메뉴 건너뛰기




Volumn 5, Issue 7, 2007, Pages 544-552

Use of hypomethylating agents in myelodysplastic syndromes

Author keywords

5 aza 2' deoxycytidine; 5 azacytidine; DNA methylation; Myelodysplastic syndromes

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; 5,6 DIHYDROAZACITIDINE; ANTINEOPLASTIC AGENT; AZACITIDINE; DNA HYPOMETHYLATING AGENT; EPIGALLOCATECHIN GALLATE; FAZARABINE; FLUCYTOSINE DEOXYRIBOSIDE; GREEN TEA EXTRACT; HISTONE DEACETYLASE INHIBITOR; HYDRALAZINE; LBH 589; MG 98; MGCD 0103; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; NUCLEOSIDE ANALOG; POLYPHENOL; PROCAINAMIDE; RETINOIC ACID; TRICHOSTATIN A; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT; ZEBULARINE;

EID: 34848895438     PISSN: 15430790     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (6)

References (78)
  • 1
    • 0037108309 scopus 로고    scopus 로고
    • Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment
    • Daskalakis M, Nguyen TT, Nguyen C, et al. Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2′-deoxycytidine (decitabine) treatment. Blood. 2002;100:2957-2964.
    • (2002) Blood , vol.100 , pp. 2957-2964
    • Daskalakis, M.1    Nguyen, T.T.2    Nguyen, C.3
  • 2
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogs and DNA methylation
    • Jones PA, Taylor SM. Cellular differentiation, cytidine analogs and DNA methylation. Cell. 1980;20:85-93.
    • (1980) Cell , vol.20 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 3
    • 0030612423 scopus 로고    scopus 로고
    • Hypermethylation of the p15INK4B gene in myelodysplastic syndromes
    • Uchida T. Kinoshita T, Nagai H, et al. Hypermethylation of the p15INK4B gene in myelodysplastic syndromes. Blood. 1997;90:1403-1409.
    • (1997) Blood , vol.90 , pp. 1403-1409
    • Uchida, T.1    Kinoshita, T.2    Nagai, H.3
  • 4
    • 33744918070 scopus 로고    scopus 로고
    • DNA methylation changes after 5-aza-2′-deoxycytidine therapy in patients with leukemia
    • Yang AS, Doshi KD, Choi SW, et al. DNA methylation changes after 5-aza-2′-deoxycytidine therapy in patients with leukemia. Cancer Res. 2006;66: 5495-5503.
    • (2006) Cancer Res , vol.66 , pp. 5495-5503
    • Yang, A.S.1    Doshi, K.D.2    Choi, S.W.3
  • 5
    • 0021668041 scopus 로고
    • 1-beta-D-arabinosyl-5-azacytosine. Cytocidal activity and effects on the synthesis and methylation of DNA in human colon carcinoma cells
    • Glazer RI, Knode MC. 1-beta-D-arabinosyl-5-azacytosine. Cytocidal activity and effects on the synthesis and methylation of DNA in human colon carcinoma cells. Mol Pharmacol. 1984;26:381-387.
    • (1984) Mol Pharmacol , vol.26 , pp. 381-387
    • Glazer, R.I.1    Knode, M.C.2
  • 6
    • 0037420191 scopus 로고    scopus 로고
    • Inhibition of DNA methylation and reactivation of silenced genes by zebularine
    • Cheng JC, Matsen CB, Gonzales FA, et al. Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J Natl Cancer Inst. 2003;95:399-409.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 399-409
    • Cheng, J.C.1    Matsen, C.B.2    Gonzales, F.A.3
  • 7
    • 24544479951 scopus 로고    scopus 로고
    • Antitumor activity of MG98, an antisense oligodeoxynucleotide targeting DNA methyltransferase 1 (DNMT1) [abstract]
    • Beaulieu N, Fournel M, MacLeod AR. Antitumor activity of MG98, an antisense oligodeoxynucleotide targeting DNA methyltransferase 1 (DNMT1) [abstract]. Clin Cancer Res. 2001;7:3800S.
    • (2001) Clin Cancer Res , vol.7
    • Beaulieu, N.1    Fournel, M.2    MacLeod, A.R.3
  • 8
    • 22244435605 scopus 로고    scopus 로고
    • Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases
    • Brueckner B, Garcia Boy R, Siedlecki P. et al. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Res. 2005;65:6305-6311.
    • (2005) Cancer Res , vol.65 , pp. 6305-6311
    • Brueckner, B.1    Garcia Boy, R.2    Siedlecki, P.3
  • 9
    • 0345275879 scopus 로고    scopus 로고
    • Tea polyphenol (-)-epigallocatechin-3-gallate inhibits dna methyltransferase and reactivates methylation-silenced genes in cancer cell lines
    • Fang MZ, Wang Y, Ai N, et al. Tea polyphenol (-)-epigallocatechin-3-gallate inhibits dna methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res. 2003;63:7563-7570.
