A preliminary study of dopamine transporter binding in bipolar and unipolar depressed patients and healthy controls

Neuropsychobiology

Volumn 55, Issue 3-4, 2007, Pages 167-170

  Amsterdam, Jay D ^a,c   Newberg, Andrew B ^b  

^a Depression Research Unit

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c The Science Center Philadelphia   (United States)

Author keywords

99mTc TRODAT 1; Bipolar disorder; Depression; Dopamine transporter; Single photon emission computed tomography

Indexed keywords

[2 [[2 [[[3 (4 CHLOROPHENYL) 8 METHYL 8 AZABICYCLO[3.2.1]OCT 2 YL]METHYL](2 MERCAPTOETHYL)AMINO]ETHYL]AMINO]ETHANETHIOLATO]OXOTECHNETIUM TC 99M; DOPAMINE TRANSPORTER;

ADULT; ARTICLE; BINDING AFFINITY; BIPOLAR DEPRESSION; BRAIN REGION; CAUDATE NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DOPAMINERGIC TRANSMISSION; FEMALE; HUMAN; LIGAND BINDING; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; PUTAMEN; RECEPTOR AFFINITY; RECEPTOR DENSITY; RECEPTOR INTRINSIC ACTIVITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STRIATE CORTEX;

ADULT; DEPRESSION; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; FUNCTIONAL LATERALITY; HUMANS; MALE; ORGANOTECHNETIUM COMPOUNDS; PUTAMEN; RADIOPHARMACEUTICALS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; TROPANES;

EID: 34948837364     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000106476     Document Type: Article

References (23)

1. Byrum CE, Ahearn EP, Krishnan KR: A neuroanatomic model for depression. Prog Neuropsychopharmacol 1999;23:175-193.
2. Rogers MA, Bradshaw JL, Pantelis C, Phillips JG: Frontostriatal deficits in unipolar major depression. Brain Res Bull 1998;47:297-310.
3. Giros B, Jaber M, Jones SR, Wightman RM, Caron MG: Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. Nature 1996;379:606-612.
4. Jaber M, Jones S, Giros B, Caron MG: The dopamine transporter: a crucial component regulating dopamine transmission. Mov Disord 1997;12:629-633.
5. 99mTc]-TRODAT-1 to dopamine transporters in patients with Parkinson's disease and in healthy volunteers. J Nucl Med 2000;41:584-589.
6. Mozley LH, Gur RC, Mozley PD, Gur RE: Striatal dopamine transporters and cognitive functioning in healthy men and women. Am J Psychiatry 2001;158:1492-1499.
7. 99mTc]TRODAT-1 SPECT imaging. Am J Psychiatry 2003;160:1836-1841.
8. Yang YK, Yeh TL, Yoa WJ, Lee IH, Chen PS: Greater availability of dopamine transporter and no change in availability of D2/D3 receptor in major depression: a dual isotope SPECT study. Acad Conf Taiwanese Soc Psychiatry, Chung-Hua, Taiwan, November 2004.
9. Drevets WC, Price JL, Simpson JRJ, Todd RD, Reich T, Vannier M, Raichle ME: Subgenual prefrontal cortex abnormalities in mood disorders. Nature 1997;386:824-827.
10. Laasonen-Balk T, Kuikka J, Viinamaki H, Husso-Saastamoinen M, Lehtonen J, Tiihonen J: Striatal dopamine transporter density in major depression. Psychopharmacology (Berl) 1999;144:282-285.
11. Meyer JH, Kruger S, Wilson AA, et al: Lower dopamine transporter binding potential in striatum during depression. Neuroreport 2001;12:4121-4125.
12. Spitzer RL, Gibbon M, Williams JBW: Structured clinical interview for Axis I DSM-IV disorders - patient edition. Washington, American Psychiatric Press, 1994.
13. Williams JBW: A structured interview guide for the Hamilton Depression Rating Scale. Arch Gen Psychiatry 1988;45:742-747.
14. 123I]-2β-carbomethoxy-3β-(4-iodophenyl)tropane and single photon emission computed tomography. Biol Psychiatry 1998;44:1090-1098.
15. Bowden C, Cheetham SC, Lowther S, Katona CLE, Crompton MR, Horton RW: Reduced dopamine turnover in the basal ganglia of depressed suicides. Brain Res 1997;769:135-140.
16. Sachdev P, Aniss AM: Slowness of movement in melancholic depression. Biol Psychiatry 1994;35:253-262.
17. Caligiuri MP, Ellwanger J: Motor and cognitive aspects of motor retardation in depression. J Affect Disord 2000;57:83-93.
18. Cummings JL: Depression and Parkinson's disease: a review. Am J Psychiatry 1992;149:443-454.
19. McHugh PR: The neuropsychiatry of basal ganglia disorders: a triadic syndrome and its explanation. Neuropsychiatry Neuropsychol Behav Neurol 1989;2:239-247.
20. Anand A, Verhoeff P, Seneca N, Zoghbi SS, Seibyl JP, Charney DS, Innis RB: Brain SPECT imaging of amphetamine-induced dopamine release in euthymic bipolar disorder patients. Am J Psychiatry 2000;157:1108-1114.
21. Lammers CH, D'Souza U, Qin ZH, Lee SH, Yajima S, Mouradian MM: Regulation of striatal dopamine receptors by estrogen. Synapse 1999;34:222-227.
22. Gardiner SA, Morrison MF, Mozley PD, Mozley LH, Brensinger C, Bilker W, Newberg AB, Battistini M: Pilot study on the effect of estrogen replacement therapy on brain dopamine transporter availability in healthy, postmenopausal women. Am J Geriatr Psychiatry 2004;12:621-630.
23. Kugaya A, Seneca NM, Snyder PJ, et al: Changes in human in vivo serotonin and dopamine transporter availabilities during chronic antidepressant administration. Neuropsychopharmacology 2003;28:413-420.