Effect of medium pH on the cytotoxicity of hydrophilic statins

Journal of Pharmacy and Pharmaceutical Sciences

Volumn 10, Issue 3, 2007, Pages 332-339

  Kobayashi, Masaki ^a   Kagawa, Toshiki ^a   Takano, Rumi ^a   Itagaki, Shirou ^a   Hirano, Takeshi ^a   Iseki, Ken ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CASPASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PRAVASTATIN; ROSUVASTATIN; FLUOROBENZENE; PYRIMIDINE DERIVATIVE; SULFONAMIDE; TETRAZOLIUM; THIAZOLE DERIVATIVE; THIAZOLYL BLUE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACCUMULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ASSAY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROPHILICITY; IN VITRO STUDY; NONHUMAN; PH; ANIMAL; CELL LINE; CELL SURVIVAL; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECT; EMBRYONAL RHABDOMYOSARCOMA; METABOLISM; MYOBLAST; RAT; SKELETAL MUSCLE; TOXICITY TESTING;

ANIMALS; APOPTOSIS; CASPASES; CELL LINE; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLUOROBENZENES; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MUSCLE, SKELETAL; MYOBLASTS; PRAVASTATIN; PYRIMIDINES; RATS; RHABDOMYOSARCOMA, EMBRYONAL; SULFONAMIDES; TETRAZOLIUM SALTS; THIAZOLES; TOXICITY TESTS;

EID: 34848887756     PISSN: None     EISSN: 14821826     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Havel, R.J., Rapaport, E., Management of primary hyperlipidemia. New Engl J Med,332:1491-1498, 1995.
2. Jukema, J.W., Bruschke, A.V., van Boven, A.J., Reiber, J.H., Bal, E.T., Zwinderman, A.H., Jansen, H., Boerma, G.J., van Rappard F.M., Lie, K.L. et al., Effects of lipid lowering by pravastatin on progression and regression of coronary artery disease in symptomatic men with normal to moderately elevated serum cholesterol levels. The Regression Growth Evaluation Statin Study (REGRESS). Circulation, 91:2528-2540, 1995.
3. Downs, J.R., Clearfield, M., Weis, S., Whitney, E., Shapiro, D.R., Beere, P.A., Langendorfer, A., Stein, E.A., Kruyer, W., Gotto, A.M.Jr., Primary prevention of acute coronary events with lovastatin in men and women with average cholesterol levels: results of AFCAPS/TexCAPS. Air Force/Texas Coronary Atherosclerosis Prevention Study. JAMA 279:1615-1622, 1998.
4. Omar, M.A., Wilson, J.P., Cox, TS., Rhabdomyolysis and HMG-CoA reductase inhibitors. Ann Pharmacother, 35:1096-1107, 2001. Review. Erratum in: Ann Pharmacother, 35:1296, 2001.
5. Pedersen, T.R., Kjekshus, J., Berg, K., Haghfelt, T., Faergeman, O., Faergeman, G., Pyorala, K., Miettinen, T., Wilhelmsen, L., Olsson, A.G., Wedel, H., Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). 1994. Atheroscler Suppl, 5:81-87, 2004.
6. Maron, D.J., Fazio, S., Linton, M.F., Current perspectives on statins. Circulation, 101:207-213, 2000.
7. Garnett, W.R., Interactions with hydroxymethylglutaryl-coenzyme A reductase inhibitors. Am J Health Syst Pharm, 52:1639-1645, 1995.
8. Maeda, N., Yokota, H., Sugiura, M., Kohama, T., Saito, M., Kurihara, A., Tabata, F., Seda, Y., Relationship between water-octanol partition coefficient and inhibition of proliferation of cultured cell lines among various HMG-CoA reductase inhibitors (Statins).Prog Med, 24: 2517-2523, 2004.
9. Kobayashi, M., Fujita, I., Itagaki, S., Hirano, T., Iseki, K., Transport mechanism for L-lactic acid in human myocytes using human prototypic embryonal rhabdomyosarcoma cell line (RD cells). Biol Pharm Bull, 28:1197-1201, 2005.
10. Kobayashi, M., Itagaki, S., Hirano, T., Iseki, K., Mechanism of L-lactic acid transport in L6 skeletal muscle cells. Drug Metab Pharmacokinet, 19:363-368, 2004.
11. Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol. Methods, 65:55-63, 1983.
12. Lowry, O.H., Rosebrough, N.J., Farr, A.L., Randall, R.J., Protein measurement with the folin phenol reagent. J Biol Chem, 193:265-275, 1951.
13. Kobayashi, M., Kaido, F., Kagawa, T., Itagaki, S., Hirano, T., Iseki, K., Preventive effects of bicarbonate on cerivastatin-induced apoptosis, Int J Pharma in press.
14. Ferri, K.F., Kroemer, G., Organelle-specific initiation of cell death pathways, Nat Cell Biol, 3:255-263, 2001.