AAV-PGIS gene transfer improves hypoxia-induced pulmonary hypertension in mice

Biochemical and Biophysical Research Communications

Volumn 363, Issue 3, 2007, Pages 656-661

  Kawakami, Takashi ^a   Kanazawa, Hideaki ^a   Satoh, Toru ^a   Ieda, Masaki ^a   Ieda, Yasuyo ^a   Kimura, Kensuke ^a   Mochizuki, Hideki ^b   Shimada, Takashi ^c   Yokoyama, Chieko ^d   Ogawa, Satoshi ^a   Tanabe, Tadashi ^a   Fukuda, Keiichi ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NIPPON MEDICAL SCHOOL   (Japan)

^d TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

AAV; Gene transfer; PGIS; Pulmonary hypertension

Indexed keywords

PARVOVIRUS VECTOR; PROSTACYCLIN SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE TRANSFER; HYPOXIA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; SURVIVAL; SYSTOLIC BLOOD PRESSURE; UPREGULATION;

6-KETOPROSTAGLANDIN F1 ALPHA; ANIMALS; ANOXIA; CYTOCHROME P-450 ENZYME SYSTEM; DEPENDOVIRUS; GENE EXPRESSION; GENE THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; INTRAMOLECULAR OXIDOREDUCTASES; LUNG; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; MUSCLE, SKELETAL; NIH 3T3 CELLS; ORGAN SIZE; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SURVIVAL ANALYSIS; TRANSFECTION;

ADENO-ASSOCIATED VIRUS; ANIMALIA; MUS;

EID: 34848927459     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.09.039     Document Type: Article

References (17)

1. Rich S., Dantzker D.R., Ayres S.M., Bergofsky E.H., Brundage B.H., Detre K.M., Fishman A.P., Goldring R.M., Groves B.M., Koerner S.K., et al. Ann. Int. Med. 107 (1987) 216-223
2. Rubin L.J. Primary pulmonary hypertension. N. Engl. J. Med. 336 (1997) 111-117
3. Miyata A., Hara S., Yokoyama C., Inoue H., Ullrich V., and Tanabe T. Molecular cloning and expression of human prostacyclin synthase. Biochem. Biophys. Res. Commun. 200 (1994) 1728-1734
4. Geraci M.W., Gao B., Shepherd D.C., Moore M.D., Westcott J.Y., Fagan K.A., Alger L.A., Tuder R.M., and Voelkel N.F. Pulmonary prostacyclin synthase overexpression in transgenic mice protects against development of hypoxic pulmonary hypertension. J. Clin. Invest. 103 (1999) 1509-1515
5. Nagaya N., Yokoyama C., Kyotani S., Shimonishi M., Morishita R., Uematsu M., Nishikimi T., Nakanishi N., Ogihara T., Yamagishi M., Miyatake K., Kaneda Y., and Tanabe T. Gene transfer of human prostacyclin synthase ameliorates monocrotaline-induced pulmonary hypertension in rats. Circulation 102 (2000) 2005-2010
6. Suhara H., Sawa Y., Fukushima N., Kagisaki K., Yokoyama C., Tanabe T., Ohtake S., and Matsuda H. Gene transfer of human prostacyclin synthase into the liver is effective for the treatment of pulmonary hypertension in rats. J. Thorac. Cardiovasc. Surg. 123 (2002) 855-861
7. Tahara N., Kai H., Niiyama H., Mori T., Sugi Y., Takayama N., Yasukawa H., Numaguchi Y., Matsui H., Okumura K., and Imaizumi T. Repeated gene transfer of naked prostacyclin synthase plasmid into skeletal muscles attenuates monocrotaline-induced pulmonary hypertension and prolongs survival in rats. Hum. Gene Ther. 15 (2004) 1270-1278
8. Yasuda T., Miyachi S., Kitagawa R., Wada K., Nihira T., Ren Y.R., Hirai Y., Ageyama N., Terao K., Shimada T., Takada M., Mizuno Y., and Mochizuki H. Neuronal specificity of alpha-synuclein toxicity and effect of Parkin co-expression in primates. Neuroscience 144 (2007) 743-753
9. Tonai T., Yokota K., Yano T., Hayashi Y., Yamamoto S., Yamashita K., and Miyazaki H. Enzyme immunoassay of 6-ketoprostaglandin F1 alpha in a solid phase. Biochim. Biophys. Acta 836 (1985) 335-343
10. Kataoka M., Nagaya N., Satoh T., Itoh T., Murakami S., Iwase T., Miyahara Y., Kyotani S., Sakai Y., Kangawa K., and Ogawa S. A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension. Am. J. Respir. Crit. Care Med. 172 (2005) 1575-1580
11. Zhao Y.D., Courtman D.W., Deng Y., Kugathasan L., Zhang Q., and Stewart D.J. Rescue of monocrotaline-induced pulmonary arterial hypertension using bone marrow-derived endothelial-like progenitor cells: efficacy of combined cell and eNOS gene therapy in established disease. Circ. Res. 96 (2005) 442-450
12. McMurtry M.S., Archer S.L., Altieri D.C., Bonnet S., Haromy A., Harry G., Bonnet S., Puttagunta L., and Michelakis E.D. Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J. Clin. Invest. 115 (2005) 1479-1491
13. Manno C.S., Pierce G.F., Arruda V.R., Glader B., Ragni M., Rasko J.J., Ozelo M.C., Hoots K., Blatt P., Konkle B., Dake M., Kaye R., Razavi M., Zajko A., Zehnder J., Rustagi P.K., Nakai H., Chew A., Leonard D., Wright J.F., Lessard R.R., Sommer J.M., Tigges M., Sabatino D., Luk A., Jiang H., Mingozzi F., Couto L., Ertl H.C., High K.A., and Kay M.A. Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response. Nat. Med. 12 (2006) 342-347
14. Wagner J.A., Reynolds T., Moran M.L., Moss R.B., Wine J.J., Flotte T.R., and Gardner P. Efficient and persistent gene transfer of AAV-CFTR in maxillary sinus. Lancet 351 (1998) 1702-1703
15. During M.J., Kaplitt M.G., Stern M.B., and Eidelberg D. Subthalamic GAD gene transfer in Parkinson disease patients who are candidates for deep brain stimulation. Hum. Gene Ther. 12 (2001) 1589-1591
16. Wang Z., Zhu T., Qiao C., Zhou L., Wang B., Zhang J., Chen C., Li J., and Xiao X. Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart. Nat. Biotechnol. 23 (2005) 321-328
17. Riviere C., Danos O., and Douar A.M. Long-term expression and repeated administration of AAV type 1, 2 and 5 vectors in skeletal muscle of immunocompetent adult mice. Gene Ther. 13 (2006) 1300-1308