    • (2003) Cancer Res , vol.63 , pp. 7563-7570
    • Fang, M.Z.1    Wang, Y.2    Ai, N.3
  • 10
    • 10744225448 scopus 로고    scopus 로고
    • Reactivation of tumor suppressor genes by die cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy
    • Segura-Pacheco B, Trejo-Becerril C, Perez-Cardenas E, et al. Reactivation of tumor suppressor genes by die cardiovascular drugs hydralazine and procainamide and their potential use in cancer therapy. Clin Cancer Res. 2003;9:1596-1603.
    • (2003) Clin Cancer Res , vol.9 , pp. 1596-1603
    • Segura-Pacheco, B.1    Trejo-Becerril, C.2    Perez-Cardenas, E.3
  • 11
    • 28844497663 scopus 로고    scopus 로고
    • Procainamide is a specific inhibitor of DNA methyltransferase 1
    • Lee BH, Yegnasubramanian S, Lin X, Nelson WG. Procainamide is a specific inhibitor of DNA methyltransferase 1. J Biol Chem. 2005;280:40749-40756.
    • (2005) J Biol Chem , vol.280 , pp. 40749-40756
    • Lee, B.H.1    Yegnasubramanian, S.2    Lin, X.3    Nelson, W.G.4
  • 12
    • 0038627550 scopus 로고    scopus 로고
    • Psammaplins from the sponge Pseudoceratina purpurea: Inhibition of both histone deacetylase and DNA methyltransferase
    • Pina IC, Gautschi JT, Wang GY, et al. Psammaplins from the sponge Pseudoceratina purpurea: inhibition of both histone deacetylase and DNA methyltransferase. J Org Chem. 2003;68:3866-3873.
    • (2003) J Org Chem , vol.68 , pp. 3866-3873
    • Pina, I.C.1    Gautschi, J.T.2    Wang, G.Y.3
  • 13
    • 0345357773 scopus 로고    scopus 로고
    • Gene silencing in cancer in association with promoter hypermethylation
    • Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003;349:2042-2054.
    • (2003) N Engl J Med , vol.349 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 14
    • 0032731581 scopus 로고    scopus 로고
    • Hypermethylation of tumor suppressor genes in cancer
    • Herman JG. Hypermethylation of tumor suppressor genes in cancer. Semin Cancer Biol. 1999;9:359-367.
    • (1999) Semin Cancer Biol , vol.9 , pp. 359-367
    • Herman, J.G.1
  • 15
    • 0029587022 scopus 로고
    • Gametic imprinting in mammals
    • Barlow DP. Gametic imprinting in mammals. Science. 1995;270:1610-1613.
    • (1995) Science , vol.270 , pp. 1610-1613
    • Barlow, D.P.1
  • 16
    • 0031811256 scopus 로고    scopus 로고
    • Regulation of X-chromosome iinactivation in development in mice and humans
    • Goto T, Monk M. Regulation of X-chromosome iinactivation in development in mice and humans. Microbiol Mol Biol Rev. 1998;62:362-378.
    • (1998) Microbiol Mol Biol Rev , vol.62 , pp. 362-378
    • Goto, T.1    Monk, M.2
  • 17
    • 0035799382 scopus 로고    scopus 로고
    • Changes in DNA methylation in neoplasia: Pathophysiology and therapeutic implications
    • Santini V, Kantarjian HM, Issa JP. Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann Intern Med. 2001; 134: 573-586.
    • (2001) Ann Intern Med , vol.134 , pp. 573-586
    • Santini, V.1    Kantarjian, H.M.2    Issa, J.P.3
  • 18
    • 23844557794 scopus 로고    scopus 로고
    • Characterization of DNA demethylation effects induced by 5-Aza-2′-deoxycytidine in patients with myelodysplastic syndrome
    • Mund C, Hackanson B, Stresemann C, Lubbert M, Lyko F. Characterization of DNA demethylation effects induced by 5-Aza-2′-deoxycytidine in patients with myelodysplastic syndrome. Cancer Res. 2005;65:7086-7090.
    • (2005) Cancer Res , vol.65 , pp. 7086-7090
    • Mund, C.1    Hackanson, B.2    Stresemann, C.3    Lubbert, M.4    Lyko, F.5
  • 19
    • 33644990380 scopus 로고    scopus 로고
    • Angiostatic activity of DNA methyltransferase inhibitors
    • Hellebrekers DM, Jair KW Vice E, et al. Angiostatic activity of DNA methyltransferase inhibitors. Mol Cancer Ther 2006;5:467-475.
    • (2006) Mol Cancer Ther , vol.5 , pp. 467-475
    • Hellebrekers, D.M.1    Jair, K.W.2    Vice, E.3
  • 20
    • 14844313747 scopus 로고    scopus 로고
    • 5-Aza-2′-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia
    • Schmelz K, Wagner M, Dorken B, Tamm I. 5-Aza-2′-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia. Int J Cancer. 2005; 114:683-695.
