메뉴 건너뛰기




Volumn 40, Issue 3, 2007, Pages 188-200

Immunogenicity and protection against genital Chlamydia infection and its complications by a multisubunit candidate vaccine

Author keywords

Bacterial outer membrane proteins; Bacterial vaccines; Chlamydia infections; Porins; Vaccination

Indexed keywords

BACTERIAL VACCINE; DRUG CARRIER; GAMMA INTERFERON; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G2A; MAJOR OUTER MEMBRANE PROTEIN; OUTER MEMBRANE PROTEIN; PORIN; UNCLASSIFIED DRUG; VIBRIO CHOLERA GHOST;

EID: 34948841459     PISSN: 16841182     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (39)

References (53)
  • 1
    • 0032716557 scopus 로고    scopus 로고
    • Transgene as vaccine for Chlamydia
    • Brunham RC, Zhang DJ. Transgene as vaccine for Chlamydia. Am Heart J. 1999;138:S519-22.
    • (1999) Am Heart J , vol.138
    • Brunham, R.C.1    Zhang, D.J.2
  • 3
    • 0031969788 scopus 로고    scopus 로고
    • Vaccines against Chlamydia: Approaches and progress
    • Stagg AJ. Vaccines against Chlamydia: approaches and progress. Mol Med Today. 1998;4:166-73.
    • (1998) Mol Med Today , vol.4 , pp. 166-173
    • Stagg, A.J.1
  • 5
    • 0037653584 scopus 로고    scopus 로고
    • Contemporary approaches to designing and evaluating vaccines against Chlamydia
    • Igietseme JU, Eko FO, Black CM. Contemporary approaches to designing and evaluating vaccines against Chlamydia. Expert Rev Vaccines. 2003;2:129-46.
    • (2003) Expert Rev Vaccines , vol.2 , pp. 129-146
    • Igietseme, J.U.1    Eko, F.O.2    Black, C.M.3
  • 6
    • 0036263421 scopus 로고    scopus 로고
    • Immunity to murine chlamydial genital infection
    • Morrison RP, Caldwell HD. Immunity to murine chlamydial genital infection. Infect Immun. 2002;70:2741-51.
    • (2002) Infect Immun , vol.70 , pp. 2741-2751
    • Morrison, R.P.1    Caldwell, H.D.2
  • 7
    • 0029145563 scopus 로고
    • Protective efficacy of a parenterally administered MOMP-derived synthetic oligopeptide vaccine in a murine model of Chlamydia trachomatis genital tract infection: Serum neutralizing IgG antibodies do not protect against Chlamydial genital tract infection
    • Su H, Parnell M, Caldwell HD. Protective efficacy of a parenterally administered MOMP-derived synthetic oligopeptide vaccine in a murine model of Chlamydia trachomatis genital tract infection: serum neutralizing IgG antibodies do not protect against Chlamydial genital tract infection. Vaccine. 1995;13:1023-32.
    • (1995) Vaccine , vol.13 , pp. 1023-1032
    • Su, H.1    Parnell, M.2    Caldwell, H.D.3
  • 8
    • 0031470928 scopus 로고    scopus 로고
    • Studies in knockout mice reveal that anti-chlamydial protection requires TH1 cells producing IFN-gamma: Is this true for humans?
    • Johansson M, Schon K, Ward M, Lycke N. Studies in knockout mice reveal that anti-chlamydial protection requires TH1 cells producing IFN-gamma: is this true for humans? Scand J Immunol. 1997;46:546-52.
    • (1997) Scand J Immunol , vol.46 , pp. 546-552
    • Johansson, M.1    Schon, K.2    Ward, M.3    Lycke, N.4
  • 9
    • 0031020913 scopus 로고    scopus 로고
    • Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response
    • Johansson M, Schon K, Ward M, Lycke N. Genital tract infection with Chlamydia trachomatis fails to induce protective immunity in gamma interferon receptor-deficient mice despite a strong local immunoglobulin A response. Infect Immun. 1997; 65:1032-44.
