Selenium acts as an insulin-like molecule for the down-regulation of diabetic symptoms via endoplasmic reticulum stress and insulin signalling proteins in diabetes-induced non-obese diabetic mice

Journal of Biosciences

Volumn 32, Issue 4, 2007, Pages 723-735

  Hwang, Daeyoun ^a   Seo, Sujin ^a   Kim, Yongkyu ^a   Kim, Chuelkyu ^a   Shim, Sunbo ^a   Jee, Seungwan ^a   Lee, Suhae ^a   Jang, Mikyong ^a   Kim, Minsun ^a   Yim, Suyoun ^a   Lee, Sang Koo ^b   Kang, Byeongcheol ^c   Jang, Insurk ^d   Cho, Jungsik ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b Hanyang University College of Medicine   (South Korea)

^c Seoul National University Hospital   (South Korea)

^d Gyeongsang National University   (South Korea)

Author keywords

Apoptosis; ER stress; Insulin signal; Lipid metabolism; NOD; Selenium

Indexed keywords

DNA FRAGMENT; GLUCOSE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SELENIUM; STRESS ACTIVATED PROTEIN KINASE;

APOPTOSIS; BIOCHEMISTRY; DIABETES; GENE EXPRESSION; GENETIC ANALYSIS; HORMONE; LIPID; METABOLISM; PROTEIN; RODENT; SELENIUM; SERUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIPID METABOLISM; LIVER INJURY; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DOWN-REGULATION; ENDOPLASMIC RETICULUM; INSULIN; MICE; MICE, INBRED NOD; SELENIUM; SIGNAL TRANSDUCTION;

MUS;

EID: 34848887975     PISSN: 02505991     EISSN: 02505991     Source Type: Journal    
DOI: 10.1007/s12038-007-0072-6     Document Type: Article

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