    • (2005) Int J Cancer , vol.114 , pp. 683-695
    • Schmelz, K.1    Wagner, M.2    Dorken, B.3    Tamm, I.4
  • 21
    • 0242539831 scopus 로고    scopus 로고
    • Epigenetic targets for immune intervention in human malignancies
    • Maio M, Coral S, Fratta E, Altomonte M, Sigalotti L. Epigenetic targets for immune intervention in human malignancies. Oncogene. 2003;22:6484-6488.
    • (2003) Oncogene , vol.22 , pp. 6484-6488
    • Maio, M.1    Coral, S.2    Fratta, E.3    Altomonte, M.4    Sigalotti, L.5
  • 22
    • 33748046812 scopus 로고    scopus 로고
    • Phase I trial of sequential low-dose 5-aza-2′-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma
    • Gollob JA, Sciambi CJ, Peterson BL et al. Phase I trial of sequential low-dose 5-aza-2′-deoxycytidine plus high-dose intravenous bolus interleukin-2 in patients with melanoma or renal cell carcinoma. Clin Cancer Res. 2006;12:4619-4627.
    • (2006) Clin Cancer Res , vol.12 , pp. 4619-4627
    • Gollob, J.A.1    Sciambi, C.J.2    Peterson, B.L.3
  • 23
    • 0013773866 scopus 로고
    • 5-Azacytidine, a new, highly effective cancerostatic
    • Sorm F, Piskala A, Cihak A, Vesely J. 5-Azacytidine, a new, highly effective cancerostatic. Experientia. 1964;20:202-203.
    • (1964) Experientia , vol.20 , pp. 202-203
    • Sorm, F.1    Piskala, A.2    Cihak, A.3    Vesely, J.4
  • 25
    • 0001583359 scopus 로고
    • The activity of a new antimetabolite, 5-azacytidine, against lymphoid leukemia in AK mice
    • Sorm F, Vesely J. The activity of a new antimetabolite, 5-azacytidine, against lymphoid leukemia in AK mice. Neoplasma. 1964; 11:123-130.
    • (1964) Neoplasma , vol.11 , pp. 123-130
    • Sorm, F.1    Vesely, J.2
  • 26
    • 0014241870 scopus 로고
    • Effect of 5-aza-2′-deoxycytidine against leukemic and hemopoietic tissues in AKR mice
    • Sorm F, Vesely J. Effect of 5-aza-2′-deoxycytidine against leukemic and hemopoietic tissues in AKR mice. Neoplasma. 1968;15:339-343.
    • (1968) Neoplasma , vol.15 , pp. 339-343
    • Sorm, F.1    Vesely, J.2
  • 27
    • 21844466446 scopus 로고    scopus 로고
    • Pharmacology of 5-Aza-2′-deoxycytidine (decitabine)
    • Momparler RL. Pharmacology of 5-Aza-2′-deoxycytidine (decitabine). Semin Hematol. 2005;42:S9-16.
    • (2005) Semin Hematol , vol.42
    • Momparler, R.L.1
  • 28
    • 0021125089 scopus 로고
    • Kinetic interaction of 5-AZA-2′-deoxycytidine-5′-monophosphate and its 5′-triphosphate with deoxycytidylate deaminase
    • Momparler RL, Rossi M, Bouchard J, et al. Kinetic interaction of 5-AZA-2′-deoxycytidine-5′-monophosphate and its 5′-triphosphate with deoxycytidylate deaminase. Mol Pharmacol. 1984;25:436-440.
    • (1984) Mol Pharmacol , vol.25 , pp. 436-440
    • Momparler, R.L.1    Rossi, M.2    Bouchard, J.3
  • 29
    • 0028151343 scopus 로고
    • Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
    • Juttermann R, Li E, Jaenisch R. Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci USA. 1994;91: 11797-11801.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11797-11801
    • Juttermann, R.1    Li, E.2    Jaenisch, R.3
  • 30
    • 0018581647 scopus 로고
    • Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine
    • Taylor SM, Jones PA. Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine. Cell. 1979;17:771-779.
    • (1979) Cell , vol.17 , pp. 771-779
    • Taylor, S.M.1    Jones, P.A.2
  • 32
    • 0344990164 scopus 로고    scopus 로고
    • Phase I trial of continuous infusion 5-aza-2′-deoxycytidine
    • Aparicio, A, Eads CA, Leong LA, et al. Phase I trial of continuous infusion 5-aza-2′-deoxycytidine. Cancer Chemother Pharmacol. 2003;51:231-239.
    • (2003) Cancer Chemother Pharmacol , vol.51 , pp. 231-239
    • Aparicio, A.1    Eads, C.A.2    Leong, L.A.3
  • 33
    • 33846058851 scopus 로고    scopus 로고
    • A phase I pharmacokinetic trial of decitabine administered as a 3-hour infusion to patients with acute myelogenous leukemia (AML) or myclodysplastic syndrome (MDS)
    • Cashen A, Shah A, Helget A, et al. A phase I pharmacokinetic trial of decitabine administered as a 3-hour infusion to patients with acute myelogenous leukemia (AML) or myclodysplastic syndrome (MDS). ASH Annual Meeting Abstracts. 2005;106:1854.
