Prevalence of erythrocyte haemoglobin H inclusions in unselected patients with clonal myeloid disorders

British Journal of Haematology

Volumn 139, Issue 3, 2007, Pages 439-442

  Steensma, David P ^a   Porcher, Julie C ^a   Hanson, Curtis A ^a   Lathrop, Cynthia L ^a   Hoyer, James D ^a   Lasho, Terra A ^a   Tefferi, Ayalew ^a   Higgs, Douglas R ^b  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

ATRX; Clonal evolution; Haemoglobin H; Myelodysplastic syndromes; Myeloproliferative disorders

Indexed keywords

HEMOGLOBIN H;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLONE; CONTROLLED STUDY; DEMOGRAPHY; ERYTHROCYTE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MYELOPROLIFERATIVE DISORDER; PHENOTYPE; PREVALENCE; PRIORITY JOURNAL;

ACUTE DISEASE; AGED; ALPHA-THALASSEMIA; ERYTHROCYTE INDICES; ERYTHROCYTES; FEMALE; HEMOGLOBIN H; HUMANS; LEUKEMIA, MYELOID; MALE; MIDDLE AGED; MYELODYSPLASTIC SYNDROMES; MYELOPROLIFERATIVE DISORDERS; PROSPECTIVE STUDIES;

EID: 34848920849     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2007.06831.x     Document Type: Article

References (12)

1. Ballas, S.K. Krasnow, S.H. (1981) Balanced globin synthesis in idiopathic myelofibrosis. Clinica Chimica Acta, 110, 255 259.
2. Brodsky, R.A., Vala, M.S., Barber, J.P., Medof, M.E. Jones, R.J. (1997) Resistance to apoptosis caused by PIG-A gene mutations in paroxysmal nocturnal hemoglobinuria. Proceedings of the National Academy of Sciences of the United States of America, 94, 8756 8760.
3. Gibbons, R.J., Pellagatti, A., Garrick, D., Wood, W.G., Malik, N., Ayyub, H., Langford, C., Boultwood, J., Wainscoat, J.S. Higgs, D.R. (2003) Identification of acquired somatic mutations in the gene encoding chromatin-remodeling factor ATRX in the alpha-thalassemia myelodysplasia syndrome (ATMDS). Nature Genetics, 34, 446 449.
4. Nelson, M.E., Thurmes, P.J., Hoyer, J.D. Steensma, D.P. (2005) A novel 5′ ATRX mutation with splicing consequences in acquired alpha thalassemia-myelodysplastic syndrome. Haematologica, 90, 1463 1470.
5. Sabath, D.E., Cross, S.T. Mamiya, L.Y. (2003) An improved method for detecting red cells with hemoglobin H inclusions that does not require glass capillary tubes. Clinical and Laboratory Haematology, 25, 87 91.
6. Siekmeier, R., Bierlich, A. Jaross, W. (2000) Determination of reticulocytes: three methods compared. Clinical Chemistry and Laboratory Medicine, 38, 245 249.
7. Steensma, D.P., Higgs, D.R., Fisher, C.A. Gibbons, R.J. (2004a) Acquired somatic ATRX mutations in myelodysplastic syndrome associated with alpha thalassemia (ATMDS) convey a more severe hematologic phenotype than germline ATRX mutations. Blood, 103, 2019 2026.
8. Steensma, D.P., Viprakasit, V., Hendrick, A., Goff, D.K., Leach, J., Gibbons, R.J. Higgs, D.R. (2004b) Deletion of the alpha-globin gene cluster as a cause of acquired alpha-thalassemia in myelodysplastic syndrome. Blood, 103, 1518 1520.
9. Steensma, D.P., Gibbons, R.J. Higgs, D.R. (2005) Acquired alpha-thalassemia in association with myelodysplastic syndrome and other hematologic malignancies. Blood, 105, 443 452.
10. Tefferi, A., Dingli, D., Li, C.Y. Mesa, R.A. (2006) Microcytosis in agnogenic myeloid metaplasia: prevalence and clinical correlates. Leukemia Research, 30, 677 680.
11. United Kingdom Cancer Cytogenetics Group (1992) Loss of the Y chromosome from normal and neoplastic bone marrows. United Kingdom Cancer Cytogenetics Group (UKCCG). Genes, Chromosomes and Cancer, 5, 83 88.
12. Veer, A., Kosciolek, B.A., Bauman, A.W. Rowley, P.T. (1979) Acquired hemoglobin H disease in idiopathic myelofibrosis. American Journal of Hematology, 6, 199 206.