    • (1997) Infect Immun , vol.65 , pp. 1032-1044
    • Johansson, M.1    Schon, K.2    Ward, M.3    Lycke, N.4
  • 10
    • 0030988438 scopus 로고    scopus 로고
    • Dissemination of Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice
    • Cotter TW, Ramsey KH, Miranpuri GS, Poulsen CE, Byrne GI. Dissemination of Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice. Infect Immun. 1997;65:2145-52.
    • (1997) Infect Immun , vol.65 , pp. 2145-2152
    • Cotter, T.W.1    Ramsey, K.H.2    Miranpuri, G.S.3    Poulsen, C.E.4    Byrne, G.I.5
  • 12
    • 0034444896 scopus 로고    scopus 로고
    • Immunity to murine Chlamydia trachomatis genital tract reinfection involves B cells and CD4+ T cells but not CDS+ T cells
    • Morrison SG, Su H, Caldwell HD, Morrison RP. Immunity to murine Chlamydia trachomatis genital tract reinfection involves B cells and CD4+ T cells but not CDS+ T cells. Infect Immun. 2000;68:6979-87.
    • (2000) Infect Immun , vol.68 , pp. 6979-6987
    • Morrison, S.G.1    Su, H.2    Caldwell, H.D.3    Morrison, R.P.4
  • 13
    • 0036169311 scopus 로고    scopus 로고
    • Fc receptor regulation of protective immunity against Chlamydia trachomatis
    • Moore T, Ananaba GA, Bolier J, Bowers S, Belay T, Eko FO, et al. Fc receptor regulation of protective immunity against Chlamydia trachomatis. Immunology. 2002;105:213-21.
    • (2002) Immunology , vol.105 , pp. 213-221
    • Moore, T.1    Ananaba, G.A.2    Bolier, J.3    Bowers, S.4    Belay, T.5    Eko, F.O.6
  • 14
    • 1042268186 scopus 로고    scopus 로고
    • Antibody regulation of T-cell immunity: Implications for vaccine strategies against intracellular pathogens
    • Igietseme JU, Eko FO, He Q, Black CM. Antibody regulation of T-cell immunity: implications for vaccine strategies against intracellular pathogens. Expert Rev Vaccines. 2004;3:23-34.
    • (2004) Expert Rev Vaccines , vol.3 , pp. 23-34
    • Igietseme, J.U.1    Eko, F.O.2    He, Q.3    Black, C.M.4
  • 15
    • 0028032538 scopus 로고
    • Chlamydia trachomatis antigens: Role in immunity and pathogenesis
    • Brunham RC, Peeling RW. Chlamydia trachomatis antigens: role in immunity and pathogenesis. Infect Agents Dis. 1994;3:218-33.
    • (1994) Infect Agents Dis , vol.3 , pp. 218-233
    • Brunham, R.C.1    Peeling, R.W.2
  • 16
    • 0027787591 scopus 로고
    • Partial protection against genital reinfection by immunization of guinea-pigs with isolated outer-membrane proteins of the chlamydial agent of guinea-pig inclusion conjunctivitis
    • Batteiger BE, Rank RG, Bavoil PM, Soderberg LS. Partial protection against genital reinfection by immunization of guinea-pigs with isolated outer-membrane proteins of the chlamydial agent of guinea-pig inclusion conjunctivitis. J Gen Microbiol. 1993;139:2965-72.
    • (1993) J Gen Microbiol , vol.139 , pp. 2965-2972
    • Batteiger, B.E.1    Rank, R.G.2    Bavoil, P.M.3    Soderberg, L.S.4
  • 17
    • 0026641598 scopus 로고
    • Heterotypic protection of mice against chlamydial salpingitis and colonization of the lower genital tract with a human serovar F isolate of Chlamydia trachomatis by prior immunization with recombinant serovar L1 major outer membrane protein
    • Tuffrey M, Alexander F, Conlan W, Woods C, Ward M. Heterotypic protection of mice against chlamydial salpingitis and colonization of the lower genital tract with a human serovar F isolate of Chlamydia trachomatis by prior immunization with recombinant serovar L1 major outer membrane protein. J Gen Microbiol. 1992;138:1707-15.
