Changes in mouse circulating leukocyte numbers in C57BL/6 mice immunosuppressed with dexamethasone for Cryptosporidium parvum oocyst production

Veterinary Parasitology

Volumn 149, Issue 3-4, 2007, Pages 147-157

  Miller, Thomas A ^a   Schaefer III, Frank W ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Cryptosporidium parvum; Dexamethasone; Immunosuppression; Leukocytes; Methylprednisolone acetate; Spleen; T lymphocytes; Thymus

Indexed keywords

CD3 ANTIBODY; DEXAMETHASONE; METHYLPREDNISOLONE ACETATE; TETRACYCLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CRYPTOSPORIDIUM PARVUM; FEMALE; IMMUNE DEFICIENCY; IMMUNOCOMPETENCE; LEUKOCYTE; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; OOCYST; SINGLE DRUG DOSE; SPLEEN; T LYMPHOCYTE; THYMUS;

ANIMALS; ANTIGENS, CD3; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CRYPTOSPORIDIUM PARVUM; DEXAMETHASONE; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEMATOCRIT; IMMUNOCOMPROMISED HOST; IMMUNOSUPPRESSIVE AGENTS; LEUKOCYTE COUNT; METHYLPREDNISOLONE; MICE; MICE, INBRED C57BL; NEUTROPHILS; OOCYSTS; SPLEEN; THYMUS GLAND;

CRYPTOSPORIDIUM PARVUM; MUS;

EID: 34848907467     PISSN: 03044017     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetpar.2007.08.017     Document Type: Article

References (31)

