-
1
-
-
0035211504
-
Angiogenesis-dependent diseases
-
Folkman J. Angiogenesis-dependent diseases. Semin Oncol 2001;28:536-42.
-
(2001)
Semin Oncol
, vol.28
, pp. 536-542
-
-
Folkman, J.1
-
2
-
-
33750941018
-
Therapeutic options to target angiogenesis in human malignancies
-
Herbst RS. Therapeutic options to target angiogenesis in human malignancies. Expert Opin Emerg Drugs 2006;11:635-50.
-
(2006)
Expert Opin Emerg Drugs
, vol.11
, pp. 635-650
-
-
Herbst, R.S.1
-
3
-
-
0037967272
-
Tumorigenesis and the angiogenic switch
-
Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003;3:401-10.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 401-410
-
-
Bergers, G.1
Benjamin, L.E.2
-
4
-
-
0037531794
-
The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression
-
Hanrahan V, Currie MJ, Gunningham SP, et al. The angiogenic switch for vascular endothelial growth factor (VEGF)-A, VEGF-B, VEGF-C, and VEGF-D in the adenoma-carcinoma sequence during colorectal cancer progression. J Pathol 2003;200:183-94.
-
(2003)
J Pathol
, vol.200
, pp. 183-194
-
-
Hanrahan, V.1
Currie, M.J.2
Gunningham, S.P.3
-
5
-
-
0034499732
-
Vascular endothelial growth factor and the regulation of angiogenesis
-
Ferrara N. Vascular endothelial growth factor and the regulation of angiogenesis. Recent Prog Horm Res 2000;55:15-35.
-
(2000)
Recent Prog Horm Res
, vol.55
, pp. 15-35
-
-
Ferrara, N.1
-
6
-
-
0021111648
-
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
-
Senger DR, Galli SJ, Dvorak AM, et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983;219:983-5.
-
(1983)
Science
, vol.219
, pp. 983-985
-
-
Senger, D.R.1
Galli, S.J.2
Dvorak, A.M.3
-
7
-
-
14644440555
-
Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
-
Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005;23:1011-27.
-
(2005)
J Clin Oncol
, vol.23
, pp. 1011-1027
-
-
Hicklin, D.J.1
Ellis, L.M.2
-
9
-
-
0029937679
-
The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency
-
Keyt BA, Berleau LT, Nguyen HV, et al. The carboxyl-terminal domain (111-165) of vascular endothelial growth factor is critical for its mitogenic potency. J Biol Chem 1996;271:7788-95.
-
(1996)
J Biol Chem
, vol.271
, pp. 7788-7795
-
-
Keyt, B.A.1
Berleau, L.T.2
Nguyen, H.V.3
-
10
-
-
0036842215
-
Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
-
Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002;20:4368-80.
-
(2002)
J Clin Oncol
, vol.20
, pp. 4368-4380
-
-
Dvorak, H.F.1
-
11
-
-
19244379078
-
Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
-
Carmeliet P, Moons L, Luttun A, et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions. Nat Med 2001;7:575-83.
-
(2001)
Nat Med
, vol.7
, pp. 575-583
-
-
Carmeliet, P.1
Moons, L.2
Luttun, A.3
-
12
-
-
0025259592
-
Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase (flt) closely related to the fms family
-
Shibuya M, Yamaguchi S, Yamane A, et al. Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase (flt) closely related to the fms family. Oncogene 1990;5:519-24.
-
(1990)
Oncogene
, vol.5
, pp. 519-524
-
-
Shibuya, M.1
Yamaguchi, S.2
Yamane, A.3
-
13
-
-
0026702970
-
Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor
-
Terman B. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem Biophys Res Commun 1992;187:1579-86.
-
(1992)
Biochem Biophys Res Commun
, vol.187
, pp. 1579-1586
-
-
Terman, B.1
-
14
-
-
0036527585
-
Molecular mechanisms of lymphangiogenesis in health and disease
-
Alitalo K, Carmeliet P. Molecular mechanisms of lymphangiogenesis in health and disease. Cancer Cell 2002;1:219-27.
-
(2002)
Cancer Cell
, vol.1
, pp. 219-227
-
-
Alitalo, K.1
Carmeliet, P.2
-
15
-
-
31744449858
-
Development of angiogenesis inhibitors to vascular endothelial growth factor receptor 2. Current status and future perspective
-
Paz K, Zhu Z. Development of angiogenesis inhibitors to vascular endothelial growth factor receptor 2. Current status and future perspective. Front Biosci 2005;10:1415-39.
