicator of left ventricular systolic function and long-term survival after acute myocardial infarction: comparison with plasma atrial natriuretic peptide and N-terminal proatrial natriuretic peptide. Circulation 1996; 93:1963-1969.
    • (1996) Circulation , vol.93 , pp. 1963-1969
    • Omland, T.1    Aakvaag, A.2    Bonarjee, V.V.3
  • 20
    • 0034702908 scopus 로고    scopus 로고
    • Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension
    • Nagaya N, Nishikimi T, Uematsu M, et al. Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension. Circulation 2000; 102:865-870.
    • (2000) Circulation , vol.102 , pp. 865-870
    • Nagaya, N.1    Nishikimi, T.2    Uematsu, M.3
  • 21
    • 17144452791 scopus 로고    scopus 로고
    • Plasma brain natriuretic peptide levels increase in proportion to the extent of right ventricular dysfunction in pulmonary hypertension
    • Nagaya N, Nishikimi T, Okano Y, et al. Plasma brain natriuretic peptide levels increase in proportion to the extent of right ventricular dysfunction in pulmonary hypertension. J Am Coll Cardiol 1998; 31:202-208.
    • (1998) J Am Coll Cardiol , vol.31 , pp. 202-208
    • Nagaya, N.1    Nishikimi, T.2    Okano, Y.3
  • 22
    • 33745725935 scopus 로고    scopus 로고
    • Role of N-terminal brain natriuretic peptide (N-TproBNP) in scleroderma-associated pulmonary arterial hypertension
    • A direct application of a serum biomarker for diagnosis and prognosis of PAH in SSc
    • Williams MH, Handler CE, Akram R, et al. Role of N-terminal brain natriuretic peptide (N-TproBNP) in scleroderma-associated pulmonary arterial hypertension. Eur Heart J 2006; 27:1485-1494. A direct application of a serum biomarker for diagnosis and prognosis of PAH in SSc.
    • (2006) Eur Heart J , vol.27 , pp. 1485-1494
    • Williams, M.H.1    Handler, C.E.2    Akram, R.3
  • 23
    • 0026537043 scopus 로고
    • Autoantibody to U3 nucleolar ribonucleoprotein (fibrillarin) in patients with systemic sclerosis
    • Okano Y, Steen VD, Medsger TA Jr. Autoantibody to U3 nucleolar ribonucleoprotein (fibrillarin) in patients with systemic sclerosis. Arthritis Rheum 1992; 35:95-100.
    • (1992) Arthritis Rheum , vol.35 , pp. 95-100
    • Okano, Y.1    Steen, V.D.2    Medsger Jr., T.A.3
  • 24
    • 0037231639 scopus 로고    scopus 로고
    • A comparison between anti-Th/To- and anticentromere antibody-positive systemic sclerosis patients with limited cutaneous involvement
    • Mitri GM, Lucas M, Fertig N, et al. A comparison between anti-Th/To- and anticentromere antibody-positive systemic sclerosis patients with limited cutaneous involvement. Arthritis Rheum 2003; 48:203-209.
    • (2003) Arthritis Rheum , vol.48 , pp. 203-209
    • Mitri, G.M.1    Lucas, M.2    Fertig, N.3
  • 25
    • 0037440854 scopus 로고    scopus 로고
    • Autoantibodies against B23, a nucleolar phosphoprotein, occur in scleroderma and are associated with pulmonary hypertension
    • Ulanet DB, Wigley FM, Gelber AC, Rosen A. Autoantibodies against B23, a nucleolar phosphoprotein, occur in scleroderma and are associated with pulmonary hypertension. Arthritis Rheum 2003; 49:85-92.
    • (2003) Arthritis Rheum , vol.49 , pp. 85-92
    • Ulanet, D.B.1    Wigley, F.M.2    Gelber, A.C.3    Rosen, A.4
  • 26
    • 0035019203 scopus 로고    scopus 로고
    • Oxygen desaturation on the sixminute walk test and mortality in untreated primary pulmonary hypertension
    • Paciocco G, Martinez FJ, Bossone E, et al. Oxygen desaturation on the sixminute walk test and mortality in untreated primary pulmonary hypertension. Eur Respir J 2001; 17:647-652.
    • (2001) Eur Respir J , vol.17 , pp. 647-652
    • Paciocco, G.1    Martinez, F.J.2    Bossone, E.3
  • 27
    • 33846315959 scopus 로고    scopus 로고
    • Six-minute walk test for the evaluation of pulmonary disease severity in scleroderma patients
    • Villalba WO, Sampaio-Barros PD, Pereira MC, et al. Six-minute walk test for the evaluation of pulmonary disease severity in scleroderma patients. Chest 2007; 131:217-222.
    • (2007) Chest , vol.131 , pp. 217-222
    • Villalba, W.O.1    Sampaio-Barros, P.D.2    Pereira, M.C.3
  • 28
    • 29144536869 scopus 로고    scopus 로고
    • Early detection of pulmonary arterial hypertension in systemic sclerosis: A French nationwide prospective multicenter study
    • Hachulla E, Gressin V, Guillevin L, et al. Early detection of pulmonary arterial hypertension in systemic sclerosis: a French nationwide prospective multicenter study. Arthritis Rheum 2005; 52:3792-3800.