    • (2005) ASH Annual Meeting Abstracts , vol.106 , pp. 1854
    • Cashen, A.1    Shah, A.2    Helget, A.3
  • 34
    • 0019857236 scopus 로고
    • Phase I study on 5-aza-2′-deoxycytidine in children with acute leukemia
    • Rivard GE, Momparler RL, Demers J, et al. Phase I study on 5-aza-2′-deoxycytidine in children with acute leukemia. Leuk Res. 1981;5:453-462.
    • (1981) Leuk Res , vol.5 , pp. 453-462
    • Rivard, G.E.1    Momparler, R.L.2    Demers, J.3
  • 35
    • 0022501789 scopus 로고
    • Phase I and pharmacokinetic study of 5-aza-2′-deoxycytidine (NSC 127716) in cancer patients
    • van Groeningen CJ, Leyva A, O'Brien AM, Gail HE, Pinedo HM. Phase I and pharmacokinetic study of 5-aza-2′-deoxycytidine (NSC 127716) in cancer patients. Cancer Res. 1986;46:4831-4836.
    • (1986) Cancer Res , vol.46 , pp. 4831-4836
    • van Groeningen, C.J.1    Leyva, A.2    O'Brien, A.M.3    Gail, H.E.4    Pinedo, H.M.5
  • 36
    • 0020629104 scopus 로고
    • Kinetics of deamination of 5-aza-2′-deoxycytidine and cytosine arabinoside by human liver cytidine deaminase and its inhibition by 3-deazauridine, thymidine or uracil arabinoside
    • Chabot GG, Bouchard J, Momparler RL. Kinetics of deamination of 5-aza-2′-deoxycytidine and cytosine arabinoside by human liver cytidine deaminase and its inhibition by 3-deazauridine, thymidine or uracil arabinoside. Biochem Pharmacol. 1983;32:1327-1328.
    • (1983) Biochem Pharmacol , vol.32 , pp. 1327-1328
    • Chabot, G.G.1    Bouchard, J.2    Momparler, R.L.3
  • 37
    • 0020679784 scopus 로고
    • Plasma and cerebrospinal fluid pharmacokinetics of 5-Aza-2′-deoxycytidine in rabbits and dogs
    • Chabot GG, Rivard GE, Momparler RL. Plasma and cerebrospinal fluid pharmacokinetics of 5-Aza-2′-deoxycytidine in rabbits and dogs. Cancer Res. 1983;43:592-597.
    • (1983) Cancer Res , vol.43 , pp. 592-597
    • Chabot, G.G.1    Rivard, G.E.2    Momparler, R.L.3
  • 38
    • 17644404081 scopus 로고    scopus 로고
    • Bioavailability of azacitidine subcutaneous versus intravenous in patients with the myelodysplastic syndromes
    • Marcucci G, Silverman L, Eller M, Lintz L, Beach CL. Bioavailability of azacitidine subcutaneous versus intravenous in patients with the myelodysplastic syndromes. J Clin Pbarmacol. 2005;45:597-602.
    • (2005) J Clin Pbarmacol , vol.45 , pp. 597-602
    • Marcucci, G.1    Silverman, L.2    Eller, M.3    Lintz, L.4    Beach, C.L.5
  • 39
    • 0017253916 scopus 로고
    • The disposition and pharmacokinetics in humans of 5-azacytidine administered intravenously as a bolus or by continuous infusion
    • Israili ZH, Vogler WR, Mingioli ES, et al. The disposition and pharmacokinetics in humans of 5-azacytidine administered intravenously as a bolus or by continuous infusion. Cancer Res. 1976;36:1453-1461.
    • (1976) Cancer Res , vol.36 , pp. 1453-1461
    • Israili, Z.H.1    Vogler, W.R.2    Mingioli, E.S.3
  • 40
    • 0036786901 scopus 로고    scopus 로고
    • The World Health Organization (WHO) classification of the myeloid neoplasms
    • Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 2002; 100:2292-2302.
    • (2002) Blood , vol.100 , pp. 2292-2302
    • Vardiman, J.W.1    Harris, N.L.2    Brunning, R.D.3
  • 41
    • 0034554786 scopus 로고    scopus 로고
    • Report of an international working group to standardize response criteria for myelodysplastic syndromes
    • Cheson BD, Bennett JM, Kantarjian H, et al. Report of an international working group to standardize response criteria for myelodysplastic syndromes. Blood. 2000;96:3671-3674.
    • (2000) Blood , vol.96 , pp. 3671-3674
    • Cheson, B.D.1    Bennett, J.M.2    Kantarjian, H.3
  • 42
    • 33748474416 scopus 로고    scopus 로고
    • Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: Studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B
    • Silverman LR, McKenzie DR, Peterson BL, et al. Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B. J Clin Oncol. 2006;24: 3895-3903.