-
(2005)
Front Biosci
, vol.10
, pp. 1415-1439
-
-
Paz, K.1
Zhu, Z.2
-
16
-
-
13544255403
-
The pathophysiologic role of VEGF in hematologic malignancies: Therapeutic implications
-
Podar K, Anderson KC. The pathophysiologic role of VEGF in hematologic malignancies: therapeutic implications. Blood 2005;105:1383-95.
-
(2005)
Blood
, vol.105
, pp. 1383-1395
-
-
Podar, K.1
Anderson, K.C.2
-
17
-
-
0035283119
-
Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes
-
Bellamy WT, Richter L, Sirjani D, et al. Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes. Blood 2001;97:1427-34.
-
(2001)
Blood
, vol.97
, pp. 1427-1434
-
-
Bellamy, W.T.1
Richter, L.2
Sirjani, D.3
-
18
-
-
0032714247
-
Melanoma-associated expression of vascular endothelial growth factor and its receptors FLT-1 and KDR
-
Graeven U, Fiedler W, Karpinski S, et al. Melanoma-associated expression of vascular endothelial growth factor and its receptors FLT-1 and KDR. J Cancer Res Clin Oncol 1999;125:621-9.
-
(1999)
J Cancer Res Clin Oncol
, vol.125
, pp. 621-629
-
-
Graeven, U.1
Fiedler, W.2
Karpinski, S.3
-
19
-
-
0034518226
-
Human melanoma cells secrete and respond to placenta growth factor and vascular endothelial growth factor
-
Lacal PM, Failla CM, Pagani E, et al. Human melanoma cells secrete and respond to placenta growth factor and vascular endothelial growth factor. J Invest Dermatol 2000;115:1000-7.
-
(2000)
J Invest Dermatol
, vol.115
, pp. 1000-1007
-
-
Lacal, P.M.1
Failla, C.M.2
Pagani, E.3
-
20
-
-
0031469819
-
Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
-
Boehm T, Folkman J, Browder T, et al. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature 1997;390:404-7.
-
(1997)
Nature
, vol.390
, pp. 404-407
-
-
Boehm, T.1
Folkman, J.2
Browder, T.3
-
21
-
-
33846879810
-
The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma
-
s
-
Kaelin WG, Jr. The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma. Clin Cancer Res 2007;13:680-4s.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 680-684
-
-
Kaelin Jr., W.G.1
-
22
-
-
0032698140
-
Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors
-
Prewett M, Huber J, Li Y, et al. Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis and growth of several mouse and human tumors. Cancer Res 1999;59:5209-18.
-
(1999)
Cancer Res
, vol.59
, pp. 5209-5218
-
-
Prewett, M.1
Huber, J.2
Li, Y.3
-
23
-
-
19944422751
-
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metalloproteinases
-
Winkler F, Kozin SV, Tong RT, et al. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell 2004;6:553-63.
-
(2004)
Cancer Cell
, vol.6
, pp. 553-563
-
-
Winkler, F.1
Kozin, S.V.2
Tong, R.T.3
-
24
-
-
0035132923
-
Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts
-
Kozin SV, Boucher Y, Hicklin DJ, et al. Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts. Cancer Res 2001;61:39-44.
-
(2001)
Cancer Res
, vol.61
, pp. 39-44
-
-
Kozin, S.V.1
Boucher, Y.2
Hicklin, D.J.3
-
25
-
-
0037058302
-
Effect of the vascular endothelial growth factor receptor-2 antibody DC101 plus gemcitabine on growth, metastasis and angiogenesis of human pancreatic cancer growing orthotopically in nude mice
-
Bruns CJ, Shrader M, Harbison MT, et al. Effect of the vascular endothelial growth factor receptor-2 antibody DC101 plus gemcitabine on growth, metastasis and angiogenesis of human pancreatic cancer growing orthotopically in nude mice. Int J Cancer 2002;102:101-8.
-
(2002)
Int J Cancer
, vol.102
, pp. 101-108
-
-
Bruns, C.J.1
Shrader, M.2
Harbison, M.T.3
-
26
-
-
34848914981
-
-
Available from
-
Available from: http://www.gene.com/gene/products/information/pdf/ avastin-prescribing.pdf.