    • (2005) Arthritis Rheum , vol.52 , pp. 3792-3800
    • Hachulla, E.1    Gressin, V.2    Guillevin, L.3
  • 29
    • 17144452827 scopus 로고    scopus 로고
    • Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease: A randomized, controlled trial
    • Badesch DB, Tapson VF, McGoon MD, et al. Continuous intravenous epoprostenol for pulmonary hypertension due to the scleroderma spectrum of disease: a randomized, controlled trial. Ann Intern Med 2000; 132:425-434.
    • (2000) Ann Intern Med , vol.132 , pp. 425-434
    • Badesch, D.B.1    Tapson, V.F.2    McGoon, M.D.3
  • 30
    • 4143121167 scopus 로고    scopus 로고
    • Treprostinil, a prostacyclin analogue, in pulmonary arterial hypertension associated with connective tissue disease
    • Oudiz RJ, Schilz RJ, Barst RJ, et al. Treprostinil, a prostacyclin analogue, in pulmonary arterial hypertension associated with connective tissue disease. Chest 2004; 126:420-427.
    • (2004) Chest , vol.126 , pp. 420-427
    • Oudiz, R.J.1    Schilz, R.J.2    Barst, R.J.3
  • 31
    • 0036682273 scopus 로고    scopus 로고
    • Inhaled iloprost for severe pulmonary hypertension
    • Olschewski H, Simonneau G, Galie N, et al. Inhaled iloprost for severe pulmonary hypertension. N Engl J Med 2002; 347:322-329.
    • (2002) N Engl J Med , vol.347 , pp. 322-329
    • Olschewski, H.1    Simonneau, G.2    Galie, N.3
  • 32
    • 0346492721 scopus 로고    scopus 로고
    • The endothelin system in pulmonary arterial hypertension
    • Galie N, Manes A, Branzi A. The endothelin system in pulmonary arterial hypertension. Cardiovasc Res 2004; 61:227-237.
    • (2004) Cardiovasc Res , vol.61 , pp. 227-237
    • Galie, N.1    Manes, A.2    Branzi, A.3
  • 33
    • 33750344748 scopus 로고    scopus 로고
    • Denton CP, Humbert M, Rubin L, Black CM. Bosentan treatment for pulmonary arterial hypertension related to connective tissue disease: a subgroup analysis of the pivotal clinical trials and their open-label extensions. Ann Rheum Dis 2006; 65:1336-1340. A post-hoc subgroup analysis of the ETRA bosentan in patients with SSc-PAH. The original study was a multicenter, randomized, controlled trial. Bosentan was the first oral therapy FDA approved specifically for the treatment of PAH.
    • Denton CP, Humbert M, Rubin L, Black CM. Bosentan treatment for pulmonary arterial hypertension related to connective tissue disease: a subgroup analysis of the pivotal clinical trials and their open-label extensions. Ann Rheum Dis 2006; 65:1336-1340. A post-hoc subgroup analysis of the ETRA bosentan in patients with SSc-PAH. The original study was a multicenter, randomized, controlled trial. Bosentan was the first oral therapy FDA approved specifically for the treatment of PAH.
  • 34
    • 25844531004 scopus 로고    scopus 로고
    • Long-term outcome of bosentan treatment in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with the scleroderma spectrum of diseases
    • Girgis RE, Mathai SC, Krishnan JA, et al. Long-term outcome of bosentan treatment in idiopathic pulmonary arterial hypertension and pulmonary arterial hypertension associated with the scleroderma spectrum of diseases. J Heart Lung Transplant 2005; 24:1626-1631.
    • (2005) J Heart Lung Transplant , vol.24 , pp. 1626-1631
    • Girgis, R.E.1    Mathai, S.C.2    Krishnan, J.A.3
  • 35
    • 22844436819 scopus 로고    scopus 로고
    • Ambrisentan therapy for pulmonary arterial hypertension
    • Galie N, Badesch D, Oudiz R, et al. Ambrisentan therapy for pulmonary arterial hypertension. J Am Coll Cardiol 2005; 46:529-535.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 529-535
    • Galie, N.1    Badesch, D.2    Oudiz, R.3
  • 36
    • 10744230817 scopus 로고    scopus 로고
    • Sitaxsentan therapy for pulmonary arterial hypertension
    • Barst RJ, Langleben D, Frost A, et al. Sitaxsentan therapy for pulmonary arterial hypertension. Am J Respir Crit Care Med 2004; 169:441-447.