    • (2006) J Clin Oncol , vol.24 , pp. 3895-3903
    • Silverman, L.R.1    McKenzie, D.R.2    Peterson, B.L.3
  • 43
    • 0037093195 scopus 로고    scopus 로고
    • Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: A study of the cancer and leukemia group B
    • Silverman LR, Demakos EP, Peterson BL, et al. Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. J Clin Oncol. 2002;20:2429-2440.
    • (2002) J Clin Oncol , vol.20 , pp. 2429-2440
    • Silverman, L.R.1    Demakos, E.P.2    Peterson, B.L.3
  • 44
    • 34247338444 scopus 로고    scopus 로고
    • Response rates using International Working Group (IWG) criteria in patients with myelodysplastic syndromes (MDS) treated with azacitidine
    • Silverman LR, McKenzie DR, Peterson BL, et al. Response rates using International Working Group (IWG) criteria in patients with myelodysplastic syndromes (MDS) treated with azacitidine. ASH Annual Meeting Abstracts. 2005;106:2526.
    • (2005) ASH Annual Meeting Abstracts , vol.106 , pp. 2526
    • Silverman, L.R.1    McKenzie, D.R.2    Peterson, B.L.3
  • 45
    • 0037092962 scopus 로고    scopus 로고
    • Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: A Cancer and Leukemia Group B study
    • Kornblith AB, Herndon JE, Silverman LR, et al. Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study. J Clin Oncol. 2002;20:2441-2452.
    • (2002) J Clin Oncol , vol.20 , pp. 2441-2452
    • Kornblith, A.B.1    Herndon, J.E.2    Silverman, L.R.3
  • 46
    • 33846068651 scopus 로고    scopus 로고
    • Analysis of survival, AML transformation, and transfusion independence in patients with high-risk myelodysplastic syndromes (MDS) receiving azacitidine determined using a prognostic model
    • Silverman LR, McKenzie DR, Peterson BL, et al. Analysis of survival, AML transformation, and transfusion independence in patients with high-risk myelodysplastic syndromes (MDS) receiving azacitidine determined using a prognostic model. ASH Annual Meeting Abstracts. 2005;106:2523.
    • (2005) ASH Annual Meeting Abstracts , vol.106 , pp. 2523
    • Silverman, L.R.1    McKenzie, D.R.2    Peterson, B.L.3
  • 47
    • 34247338444 scopus 로고    scopus 로고
    • Azacitidine prolongs survival and time to AML transformation in high-risk myelodysplastic syndrome (MDS) patients >= 65 years of age
    • Silverman LR, McKenzie DR, Peterson BL, et al. Azacitidine prolongs survival and time to AML transformation in high-risk myelodysplastic syndrome (MDS) patients >= 65 years of age. ASH Annual Meeting Abstracts. 2005;106:2524.
    • (2005) ASH Annual Meeting Abstracts , vol.106 , pp. 2524
    • Silverman, L.R.1    McKenzie, D.R.2    Peterson, B.L.3
  • 48
    • 1542753559 scopus 로고    scopus 로고
    • Revised recommendations of the International Working Group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia
    • Cheson BD, Bennett JM, Kopecky KJ, et al. Revised recommendations of the International Working Group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia. J Clin Oncol. 2003;21:4642-4649.
    • (2003) J Clin Oncol , vol.21 , pp. 4642-4649
    • Cheson, B.D.1    Bennett, J.M.2    Kopecky, K.J.3
  • 49
    • 33750078985 scopus 로고    scopus 로고
    • Treatment of acute myelogenous leukemia with outpatient azacitidine
    • Sudan N, Rossetti JM, Shadduck RK, et al. Treatment of acute myelogenous leukemia with outpatient azacitidine. Cancer. 2006;107:1839-1843.
    • (2006) Cancer , vol.107 , pp. 1839-1843
    • Sudan, N.1    Rossetti, J.M.2    Shadduck, R.K.3
  • 50
    • 34848815313 scopus 로고    scopus 로고
    • Treatment of high risk MDS and AML post-MDS with azacytidine (AZA): Preliminary results of the French ATU program
    • Fabre C, Chermat F, Legros L, et al. Treatment of high risk MDS and AML post-MDS with azacytidine (AZA): preliminary results of the French ATU program. ASH Annual Meeting Abstracts. 2006;108:2664.
    • (2006) ASH Annual Meeting Abstracts , vol.108 , pp. 2664
    • Fabre, C.1    Chermat, F.2    Legros, L.3
  • 51
    • 34848829458 scopus 로고    scopus 로고
    • Hematologic improvement, transfusion independence, and safety assessed using three alternative dosing schedules of azacitidine in patients with myelodysplastic syndromes
    • Lyons RM, Cosgriff T, Modi S, et al. Hematologic improvement, transfusion independence, and safety assessed using three alternative dosing schedules of azacitidine in patients with myelodysplastic syndromes. ASH Annual Meeting Abstracts. 2006;108:2662.