    • (1992) J Gen Microbiol , vol.138 , pp. 1707-1715
    • Tuffrey, M.1    Alexander, F.2    Conlan, W.3    Woods, C.4    Ward, M.5
  • 18
    • 0029079615 scopus 로고
    • A peptide of Chlamydia trachomatis shown to be a primary T-cell epitope in vitro induces cell-mediated immunity in vivo
    • Knight SC, Iqball S, Woods C, Stagg A, Ward ME, Tuffrey M. A peptide of Chlamydia trachomatis shown to be a primary T-cell epitope in vitro induces cell-mediated immunity in vivo. Immunology 1995;85:8-15.
    • (1995) Immunology , vol.85 , pp. 8-15
    • Knight, S.C.1    Iqball, S.2    Woods, C.3    Stagg, A.4    Ward, M.E.5    Tuffrey, M.6
  • 19
    • 0037413959 scopus 로고    scopus 로고
    • Recombinant Vibrio cholerae ghosts as a delivery vehicle for vaccinating against Chlamydia trachomatis
    • Eko FO, Lubitz W, McMillan L, Ramey K, Moore TT, Ananaba GA, et al. Recombinant Vibrio cholerae ghosts as a delivery vehicle for vaccinating against Chlamydia trachomatis. Vaccine. 2003;21:1694-703.
    • (2003) Vaccine , vol.21 , pp. 1694-1703
    • Eko, F.O.1    Lubitz, W.2    McMillan, L.3    Ramey, K.4    Moore, T.T.5    Ananaba, G.A.6
  • 20
    • 0034819712 scopus 로고    scopus 로고
    • Immunization with the Chlamydia trachomatis mouse pneumonitis major outer membrane protein can elicit a protective immune response against a genital challenge
    • Pal S, Theodor I, Peterson EM, de la Maza LM. Immunization with the Chlamydia trachomatis mouse pneumonitis major outer membrane protein can elicit a protective immune response against a genital challenge. Infect Immun. 2001;69:6240-7.
    • (2001) Infect Immun , vol.69 , pp. 6240-6247
    • Pal, S.1    Theodor, I.2    Peterson, E.M.3    de la Maza, L.M.4
  • 21
    • 0021288383 scopus 로고
    • Structural and polypeptide differences between envelopes of infective and reproductive life cycle forms of Chlamydia spp
    • Hatch TP, Allan I, Pearce JH. Structural and polypeptide differences between envelopes of infective and reproductive life cycle forms of Chlamydia spp. J Bacteriol. 1984;157:13-20.
    • (1984) J Bacteriol , vol.157 , pp. 13-20
    • Hatch, T.P.1    Allan, I.2    Pearce, J.H.3
  • 22
    • 0003042150 scopus 로고
    • Human immune response to Chlamydia trachomatis infections
    • Oriel J, Ridgway G, Schachter J, Taylor-Robinson D, Ward M, eds, London, UK: Cambridge University Press;
    • Jones RB, Batteiger BE. Human immune response to Chlamydia trachomatis infections. In: Oriel J, Ridgway G, Schachter J, Taylor-Robinson D, Ward M, eds. Chlamydial infections. London, UK: Cambridge University Press; 1986: 423-32.
    • (1986) Chlamydial infections , pp. 423-432
    • Jones, R.B.1    Batteiger, B.E.2
  • 23
    • 0026740257 scopus 로고
    • Chlamydial vaccines - future trends
    • Ward ME. Chlamydial vaccines - future trends. J Infect. 1992; 25(Suppl. 1):11-26.
    • (1992) J Infect , vol.25 , Issue.SUPPL. 1 , pp. 11-26
    • Ward, M.E.1
  • 25
    • 0032561496 scopus 로고    scopus 로고
    • Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis
    • Stephens RS, Kaiman S, Lammel C, Fan J, Marathe R, Aravind L, et al. Genome sequence of an obligate intracellular pathogen of humans: Chlamydia trachomatis. Science. 1998;282:754-9.
    • (1998) Science , vol.282 , pp. 754-759
    • Stephens, R.S.1    Kaiman, S.2    Lammel, C.3    Fan, J.4    Marathe, R.5    Aravind, L.6
  • 26
    • 0034048999 scopus 로고    scopus 로고
    • Chlamydial genomics and vaccine antigen discovery
    • Stephens RS. Chlamydial genomics and vaccine antigen discovery. J Infect Dis. 2000;181(Suppl. 3):S521-3.
