Residence time dispersion as a general measure of drug distribution kinetics: Estimation and physiological interpretation

Pharmaceutical Research

Volumn 24, Issue 11, 2007, Pages 2025-2030

  Weiss, Michael ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Diffusion; Distribution; Pharmacokinetics; Residence time; Tissue binding

Indexed keywords

ALFENTANIL; DIGOXIN; FENTANYL; INULIN;

ANALYTICAL PARAMETERS; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALCULATION; CONTROLLED STUDY; DRUG BINDING; DRUG CLEARANCE; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG PENETRATION; HEART OUTPUT; HUMAN; HUMAN EXPERIMENT; NONHUMAN; NORMAL HUMAN; PHYSIOLOGY; PRIORITY JOURNAL; TIME; TISSUE DISTRIBUTION;

ALFENTANIL; ANIMALS; DIGOXIN; FENTANYL; HUMANS; INULIN; METABOLIC CLEARANCE RATE; PHARMACOKINETICS;

EID: 34848883639     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-007-9332-2     Document Type: Article

References (26)

1. M. Weiss. Moments of physiological transit time distributions and the time course of drug disposition in the body. J. Math. Biol. 15:305-318 (1982).
2. M. Weiss. The relevance of residence time theory to pharmacokinetics. Eur. J. Clin. Pharmacol. 43:571-579 (1992).
3. M. Weiss and K. S. Pang. The dynamics of drug distribution. I. Role of the second and third curve moment. J. Pharmacokinet. Biopharm. 20:253-278 (1992).
4. H. Sato, S. Sato, Y. M. Wang, and I. Horikoshi. Add-in macros for rapid and versatile calculation of non-compartmental pharmacokinetic parameters on Microsoft Excel spreadsheets. Comput. Methods Programs Biomed. 50:43-52 (1996).
5. M. Weiss. Mechanistic modeling of digoxin distribution kinetics incorporating slow tissue binding. Eur. J. Pharm. Sci. 30:256-263 (2007).
6. M. Weiss, T. C. Krejcie, and M. J. Avram. Circulatory transport and capillary-tissue exchange as determinants of the distribution kinetics of inulin and antipyrine in dog. J. Pharm. Sci. 96:913-926 (2007).
7. M. Weiss. Generalizations in linear pharmacokinetics using properties of certain classes of residence time distributions. I. Log-convex drug disposition curves. J. Pharmacokinet. Biopharm. 14:635-657 (1986).
8. M. Weiss, G. H. Hübner, I. G. Hübner, and W. Teichmann. Effects of cardiac output on disposition kinetics of sorbitol: recirculatory modelling. Br. J. Clin. Pharmacol. 41:261-268 (1996).
9. M. Weiss, T. C. Krejcie, and M. J. Avram. Transit time dispersion in the pulmonary and systemic circulation: Effects of cardiac output and solute diffusivity. Am. J. Physiol. Heart Circ. Physiol. 291:861-870 (2006).
10. M. Weiss. Hemodynamic influences upon the variance of disposition residence time distribution of drugs. J. Pharmacokinet. Biopharm. 11:63-75 (1983).
11. M. Weiss and A. Ring. Interpretation of general measures of distribution kinetics in terms of a mammillary compartmental model. J. Pharm. Sci. 86:1491-1493 (1997).
12. M. Weiss and M. S. Roberts. Tissue distribution kinetics as determinant of transit time dispersion of drugs in organs: application of a stochastic model to the rat hindlimb. J. Pharmacokinet. Biopharm. 24:173-196 (1996).
13. M. Weiss. Cellular pharmacokinetics: effects of cytoplasmic diffusion and binding on organ transit time distribution. J. Pharmacokinet. Biopharm. 27:233-255 (1999).
14. W. G. Kramer, R. P. Lewis, T. C. Cobb, W. F. Forester Jr, J. A. Visconti, L. A. Wanke, H. G. Boxenbaum, and R. H. Reuning. Pharmacokinetics of digoxin: comparison of a two- and a three-compartment model in man. J. Pharmacokinet. Biopharm. 2:299-312 (1974).
15. T. C. Krejcie, T. K. Henthorn, W. B. Gentry, C. U. Niemann, C. Enders-Klein, C. A. Shanks, and M. J. Avram. Modifications of blood volume alter the disposition of markers of blood volume, extracellular fluid, and total body water. J. Pharmacol. Exp. Ther. 291:1308-1316 (1999).
16. D. Z. D'Argenio and A. Schumitzky. ADAPT II User's guide: Pharmacokinetic/Pharmacodynamic Systems Analysis Software. Biomedical Simulations Resource, Los Angeles, 1997.
17. R. D. Purves. Numerical estimation of the noncompartmental pharmacokinetic parameters variance and coefficient of variation of residence times. J. Pharm. Sci. 83:202-205 (1994).
18. M. Looby and M. Weiss. Accuracy of noncompartmental pharmacokinetic parameters estimated from bolus injection and steady-state infusion data. J. Pharmacokinet. Biopharm. 23:635-649 (1995).
19. C. U. Niemann, T. K. Henthorn, T. C. Krejcie, C. A. Shanks, C. Enders-Klein, and M. J. Avram. Indocyanine green kinetics characterize blood volume and flow distribution and their alteration by propranolol. Clin. Pharmacol. Ther. 67:342-350 (2000).
20. L. F. Prescott, J. A. McAuslane, and S. Freestone. The concentration-dependent disposition and kinetics of inulin. Eur. J. Clin. Pharmacol. 40:619-624 (1991).
21. + pump regulation and skeletal muscle contractility. Physiol. Rev. 83:1269-1324 (2003).
22. H. J. Lemmens, J. B. Dyck, S. L. Shafer, and D. R. Stanski. Pharmacokinetic-pharmacodynamic modeling in drug development: application to the investigational opioid trefentanil. Clin. Pharmacol. Ther. 56:261-271 (1994).
23. S. Bjorkman, D. R. Wada, D. R. Stanski, and W. F. Ebling. Comparative physiological pharmacokinetics of fentanyl and alfentanil in rats and humans based on parametric single-tissue models. J. Pharmacokinet. Biopharm. 22:381-410 (1994).
24. T. K. Henthorn, T. C. Krejcie, and M. J. Avram. The relationship between alfentanil distribution kinetics and cardiac output. Clin. Pharmacol. Ther. 52:190-196 (1992).
25. T. D. Egan, S. Kuramkote, G. Gong, J. Zhang, S. W. McJames, and P. L. Bailey. Fentanyl pharmacokinetics in hemorrhagic shock: a porcine model. Anesthesiology. 91:156-166 (1999).
26. J. M. Bailey. A technique for calculating the mean time for equilibration of drug distribution using minimal structural assumptions. J. Pharmacokinet. Biopharm. 22:157-164 (1994).