    • (2006) ASH Annual Meeting Abstracts , vol.108 , pp. 2662
    • Lyons, R.M.1    Cosgriff, T.2    Modi, S.3
  • 52
    • 34848928673 scopus 로고    scopus 로고
    • G-CSF Increases hematological response among patients with myelodysplasia treated with azacitidine
    • Rossetti JM, Falke E, Shadduck RK, et al. G-CSF Increases hematological response among patients with myelodysplasia treated with azacitidine. ASH Annual Meeting Abstracts 2006;108:4868.
    • (2006) ASH Annual Meeting Abstracts , vol.108 , pp. 4868
    • Rossetti, J.M.1    Falke, E.2    Shadduck, R.K.3
  • 53
    • 0030974771 scopus 로고    scopus 로고
    • Pilot phase I-II study on 5-aza-2′-deoxycytidine (Decitabine) in patients with metastatic lung cancer
    • Momparler RL, Bouffard DY, Momparler LF, et al. Pilot phase I-II study on 5-aza-2′-deoxycytidine (Decitabine) in patients with metastatic lung cancer. Anti-cancer Drugs. 1997;8:358-368.
    • (1997) Anti-cancer Drugs , vol.8 , pp. 358-368
    • Momparler, R.L.1    Bouffard, D.Y.2    Momparler, L.F.3
  • 54
    • 0034106513 scopus 로고    scopus 로고
    • A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer
    • Schwartsmann G, Schunemann H, Gorini CN, et al. A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer. Invest New Drugs. 2000;18:83-91.
    • (2000) Invest New Drugs , vol.18 , pp. 83-91
    • Schwartsmann, G.1    Schunemann, H.2    Gorini, C.N.3
  • 55
    • 0027221806 scopus 로고
    • 5-Aza-2′-deoxycitidine (Decitabine) induces trilineage response in unfavourable myelodysplastic syndromes
    • Zagonel V, Lo RG, Marotta G, et al. 5-Aza-2′-deoxycitidine (Decitabine) induces trilineage response in unfavourable myelodysplastic syndromes. Leukemia. 1993;7(suppl 1):30-35.
    • (1993) Leukemia , vol.7 , Issue.SUPPL. 1 , pp. 30-35
    • Zagonel, V.1    Lo, R.G.2    Marotta, G.3
  • 56
    • 10744233452 scopus 로고    scopus 로고
    • Phase 1 study of low-dose prolonged exposure schedules of the hypormethytating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
    • Issa JR Garcia-Manero G, Giles FJ, et al. Phase 1 study of low-dose prolonged exposure schedules of the hypormethytating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies. Blood. 2004;103:1635-1640.
    • (2004) Blood , vol.103 , pp. 1635-1640
    • Issa, J.R.1    Garcia-Manero, G.2    Giles, F.J.3
  • 57
    • 0031042482 scopus 로고    scopus 로고
    • Continuous infusion of low-dose 5-Aza-2′-deoxycytidine in elderly patients with high-risk myelodysplastic syndrome
    • Wijermans PW, Krulder JW, Huijgens PC, Neve P. Continuous infusion of low-dose 5-Aza-2′-deoxycytidine in elderly patients with high-risk myelodysplastic syndrome. Leukemia. 1997;11(suppl 1):S19-S23.
    • (1997) Leukemia , vol.11 , Issue.SUPPL. 1
    • Wijermans, P.W.1    Krulder, J.W.2    Huijgens, P.C.3    Neve, P.4
  • 58
    • 17444452612 scopus 로고    scopus 로고
    • Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: A multicenter phase II study in elderly patients
    • Wijermans P, Lubbert M, Verhoef G, et al. Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. J Clin Oncol. 2000; 18:956-962.
    • (2000) J Clin Oncol , vol.18 , pp. 956-962
    • Wijermans, P.1    Lubbert, M.2    Verhoef, G.3
  • 59
    • 0034883005 scopus 로고    scopus 로고
    • Cytogenetic responses in high-risk myelodysplastic syndrome following low-dose treatment with the DNA methylation inhibitor 5-aza-2′-deoxicytidine
    • Lubbert M, Wijermans P, Kunzmann R, et al. Cytogenetic responses in high-risk myelodysplastic syndrome following low-dose treatment with the DNA methylation inhibitor 5-aza-2′-deoxicytidine. Br J Haematol. 2001;114:349-357.
    • (2001) Br J Haematol , vol.114 , pp. 349-357
    • Lubbert, M.1    Wijermans, P.2    Kunzmann, R.3
  • 60
    • 2942594292 scopus 로고    scopus 로고
    • The effects of 5-aza-2′-deoxycytidine (Decitabine) on the platelet count in patients with intermediate and high-risk myelodysplastic syndromes
    • van den BJ, Lubbert M, Verhoef G, Wijermans PW. The effects of 5-aza-2′-deoxycytidine (Decitabine) on the platelet count in patients with intermediate and high-risk myelodysplastic syndromes. Leuk Res. 2004;28:785-790.