    • (2000) J Infect Dis , vol.181 , Issue.SUPPL. 3
    • Stephens, R.S.1
  • 27
    • 0032037664 scopus 로고    scopus 로고
    • Molecular cloning and characterization of the genes coding for the highly immunogenic cluster of 90-kilodalton envelope proteins from the Chlamydia psittaci subtype that causes abortion in sheep
    • Longbottom D, Russell M, Dunbar SM, Jones GE, Herring AJ. Molecular cloning and characterization of the genes coding for the highly immunogenic cluster of 90-kilodalton envelope proteins from the Chlamydia psittaci subtype that causes abortion in sheep. Infect Immun. 1998;66:1317-24.
    • (1998) Infect Immun , vol.66 , pp. 1317-1324
    • Longbottom, D.1    Russell, M.2    Dunbar, S.M.3    Jones, G.E.4    Herring, A.J.5
  • 28
    • 0035077459 scopus 로고    scopus 로고
    • Expression of Chlamydia pneumoniae polymorphic membrane protein family genes
    • Grimwood J, Olinger L, Stephens RS. Expression of Chlamydia pneumoniae polymorphic membrane protein family genes. Infect Immun. 2001;69:2383-9.
    • (2001) Infect Immun , vol.69 , pp. 2383-2389
    • Grimwood, J.1    Olinger, L.2    Stephens, R.S.3
  • 29
    • 0037898179 scopus 로고    scopus 로고
    • Polymorphic membrane protein (PMP) 20 and PMP 21 of Chlamydia pneumoniae induce proinflammatory mediators in human endothelial cells in vitro by activation of the nuclear factor-kappaB pathway
    • Niessner A, Kaun C, Zorn G, Speidl W, Türel Z, Christiansen G, et al. Polymorphic membrane protein (PMP) 20 and PMP 21 of Chlamydia pneumoniae induce proinflammatory mediators in human endothelial cells in vitro by activation of the nuclear factor-kappaB pathway. J Infect Dis. 2003;188:108-13.
    • (2003) J Infect Dis , vol.188 , pp. 108-113
    • Niessner, A.1    Kaun, C.2    Zorn, G.3    Speidl, W.4    Türel, Z.5    Christiansen, G.6
  • 30
    • 0033637488 scopus 로고    scopus 로고
    • Characterization and functional analysis of PorB, a Chlamydia porin and neutralizing target
    • Kubo A, Stephens RS. Characterization and functional analysis of PorB, a Chlamydia porin and neutralizing target. Mol Microbiol. 2000;38:772-80.
    • (2000) Mol Microbiol , vol.38 , pp. 772-780
    • Kubo, A.1    Stephens, R.S.2
  • 31
    • 0035164734 scopus 로고    scopus 로고
    • Substrate-specific diffusion of select dicarboxylates through Chlamydia trachomatis PorB
    • Kubo A, Stephens RS. Substrate-specific diffusion of select dicarboxylates through Chlamydia trachomatis PorB. Microbiology. 2001;147:3135-40.
    • (2001) Microbiology , vol.147 , pp. 3135-3140
    • Kubo, A.1    Stephens, R.S.2
  • 32
    • 0037094024 scopus 로고    scopus 로고
    • Antigenic topology of chlamydial PorB protein and identification of targets for immune neutralization of infectivity
    • Kawa DE, Stephens RS. Antigenic topology of chlamydial PorB protein and identification of targets for immune neutralization of infectivity. J Immunol. 2002;168:5184-91.
    • (2002) J Immunol , vol.168 , pp. 5184-5191
    • Kawa, D.E.1    Stephens, R.S.2
  • 33
    • 4944232957 scopus 로고    scopus 로고
    • Immune response to the Chlamydia trachomatis outer membrane protein PorB
    • Kawa DE, Schachter J, Stephens RS. Immune response to the Chlamydia trachomatis outer membrane protein PorB. Vaccine. 2004;22:4282-6.
    • (2004) Vaccine , vol.22 , pp. 4282-4286
    • Kawa, D.E.1    Schachter, J.2    Stephens, R.S.3
  • 35
    • 0023933501 scopus 로고
    • Resolution of chlamydial genital infection in B-cell-deficient mice and immunity to reinfection
    • Ramsey KH, Soderberg LS, Rank RG. Resolution of chlamydial genital infection in B-cell-deficient mice and immunity to reinfection. Infect Immun. 1988;56:1320-5.
