Chlamydial lipopolysaccharide is present in serum during acute coronary syndrome and correlates with CRP levels

Atherosclerosis

Volumn 194, Issue 2, 2007, Pages 403-407

  Tiirola, Terttu ^a   Sinisalo, Juha ^b   Nieminen, Markku S ^b   Silvennoinen Kassinen, Sylvi ^c   Paldanius, Mika ^a   Saikku, Pekka ^c   Jauhiainen, Matti ^a   Leinonen, Maija ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c UNIVERSITY OF OULU   (Finland)

Author keywords

Acute coronary syndrome; Chlamydia pneumoniae; Chlamydial lipopolysaccharide; Highly sensitive C reactive protein; Inflammation

Indexed keywords

C REACTIVE PROTEIN; LIPOPOLYSACCHARIDE;

ACUTE CORONARY SYNDROME; ARTICLE; CHLAMYDOPHILA PNEUMONIAE; CORRELATION ANALYSIS; FOLLOW UP; HUMAN; INFLAMMATION; PRIORITY JOURNAL; TISSUE INJURY;

ACUTE CORONARY SYNDROME; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CHLAMYDIA INFECTIONS; CHLAMYDOPHILA PNEUMONIAE; FEMALE; HUMANS; LIPOPOLYSACCHARIDES; LONGITUDINAL STUDIES; MALE; MIDDLE AGED;

EID: 34948842035     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2006.08.013     Document Type: Article

References (25)

1. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 340 (1999) 115-126
2. Bassuk S.S., Rifai N., and Ridker P.M. High-sensitivity C-reactive protein: clinical importance. Curr Probl Cardiol 29 (2004) 439-493
3. Leinonen M., and Saikku P. Evidence for infectious agents in cardiovascular disease and atherosclerosis. Lancet Infect Dis 2 (2002) 11-17
4. Huittinen T., Leinonen M., Tenkanen L., et al. Autoimmunity to human heat shock protein 60, Chlamydia pneumoniae infection, and inflammation in predicting coronary risk. Arterioscler Thromb Vasc Biol 22 (2002) 431-437
5. Tiirola T., Jaakkola A., Bloigu A., et al. Novel enzyme immunoassay utilizing lipopolysaccharide-binding protein as a capture molecule for the measurement of chlamydial lipopolysaccharide in serum. Diagn Microbiol Infect Dis 54 (2006) 7-12
6. Miller S.I., Ernst R.K., and Bader M.W. LPS, TLR4 and infectious disease diversity. Nat Rev Microbiol 3 (2005) 36-46
7. Sinisalo J., Mattila K., Valtonen V., et al. Effect of 3 months of antimicrobial treatment with clarithromycin in acute non-q-wave coronary syndrome. Circulation 105 (2002) 1555-1560
8. Leinonen M., Tiirola T., Jauhiainen M., et al. Chlamydial lipopolysaccharide levels correlate to the levels of acute phase proteins and troponin in the sera of patients with acute myocardial infarction or unstable angina pectoris. In: Chernesky M., et al. (Ed). Proceedings of the international chlamydial symposium on chlamydial infections. San Francisco, CA 94110, USA (2006) 399-403
9. Murray L.J., O'Reilly D.P., Ong G.M., et al. Chlamydia pneumoniae antibodies are associated with an atherogenic lipid profile. Heart 81 (1999) 239-244
10. Laurila A., Bloigu A., Näyhä S., et al. Chronic Chlamydia pneumoniae infection is associated with a serum lipid profile known to be a risk factor for atherosclerosis. Arterioscler Thromb Vasc Biol 17 (1997) 2910-2913
11. Kaklikkaya I., Kaklikkaya N., Buruk K., et al. Investigation of Chlamydia pneumoniae DNA, chlamydial lipopolysaccharide antigens, and Helicobacter pylori DNA in atherosclerotic plaques of patients with aortoiliac occlusive disease. Cardiovasc Pathol 15 (2006) 105-109
12. Kuo C.C., Gown A.M., Benditt E.P., and Grayston J.T. Detection of Chlamydia pneumoniae in aortic lesions of atherosclerosis by immunocytochemical stain. Arterioscler Thromb 13 (1993) 1501-1504
13. Tiran A., Tio R.A., Ossewaarde J.M., et al. Coronary angioplasty induces rise in Chlamydia pneumoniae-specific antibodies. J Clin Microbiol 37 (1999) 1013-1017
14. Poppert S., Schlaupitz K., Marre R., et al. Chlamydia pneumoniae in an ex vivo human artery culture model. Atherosclerosis (2005)
15. Saikku P., Leinonen M., Mattila K., et al. Serological evidence of an association of a novel Chlamydia, TWAR, with chronic coronary heart disease and acute myocardial infarction. Lancet 2 (1988) 983-986
16. Leinonen M., Linnanmäki E., Mattila K., et al. Circulating immune complexes containing chlamydial lipopolysaccharide in acute myocardial infarction. Microb Pathog 9 (1990) 67-73
17. Heumann D., and Roger T. Initial responses to endotoxins and Gram-negative bacteria. Clin Chim Acta 323 (2002) 59-72
18. Ingalls R.R., Rice P.A., Qureshi N., et al. The inflammatory cytokine response to Chlamydia trachomatis infection is endotoxin mediated. Infect Immun 63 (1995) 3125-3130
19. Calabro P., Willerson J.T., and Yeh E.T. Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation 108 (2003) 1930-1932
20. Jialal I., Devaraj S., and Singh U. Sources of CRP in atherosclerotic lesions. Am J Pathol 168 (2006) 1054-1055 [author reply 1055-6]
21. Wiedermann C.J., Kiechl S., Dunzendorfer S., et al. Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the Bruneck Study. J Am Coll Cardiol 34 (1999) 1975-1981
22. Paju S., Pussinen P.J., Sinisalo J., et al. Clarithromycin reduces recurrent cardiovascular events in subjects without periodontitis. Atherosclerosis 188 (2006) 412-419
23. Anderson J.L. Infection, antibiotics, and atherothrombosis-end of the road or new beginnings?. N Engl J Med 352 (2005) 1706-1709
24. Grayston J.T., Kronmal R.A., Jackson L.A., et al. Azithromycin for the secondary prevention of coronary events. N Engl J Med 352 (2005) 1637-1645
25. Törmäkangas L., Alakärppä H., David D.B., Leinonen M., and Saikku P. Telithromycin treatment of chronic Chlamydia pneumoniae infection in C57BL/6J mice. Antimicrob Agents Chemother 48 (2004) 3655-3661