-
-
-
-
27
-
-
34848842317
-
-
Available from
-
Available from: http://www.pfizer.com/pfizer/download/uspi_sutent.pdf.
-
-
-
-
28
-
-
34848861527
-
-
Available from
-
Available from: http://www.univgraph.com/bayer/inserts/nexavar.pdf.
-
-
-
-
29
-
-
33744513575
-
Sorafenib (BAY 43-9006, Nexavar®), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature
-
Adnane L, Trail PA, Taylor I, et al. Sorafenib (BAY 43-9006, Nexavar®), a dual-action inhibitor that targets RAF/MEK/ERK pathway in tumor cells and tyrosine kinases VEGFR/PDGFR in tumor vasculature. Methods Enzymol 2005;407:597-612.
-
(2005)
Methods Enzymol
, vol.407
, pp. 597-612
-
-
Adnane, L.1
Trail, P.A.2
Taylor, I.3
-
30
-
-
33644684217
-
Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment
-
Strumberg D. Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment. Drugs Today (Barc) 2005;41:773-84.
-
(2005)
Drugs Today (Barc)
, vol.41
, pp. 773-784
-
-
Strumberg, D.1
-
31
-
-
33749505836
-
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomized controlled trial
-
Demetri GD, van Oosterom AT, Garrett CR, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomized controlled trial. Lancet 2006;368:1329-38.
-
(2006)
Lancet
, vol.368
, pp. 1329-1338
-
-
Demetri, G.D.1
van Oosterom, A.T.2
Garrett, C.R.3
-
32
-
-
33746261239
-
Sunitinib: A newly approved small-molecule inhibitor of angiogenesis
-
Cabebe E, Wakelee H. Sunitinib: A newly approved small-molecule inhibitor of angiogenesis. Drugs Today (Barc) 2006;42:387-98.
-
(2006)
Drugs Today (Barc)
, vol.42
, pp. 387-398
-
-
Cabebe, E.1
Wakelee, H.2
-
35
-
-
0034879569
-
Technology evaluation: IMC-1C11, ImClone Systems
-
Hunt, S. Technology evaluation: IMC-1C11, ImClone Systems. Curr Opin Mol Ther 2001;3:418-24.
-
(2001)
Curr Opin Mol Ther
, vol.3
, pp. 418-424
-
-
Hunt, S.1
-
36
-
-
0037386937
-
A phase I study of antikinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma
-
Posey JA, Ng TC, Yang B, et al. A phase I study of antikinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma. Clin Cancer Res 2003;9:1323-32.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 1323-1332
-
-
Posey, J.A.1
Ng, T.C.2
Yang, B.3
-
37
-
-
33751418762
-
A phase I dose-escalation study of weekly IMC-1121B, a fully human anti-vascular endothelial growth factor receptor 2 (VEGFR2) IgG1 monoclonal antibody (Mab), in patients (pts) with advanced cancer
-
Camidge DR, Eckhardt SG, Diab S, et al. A phase I dose-escalation study of weekly IMC-1121B, a fully human anti-vascular endothelial growth factor receptor 2 (VEGFR2) IgG1 monoclonal antibody (Mab), in patients (pts) with advanced cancer. J Clin Oncol Suppl 2006;24:3032.
-
(2006)
J Clin Oncol Suppl
, vol.24
, pp. 3032
-
-
Camidge, D.R.1
Eckhardt, S.G.2
Diab, S.3
-
38
-
-
34548052276
-
A phase I dose-escalation study of weekly IMC-1121B, a fully human anti-vascular endothelial growth factor receptor 2 (VEGFR2) IgG1 monoclonal antibody (Mab) in patients (pts) with advanced cancer
-
Cohen R, Camidge D, Diab S, et al. A phase I dose-escalation study of weekly IMC-1121B, a fully human anti-vascular endothelial growth factor receptor 2 (VEGFR2) IgG1 monoclonal antibody (Mab) in patients (pts) with advanced cancer. Eur J Cancer Suppl 2006;4:195.
-
(2006)
Eur J Cancer Suppl
, vol.4
, pp. 195
-
-
Cohen, R.1
Camidge, D.2
Diab, S.3
|