    • (1988) Infect Immun , vol.56 , pp. 1320-1325
    • Ramsey, K.H.1    Soderberg, L.S.2    Rank, R.G.3
  • 36
    • 0026707347 scopus 로고
    • Complete sequence of the major outer membrane protein-encoding gene of Chlamydia trachomatis serovar Da
    • Sayada C, Denamur E, Elion J. Complete sequence of the major outer membrane protein-encoding gene of Chlamydia trachomatis serovar Da. Gene. 1992;120:129-30.
    • (1992) Gene , vol.120 , pp. 129-130
    • Sayada, C.1    Denamur, E.2    Elion, J.3
  • 37
    • 0031871384 scopus 로고    scopus 로고
    • Phylogenetic analysis of the Chlamydia trachomatis major outer membrane protein and examination of potential pathogenic determinants
    • Stothard DR, Boguslawski G, Jones RB. Phylogenetic analysis of the Chlamydia trachomatis major outer membrane protein and examination of potential pathogenic determinants. Infect Immun. 1998;66:3618-25.
    • (1998) Infect Immun , vol.66 , pp. 3618-3625
    • Stothard, D.R.1    Boguslawski, G.2    Jones, R.B.3
  • 39
    • 0034730592 scopus 로고    scopus 로고
    • Characterization and immunogenicity of Vibrio cholerae ghosts expressing toxin-coregulated pili
    • Eko FO, Mayr UB, Attridge SR, Lubitz W. Characterization and immunogenicity of Vibrio cholerae ghosts expressing toxin-coregulated pili. J Biotechnol. 2000;83:115-23.
    • (2000) J Biotechnol , vol.83 , pp. 115-123
    • Eko, F.O.1    Mayr, U.B.2    Attridge, S.R.3    Lubitz, W.4
  • 40
    • 0022478013 scopus 로고
    • Vector for regulated expression of cloned genes in a wide range of gram-negative bacteria
    • Mermod N, Ramos JL, Lehrbach PR, Timmis KN. Vector for regulated expression of cloned genes in a wide range of gram-negative bacteria. J Bacteriol. 1986;167:447-54.
    • (1986) J Bacteriol , vol.167 , pp. 447-454
    • Mermod, N.1    Ramos, J.L.2    Lehrbach, P.R.3    Timmis, K.N.4
  • 41
    • 0027935982 scopus 로고
    • Production of Vibrio cholerae ghosts (VCG) by expression of a cloned phage lysis gene: Potential for vaccine development
    • Eko FO, Szostak MP, Wanner G, Lubitz W. Production of Vibrio cholerae ghosts (VCG) by expression of a cloned phage lysis gene: potential for vaccine development. Vaccine. 1994; 12:1231-7.
    • (1994) Vaccine , vol.12 , pp. 1231-1237
    • Eko, F.O.1    Szostak, M.P.2    Wanner, G.3    Lubitz, W.4
  • 42
    • 0024341592 scopus 로고
    • Humoral immune response to chlamydial genital infection of mice with the agent of mouse pneumonitis
    • Ramsey KH, Newhall WJ 5th, Rank RG. Humoral immune response to chlamydial genital infection of mice with the agent of mouse pneumonitis. Infect Immun. 1989;57:2441-6.
    • (1989) Infect Immun , vol.57 , pp. 2441-2446
    • Ramsey, K.H.1    Newhall 5th, W.J.2    Rank, R.G.3
  • 43
    • 0028085578 scopus 로고
    • Protection against infertility in a BALB/c mouse salpingitis model by intranasal immunization with a mouse pneumonitis biovar of Chlamydia trachomatis
    • Pal S, Fielder TJ, Peterson EM, de la Maza LM. Protection against infertility in a BALB/c mouse salpingitis model by intranasal immunization with a mouse pneumonitis biovar of Chlamydia trachomatis. Infect Immun. 1994;62:3354-62.
