Prevalence of abnormal liver-associated enzymes in cocaine experienced adults versus healthy volunteers during Phase 1 clinical trials

Contemporary Clinical Trials

Volumn 28, Issue 6, 2007, Pages 695-704

  Cantilena, Louis R ^a   Cherstniakova, Svetlana A ^a   Saviolakis, George ^a   Kahn, Roberta ^b   Elkashef, Ahmed ^b   Rose, Lauren ^a   Vocci, Frank ^b  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^b NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Cocaine; Inpatient trials; Liver associated enzymes; Phase 1

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ANTICOCAINE AGENT; ASPARTIC ACID; BILIRUBIN; COCAINE; CYTOCHROME P450; GAMMA GLUTAMYLTRANSFERASE; LIVER ENZYME; NARCOTIC ANTAGONIST; PLACEBO; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ADULT; ANALYSIS OF VARIANCE; ARTICLE; BODY MASS; CLINICAL RESEARCH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DOUBLE BLIND PROCEDURE; DRUG ABUSE; DRUG INDUCED DISEASE; FEMALE; HOSPITAL PATIENT; HUMAN; HUMAN EXPERIMENT; LIVER INJURY; LIVER TOXICITY; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; NUTRITION; PHASE 1 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL; SCREENING; URINALYSIS; XENOBIOTIC METABOLISM;

ADOLESCENT; ADULT; CLINICAL TRIALS, PHASE I AS TOPIC; COCAINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYMES; FEMALE; HUMANS; INPATIENTS; LIVER; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; UNITED STATES;

EID: 34848907808     PISSN: 15517144     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cct.2007.03.005     Document Type: Article

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