Enteral resveratrol supplementation attenuates intestinal epithelial inducible nitric oxide synthase activity and mucosal damage in experimental necrotizing enterocolitis

Journal of Pediatric Surgery

Volumn 42, Issue 10, 2007, Pages 1687-1694

  Ergün, Orkan ^a   Ergün, Güliz ^a   Öktem, Gülperi ^a   Selvi, Nur ^a   Doǧan, Hakan ^a   Tunçyürek, Müge ^a   Saydam, Güray ^a   Erdener, Ata ^a  

^a EGE UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Inducible nitric oxide synthase; Necrotizing enterocolitis; Resveratrol

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; NITRATE; NITRITE; PHYTOALEXIN; POLYPHENOL; RADICAL; RESVERATROL; SCAVENGER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BACTERIAL TRANSLOCATION; BREAST FEEDING; BRUSH BORDER; CELL CYCLE; CELL HYPOXIA; CELL VACUOLE; CONTROLLED STUDY; ENTERIC FEEDING; ENZYME ACTIVITY; ENZYME RELEASE; HISTOPATHOLOGY; ILEUM; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTESTINE CELL; INTESTINE EPITHELIUM; INTESTINE MUCOSA; MOLECULAR WEIGHT; NECROTIZING ENTEROCOLITIS; NEWBORN; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; SEPSIS; WESTERN BLOTTING;

ADMINISTRATION, ORAL; ANIMALS; ANIMALS, NEWBORN; ANTIOXIDANTS; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ENTEROCOLITIS, NECROTIZING; FEMALE; ILEUM; INTESTINAL MUCOSA; MALE; MICROVILLI; NITRATES; NITRIC OXIDE SYNTHASE TYPE II; NITRITES; PREGNANCY; RANDOM ALLOCATION; RATS; RATS, WISTAR; STILBENES;

EID: 34848902887     PISSN: 00223468     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpedsurg.2007.05.024     Document Type: Article

References (22)

1. Ford H.R., Sorrells D.L., and Knisely A.S. Inflammatory cytokines, nitric oxide and necrotizing enterocolitis. Pediatr Surg 5 3 (1995) 155-159
2. Kliegman R.M. Neonatal necrotizing enterocolitis: bridging the basic science with the clinical disease. J Pediatr 117 (1990) 833
3. Ford H.R., Watkins S., Reblock K., et al. The role of inflammatory cytokines and nitric oxide in the pathogenesis of necrotizing enterocolitis. J Pediatr Surg 32 (1997) 275-282
4. Chung D.H., Ethridge R.T., Kim S., et al. Molecular mechanisms contributing to necrotizing enterocolitis. Ann Surg 233 6 (2001) 835-842
5. Martin A.R., Villegas I., Casa C.L., et al. Resveratrol, a polyphenol found in grapes, suppresses oxidative damage and stimulates apoptosis during early colonic inflammation in rats. Biochem Phamacol 67 (2004) 1399-1410
6. Feng Y.H., Zhou W.L., Wu Q.L., et al. Low dose resveratrol enhanced immune response of mice. Acta Pharmacol Sin 23 10 (2002) 893-897
7. Fremont L. Biological effects of resveratrol. Life Sci 66 (2000) 663-673
8. Belguendouz L., Fremont L., and Gozzelino M.T. Interaction of trans-resveratrol with plasma proteins. Biochem Pharmacol 55 (1998) 811-816
9. Tsai S.H., Lin-Shaiu S.Y., and Lin J.K. Suppression of nitric oxide synthase and downregulation of the activation of NFkappaB in macrophages by resveratrol. Br J Pharmacol 126 (1999) 673-680
10. Subbaramaiah K., Chung W.J., Michaluart P., et al. Resveratrol inhibits cyclooxygenase-2 transcription and activity in phorbol ester-treated human mammary epithelial cells. JBC 273 34 (1998) 21875-21882
11. Çetin S., Dunkelberger J., Li J., et al. Endotoxin differentially modulates the basolateral and apical sodium/proton exchangers (NHE) in enterocytes. Surgery 136 (2004) 375-383
12. Kelly N., Friend K., Boyle P., et al. The role of glutathione antioxidant system in gut barrier failure in a rodent model of experimental necrotizing enterocolitis. Surgery 136 (2004) 557-566
13. Nadler E., and Ford H.R. Regulation of bacterial translocation by nitric oxide. Pediatr Surg Int 16 (2000) 165-168
14. Nadler E., Upperman J., and Ford H.R. Controversies in the management of necrotizing enterocolitis. Surg Infect 2 (2001) 113-120
15. Caplan M.S., and Hseueh W. Necrotizing enterocolitis: the role of platelet activating factor, endotoxin and tumor necrosis factor. J Pediatr Surg 117 (1990) S47-S51
16. Nathan C., and Xie Q. Nitric oxide synthases: roles, tolls and controls. Cell 78 (1994) 915
17. Potoka D.A., Nadler E.P., Upperman J.S., et al. Role of nitric oxide and peroxinitrite in gut barrier failure. World J Surg 26 (2002) 806-811
18. Zamora R., Vodovotz Y., and Biliar T.R. Inducible nitric oxide synthase and inflammatory diseases. Mol Med 6 5 (2000) 347-373
19. Nadler E.P., Dickinson E.C., Beer-Stolz D., et al. Scavenging nitric oxide reduces hepatocellular injury after endotoxin challenge. Am J Physiol Gastrointest Liver Physiol 281 (2001) G173-G181
20. Zuckerbraun B.S., Otterbein L.E., Boyle P., et al. Carbon monoxide protects against the development of experimental necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 289 3 (2005) G607-G613
21. Barlow B., Santulli T.V., Heird W.C., et al. An experimental study of acute neonatal enterocolitis-The importance of breast milk. J Pediatr Surg 9 (1974) 587-595
22. Zamora R., Bryan N.S., Boyle P., et al. Nitrosative stress in an animal model of necrotizing enterocolitis. Free Radic Biol Med 39 11 (2005) 1428-1437