    • (2004) Leuk Res , vol.28 , pp. 785-790
    • van den, B.J.1    Lubbert, M.2    Verhoef, G.3    Wijermans, P.W.4
  • 61
    • 33646071894 scopus 로고    scopus 로고
    • Decitabine improves patient outcomes in myelodysplastic syndromes: Results of a phase III randomized study
    • Kantarjian H, Issa JP, Rosenfeld CS, et al. Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study. Cancer. 2006;106:1794-1803.
    • (2006) Cancer , vol.106 , pp. 1794-1803
    • Kantarjian, H.1    Issa, J.P.2    Rosenfeld, C.S.3
  • 62
    • 33846011361 scopus 로고    scopus 로고
    • Results of a randomized study of three schedules of low-dose decitabine in higher risk myelodysplastic syndrome and chronic myelomonocytic leukemia
    • Kantarjian H, Oki Y, Garcia-Manero G, et al. Results of a randomized study of three schedules of low-dose decitabine in higher risk myelodysplastic syndrome and chronic myelomonocytic leukemia. Blood. 2007;109:52-57.
    • (2007) Blood , vol.109 , pp. 52-57
    • Kantarjian, H.1    Oki, Y.2    Garcia-Manero, G.3
  • 63
    • 33646051586 scopus 로고    scopus 로고
    • Superiority of prolonged low-dose azanucleoside administration? Results of 5-aza-2′-deoxycytidine retreatment in high-risk myelodysplasia patients
    • Ruter B, Wijermans PW, Lubbert M. Superiority of prolonged low-dose azanucleoside administration? Results of 5-aza-2′-deoxycytidine retreatment in high-risk myelodysplasia patients. Cancer. 2006;106:1744-1750.
    • (2006) Cancer , vol.106 , pp. 1744-1750
    • Ruter, B.1    Wijermans, P.W.2    Lubbert, M.3
  • 64
    • 33344456652 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: A review of their clinical status as antineoplastic agents
    • Garcia-Manero G, Issa JP. Histone deacetylase inhibitors: a review of their clinical status as antineoplastic agents. Cancer Invest. 2005;23:635-642.
    • (2005) Cancer Invest , vol.23 , pp. 635-642
    • Garcia-Manero, G.1    Issa, J.P.2
  • 65
    • 0034596309 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Inducers of differentiation or apoptosis of transformed cells
    • Marks PA, Richon VM, Rifkind RA. Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells. J Natl Cancer Inst. 2000;92:1210-1216.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1210-1216
    • Marks, P.A.1    Richon, V.M.2    Rifkind, R.A.3
  • 66
    • 0036554808 scopus 로고    scopus 로고
    • Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia
    • Gore SD, Weng LJ, Figg WD, et al. Impact of prolonged infusions of the putative differentiating agent sodium phenylbutyrate on myelodysplastic syndromes and acute myeloid leukemia. Clin Cancer Res. 2002;8:963-970.
    • (2002) Clin Cancer Res , vol.8 , pp. 963-970
    • Gore, S.D.1    Weng, L.J.2    Figg, W.D.3
  • 67
    • 4444309863 scopus 로고    scopus 로고
    • Treatment of myelodysplastic syndromes with valproic acid alone or in combination with all-trans retinoic acid
    • Kuendgen A, Strupp C, Aivado M, et al. Treatment of myelodysplastic syndromes with valproic acid alone or in combination with all-trans retinoic acid. Blood. 2004;104:1266-1269.
    • (2004) Blood , vol.104 , pp. 1266-1269
    • Kuendgen, A.1    Strupp, C.2    Aivado, M.3
  • 68
    • 20544471661 scopus 로고    scopus 로고
    • Increase in platelet count in older, poor-risk patients with acute myeloid leukemia or myelodysplastic syndrome treated with valproic acid and all-trans retinoic acid
    • Pilatrino C, Cilloni D, Messa E, et al. Increase in platelet count in older, poor-risk patients with acute myeloid leukemia or myelodysplastic syndrome treated with valproic acid and all-trans retinoic acid. Cancer. 2005;104:101-109.
    • (2005) Cancer , vol.104 , pp. 101-109
    • Pilatrino, C.1    Cilloni, D.2    Messa, E.3
  • 69
    • 34848814103 scopus 로고    scopus 로고
    • Valproic acid (VPA) achieves high response rates in patients with low-risk myelodysplastic syndromes
    • Kuendgen A, Schmid M, Knipp S, et al. Valproic acid (VPA) achieves high response rates in patients with low-risk myelodysplastic syndromes. ASH Annual Meeting Abstracts. 2005;106:789.
    • (2005) ASH Annual Meeting Abstracts , vol.106 , pp. 789
    • Kuendgen, A.1    Schmid, M.2    Knipp, S.3
  • 70
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron EE, Bachman KE, Myohanen S, Herman JG, Baylin SB. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet. 1999;21:103-107.