    • (2004) Am J Respir Crit Care Med , vol.169 , pp. 441-447
    • Barst, R.J.1    Langleben, D.2    Frost, A.3
  • 37
    • 34948865560 scopus 로고    scopus 로고
    • Selective endothelinA receptor antagonism with sitaxsentan for pulmonary arterial hypertension associated with connective tissue disease
    • 1 May [Epub ahead of print, An evaluation of a novel selective ETRA in patients with connective tissue disease
    • Girgis RE, Frost AE, Hill NS, Horn EM, Langleben D, Mc L, V, Oudiz RJ, Robbins IM, Seibold JR, Shapiro S, Tapson VF, Barst RJ. Selective endothelinA receptor antagonism with sitaxsentan for pulmonary arterial hypertension associated with connective tissue disease. Ann Rheum Dis 2007; 1 May [Epub ahead of print]. An evaluation of a novel selective ETRA in patients with connective tissue disease.
    • (2007) Ann Rheum Dis
    • Girgis, R.E.1    Frost, A.E.2    Hill, N.S.3    Horn, E.M.4    Langleben, D.5    Mc, L.V.6    Oudiz, R.J.7    Robbins, I.M.8    Seibold, J.R.9    Shapiro, S.10    Tapson, V.F.11    Barst, R.J.12
  • 38
    • 26444534291 scopus 로고    scopus 로고
    • Sildenafil citrate therapy for pulmonary arterial hypertension
    • Galie N, Ghofrani HA, Torbicki A, et al. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med 2005; 353:2148-2157.
    • (2005) N Engl J Med , vol.353 , pp. 2148-2157
    • Galie, N.1    Ghofrani, H.A.2    Torbicki, A.3
  • 39
    • 33845526777 scopus 로고    scopus 로고
    • Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension
    • McLaughlin VV, Oudiz RJ, Frost A, et al. Randomized study of adding inhaled iloprost to existing bosentan in pulmonary arterial hypertension. Am J Respir Crit Care Med 2006; 174:1257-1263.
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1257-1263
    • McLaughlin, V.V.1    Oudiz, R.J.2    Frost, A.3
  • 40
    • 33847743922 scopus 로고    scopus 로고
    • Addition of sildenafil to bosentan monotherapy in pulmonary arterial hypertension
    • Mathai SC, Girgis RE, Fisher MR, et al. Addition of sildenafil to bosentan monotherapy in pulmonary arterial hypertension. Eur Respir J 2007; 29:469-475.
    • (2007) Eur Respir J , vol.29 , pp. 469-475
    • Mathai, S.C.1    Girgis, R.E.2    Fisher, M.R.3
  • 41
    • 33845660778 scopus 로고    scopus 로고
    • Lung transplantation in scleroderma compared with idiopathic pulmonary fibrosis and idiopathic pulmonary arterial hypertension
    • Schachna L, Medsger TA Jr, Dauber JH, et al. Lung transplantation in scleroderma compared with idiopathic pulmonary fibrosis and idiopathic pulmonary arterial hypertension. Arthritis Rheum 2006; 54:3954-3961.
    • (2006) Arthritis Rheum , vol.54 , pp. 3954-3961
    • Schachna, L.1    Medsger Jr, T.A.2    Dauber, J.H.3
  • 42
    • 33745277147 scopus 로고    scopus 로고
    • Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis
    • Demonstration of autoantibodies to the PDGF receptor in patients with SSc. This is a potential mechanism of disease in PAH and could open the door to novel therapies directed at the vascular remodeling that occurs in SSc
    • Baroni SS, Santillo M, Bevilacqua F, et al. Stimulatory autoantibodies to the PDGF receptor in systemic sclerosis. N Engl J Med 2006; 354:2667-2676. Demonstration of autoantibodies to the PDGF receptor in patients with SSc. This is a potential mechanism of disease in PAH and could open the door to novel therapies directed at the vascular remodeling that occurs in SSc.
    • (2006) N Engl J Med , vol.354 , pp. 2667-2676
    • Baroni, S.S.1    Santillo, M.2    Bevilacqua, F.3
  • 43
    • 26444540768 scopus 로고    scopus 로고
    • Schermuly RT, Dony E, Ghofrani HA, et al. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 2005; 115:2811-2821.
    • Schermuly RT, Dony E, Ghofrani HA, et al. Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 2005; 115:2811-2821.
  • 44
    • 25444484658 scopus 로고    scopus 로고
    • Imatinib for the treatment of pulmonary arterial hypertension
    • Ghofrani HA, Seeger W, Grimminger F. Imatinib for the treatment of pulmonary arterial hypertension. N Engl J Med 2005; 353:1412-1413.
    • (2005) N Engl J Med , vol.353 , pp. 1412-1413
    • Ghofrani, H.A.1    Seeger, W.2    Grimminger, F.3
  • 45
    • 33745637694 scopus 로고    scopus 로고
    • Williams MH, Das C, Handler CE, et al. Systemic sclerosis associated pulmonary hypertension: improved survival in the current era. Heart 2006; 92:926-932. A comparison of current patient outcomes and historical controls.
    • Williams MH, Das C, Handler CE, et al. Systemic sclerosis associated pulmonary hypertension: improved survival in the current era. Heart 2006; 92:926-932. A comparison of current patient outcomes and historical controls.


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