1. Arrowood M.J., and Donaldson K. Improved purification methods for calf-derived Cryptosporidium parvum oocysts using discontinuous sucrose and cesium chloride gradients. J. Eukaryot. Microbiol. 43 (1996) 89S
2. Ash L.R., and Orihel T.C. Parasites: A Guide to Laboratory Procedures and Identification (1987), American Society of Clinical Pathologists Press, Chicago pp. 31-33
3. Bozić F., Marinculić A., and Duraković E. Analysis of intestinal intraepithelial lymphocyte populations in experimental Trichinella spiralis infection of mice. Folia Parasitol. 47 (2000) 55-59
4. Brunetti M., Mascetra N., Martelli N., Ranelletti F.O., Musiani P., and Ajello F.B. Synergistic inhibitory activities of interlukin-10 and dexamethasone on human CD4+ T cells. Transplantation 74 8 (2002) 1152-1158
5. Chappell C.L., and Okhuysen P.C. Cryptosporidiosis in healthy adult volunteers. In: Smith M., and Thompson R.C. (Eds). Cryptosporidium: The Analytical Challenge (2001), The Royal Society of Chemistry, Cambridge, UK 62-72
6. Cicmanec J.L., and Reasoner D.J. Enhanced production of Cryptosporidium parvum oocysts in immunosuppressed mice. In: Fricker C.R., Clancy J.L., and Rochelle P.A. (Eds). Proceedings of the International Symposium on Waterborne Cryptosporidium (1997), American Water works Association, Denver 127-131
7. Cifone M.G., Migliorati G., Parroni R., Marchetti C., Millimaqqi D., Santoni A., and Riccardi C. Dexamethasone-induced thymocyte apoptosis: apoptotic signal involves the sequential activation of phosphoinositide-specific phospholipase C, acidic sphingomyelinase, and caspases. Blood 93 (1999) 2282-2296
8. Crabb J.H. Antibody-based immunotherapy of cryptosporidiosis. Adv. Parasitol. 40 (1998) 121-149
9. Culshaw R.J., Bancroft G.J., and McDonald V. Gut intraepithelial lymphocytes induce immunity against Cryptosporidium infection through a mechanism involving gamma interferon production. Infect. Immun. 65 (1997) 3074-3079
10. Current W.L., and Blagburn B.L. Cryptosporidium: infections in man and domesticated animals. In: Long P.L. (Ed). Coccidiosis of Man and Domestic Animals (1990), CRC Press, Boca Raton, FL 155-185
11. Current W.L., and Garcia L.S. Cryptosporidiosis. Clin. Microbiol. Rev. 4 (1991) 325-358
12. Enriquez F.J., and Sterling C.R. Cryptosporidium infections in inbred strains of mice. J. Protozool. 38 (1991) 100S-102S
13. Fauci A. Principles of therapeutics. In: Wyngaarden J.B., and Smith Jr. L.H. (Eds). Cecil's Textbook of Medicine (1982), W.B. Saunders, Philadelphia 86-91
14. Fayer R., and Ungar B.L. Cryptosporidium spp. and cryptosporidiosis. Microbiol. Rev. 50 (1986) 458-483
15. Gatei W., Ashford R.W., Beeching N.J., Kamwati S.K., Greensill J., and Hart C.A. Cryptosporidium muris infection in an HIV-infected adult, Kenya. Emerg. Infect. Dis. 8 (2002) 204-206
16. Goodgame R.W., Genta R.M., White A.C., and Chappell C.L. Intensity of infection in AIDS-associated cryptosporidiosis. J. Infect. Dis. 167 (1993) 704-709
17. Goodman L.S., and Gilman A. The Pharmacological Basis of Therapeutics (1970), The Macmillan Co., New York, NY p. 1259
18. Guyton A.C., and Hall J.E. The adrenocortical hormones. In: Guyton A.C., and Hall J.E. (Eds). Textbook of Medical Physiology (2000), W.B. Saunders Co., Philadelphia, PA 869-883
19. Hinrichs C.S., Palmer D.C., Rosenberg S.A., and Restifo N.P. Glucorticoids do not inhibit antitumor activity of activated CD8+ T cells. J. Immunother. 28 6 (2005) 517-524
20. Mac Kenzie W.R., Hoxie N.J., Proctor M.E., Gradus M.S., Blair K.A., Peterson D.E., Kazmierczak J.J., Addiss D.G., Fox K.R., Rose J.B., and Davis J.P. A massive outbreak in Milwaukee of Cryptosporidium infection transmitted through the public water supply. N. Engl. J. Med. 331 (1994) 161-167
21. McDonald V. Gut intraepithelial lymphocytes and immunity to Coccidia. Parasitol. Today 15 (1999) 483-487
22. McDonald V., Deer R., Uni S., Iseki M., and Bancroft G.J. Immune responses to Cryptosporidium muris and Cryptosporidium parvum in adult immunocompetent or immunocompromised (nude and SCID) mice. Infect. Immun. 60 (1992) 3325-3331
23. McDonald V., Robinson H.A., Kelly J.P., and Bancroft G.J. Cryptosporidium muris in adult mice: adoptive transfer of immunity and protective roles of CD4 versus CD8 cells. Infect. Immun. 62 (1994) 2289-2294
24. Miller T.A., and Schaefer III F.W. Characterization of a single dose methylprednisolone acetate immune suppression model using Cryptosporidium muris and Cryptosporidium parvum. Vet. Parasitol. 141 1-2 (2006) 66-83
25. Miller T.A., Ware M.W., Wymer L.J., and Schaefer III F.W. Chemically and genetically immunocompromised mice are not more susceptible than immunocompetent mice to infection with Cryptosporidium muris. Vet. Parasitol. 143 (2007) 99-105
26. Rasmussen K.R., and Healey M.C. Experimental Cryptosporidium parvum infections in immunosuppressed adult mice. Infect. Immun. 60 (1992) 1648-1652
27. Schalm O.W. Veterinary Hematology (1970), Lea and Febiger, Philadelphia, PA pp. 440-447
28. Thompson E.B. Mechanisms of T-cell apoptosis induced by glucocorticoids. Trends Endocrinol. Metab. 10 (1999) 353-358
29. Ungar B.L.P., Burris J.A., Quinn C.A., and Finkelman F.D. New mouse models for chronic Cryptosporidium infection in immunodeficient hosts. Infect. Immun. 58 (1990) 961-969
30. Xiao L., Morgan U.M., Fayer R., Thompson R.C.A., and Lal A.A. Cryptosporidium systematics and implications for public health. Parasitol. Today 16 (2000) 287-292
31. Yang S., and Healey M.C. The immunosuppressive effects of dexamethasone administered in drinking water to C57BL/6N mice infected with Cryptosporidium parvum. J. Parasitol. 79 (1993) 626-630