    • (1994) Infect Immun , vol.62 , pp. 3354-3362
    • Pal, S.1    Fielder, T.J.2    Peterson, E.M.3    de la Maza, L.M.4
  • 44
    • 0031669414 scopus 로고    scopus 로고
    • Route of infection that induces a high intensity of gamma interferon-secreting T cells in the genital tract produces optimal protection against Chlamydia trachomatis infection in mice
    • Igietseme JU, Uriri IM, Kumar SN, Ananaba GA, Ojior OO, Momodu IA, et al. Route of infection that induces a high intensity of gamma interferon-secreting T cells in the genital tract produces optimal protection against Chlamydia trachomatis infection in mice. Infect Immun. 1998;66:4030-5.
    • (1998) Infect Immun , vol.66 , pp. 4030-4035
    • Igietseme, J.U.1    Uriri, I.M.2    Kumar, S.N.3    Ananaba, G.A.4    Ojior, O.O.5    Momodu, I.A.6
  • 45
    • 0025974551 scopus 로고
    • Susceptibility to reinfection after a primary chlamydial genital infection is associated with a decrease of antigen-specific T cells in the genital tract
    • Igietseme JU, Rank RG. Susceptibility to reinfection after a primary chlamydial genital infection is associated with a decrease of antigen-specific T cells in the genital tract. Infect Immun. 1991;59:1346-51.
    • (1991) Infect Immun , vol.59 , pp. 1346-1351
    • Igietseme, J.U.1    Rank, R.G.2
  • 46
    • 0024505397 scopus 로고
    • Protective role of serum antibody in immunity to chlamydial genital infection
    • Rank RG, Batteiger BE. Protective role of serum antibody in immunity to chlamydial genital infection. Infect Immun. 1989; 57:299-301.
    • (1989) Infect Immun , vol.57 , pp. 299-301
    • Rank, R.G.1    Batteiger, B.E.2
  • 47
    • 0242468265 scopus 로고    scopus 로고
    • Induction of protective immunity against a Chlamydia trachomatis genital infection in three genetically distinct strains of mice
    • Pal S, Peterson EM, de la Maza LM. Induction of protective immunity against a Chlamydia trachomatis genital infection in three genetically distinct strains of mice. Immunology. 2003; 110:368-75.
    • (2003) Immunology , vol.110 , pp. 368-375
    • Pal, S.1    Peterson, E.M.2    de la Maza, L.M.3
  • 48
  • 49
    • 0031081378 scopus 로고    scopus 로고
    • Endotoxicity does not limit the use of bacterial ghosts as candidate vaccines
    • Mader HJ, Szostak MP, Hensel A, Lubitz W, Haslberger AG. Endotoxicity does not limit the use of bacterial ghosts as candidate vaccines. Vaccine. 1997;15:195-202.
    • (1997) Vaccine , vol.15 , pp. 195-202
    • Mader, H.J.1    Szostak, M.P.2    Hensel, A.3    Lubitz, W.4    Haslberger, A.G.5
  • 50
    • 0037070113 scopus 로고    scopus 로고
    • Toll-like receptors as adjuvant receptors
    • Kaisho T, Akira S. Toll-like receptors as adjuvant receptors. Biochim Biophys Acta. 2002;1589:1-13.
    • (2002) Biochim Biophys Acta , vol.1589 , pp. 1-13
    • Kaisho, T.1    Akira, S.2
  • 52
    • 0022474844 scopus 로고
    • Salpingitis in mice induced by human strains of Chlamydia trachomatis
    • Tuffrey M, Falder P, Gale J, Taylor-Robinson D. Salpingitis in mice induced by human strains of Chlamydia trachomatis. Br J Exp Pathol. 1986;67:605-16.
    • (1986) Br J Exp Pathol , vol.67 , pp. 605-616
    • Tuffrey, M.1    Falder, P.2    Gale, J.3    Taylor-Robinson, D.4
  • 53
    • 0025364578 scopus 로고
    • Severity of salpingitis in mice after primary and repeated inoculation with a human strain of Chlamydia trachomatis
    • Tuffrey M, Alexander F, Taylor-Robinson D. Severity of salpingitis in mice after primary and repeated inoculation with a human strain of Chlamydia trachomatis. J Exp Pathol (Oxford). 1990;71:403-10.
    • (1990) J Exp Pathol (Oxford) , vol.71 , pp. 403-410
    • Tuffrey, M.1    Alexander, F.2    Taylor-Robinson, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.