    • (1999) Nat Genet , vol.21 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 71
    • 20344394418 scopus 로고    scopus 로고
    • Antileukemia activity of the combination of 5-aza-2′-deoxcytidine with valproic acid
    • Yang H, Hoshino K, Sanchez-Gonzalez B, Kantarjian H, Garcia-Manero G. Antileukemia activity of the combination of 5-aza-2′-deoxcytidine with valproic acid. Leuk Res. 2005;29:739-748.
    • (2005) Leuk Res , vol.29 , pp. 739-748
    • Yang, H.1    Hoshino, K.2    Sanchez-Gonzalez, B.3    Kantarjian, H.4    Garcia-Manero, G.5
  • 72
    • 33750530675 scopus 로고    scopus 로고
    • Phase 1/2 study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia
    • Garcia-Manero G, Kantarjian HM, Sanchez-Gonzalez B, et al. Phase 1/2 study of the combination of 5-aza-2′-deoxycytidine with valproic acid in patients with leukemia. Blood. 2006;108:3271-3279.
    • (2006) Blood , vol.108 , pp. 3271-3279
    • Garcia-Manero, G.1    Kantarjian, H.M.2    Sanchez-Gonzalez, B.3
  • 73
    • 34848833173 scopus 로고    scopus 로고
    • Significant clinical activity of the combination of 5-azacytidine, valproic acid and all-trans retinoic (ATRA) acid in leukemia: Results of a phase I/II study
    • Soriano AO, Yang H, Tong W, et al. Significant clinical activity of the combination of 5-azacytidine, valproic acid and all-trans retinoic (ATRA) acid in leukemia: results of a phase I/II study. ASH Annual Meeting Abstracts. 2006;108:160.
    • (2006) ASH Annual Meeting Abstracts , vol.108 , pp. 160
    • Soriano, A.O.1    Yang, H.2    Tong, W.3
  • 74
    • 33745714230 scopus 로고    scopus 로고
    • Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
    • Gore SD, Baylin S, Sugar E, et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res. 2006;66:6361-6369.
    • (2006) Cancer Res , vol.66 , pp. 6361-6369
    • Gore, S.D.1    Baylin, S.2    Sugar, E.3
  • 75
    • 34848865289 scopus 로고
    • Phase I/II study of the oral isotype-selective histone deacetylase (HDAC) inhibitor MGCD0103 in combination with azacitidine in patients (pts) with high-risk myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML)
    • Garcia-Manero G, Yang AS, Giles F, et al. Phase I/II study of the oral isotype-selective histone deacetylase (HDAC) inhibitor MGCD0103 in combination with azacitidine in patients (pts) with high-risk myelodysplastic syndrome (MDS) or acute myelogenous leukemia (AML). ASH Annual Meeting Abstracts 2006;108:1954.
    • (1954) ASH Annual Meeting Abstracts , vol.108
    • Garcia-Manero, G.1    Yang, A.S.2    Giles, F.3
  • 76
    • 33751177396 scopus 로고    scopus 로고
    • Final results of a phase I study of the histone deacetylase, inhibitor vorinostat (suberoyanilide hydroxamic acid, SAHA), in patients with leukemia and myelodysplastic syndrome
    • Garcia-Manero G, Yang H, Sanchez-Gonzalez B, et al. Final results of a phase I study of the histone deacetylase, inhibitor vorinostat (suberoyanilide hydroxamic acid, SAHA), in patients with leukemia and myelodysplastic syndrome. ASH Annual Meeting Abstracts. 2005;106:2801.
    • (2005) ASH Annual Meeting Abstracts , vol.106 , pp. 2801
    • Garcia-Manero, G.1    Yang, H.2    Sanchez-Gonzalez, B.3
  • 77
    • 34848819070 scopus 로고    scopus 로고
    • Combined methyltransferase/ histone deacetylase inhibition with 5-azacitidine and MS-275 in patients with MDS, CMMoL and AML: Clinical response, histone acetylation and DNA damage
    • Gore SD, Jiemjit A, Silverman LB, et al. Combined methyltransferase/ histone deacetylase inhibition with 5-azacitidine and MS-275 in patients with MDS, CMMoL and AML: clinical response, histone acetylation and DNA damage. ASH Annual Meeting Abstracts. 2006;108:517.
    • (2006) ASH Annual Meeting Abstracts , vol.108 , pp. 517
    • Gore, S.D.1    Jiemjit, A.2    Silverman, L.B.3
  • 78
    • 31744431821 scopus 로고    scopus 로고
    • A phase I/II study of intravenous LBH589, a novel histone deacetylase (HDAC) inhibitor, in patients (pts) with advanced hematologic malignancies
    • Giles FJ, Fischer T, Cortes J, et al. A phase I/II study of intravenous LBH589, a novel histone deacetylase (HDAC) inhibitor, in patients (pts) with advanced hematologic malignancies. ASH Annual Meeting Abstracts. 2004;104:1802.
    • (2004) ASH Annual Meeting Abstracts , vol.104 , pp. 1802
    • Giles, F.J.1    Fischer, T.2    Cortes, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.