T cells specific to hapten-carrier but not to carrier alone assist in the production of anti-hapten and anti-carrier antibodies

International Immunology

Volumn 19, Issue 10, 2007, Pages 1157-1164

  Shimizu, Takeyuki ^a,b   Osaka, Yuko ^a   Banri Koike, Chihiro ^a   Yoshida, Maiko ^a   Endo, Kanako ^a   Furukawa, Koji ^a,c   Oda, Masayuki ^a,d   Murakami, Akikazu ^a   Ogawa, Shuhei ^a   Abe, Ryo ^a   Azuma, Takachika ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^d KYOTO PREFECTURAL UNIVERSITY   (Japan)

Author keywords

Antigenicity; B lymphocyte; Hapten carrier immunization; T lymphocyte; TD antigen

Indexed keywords

ALBUMIN; CARRIER PROTEIN; HAPTEN; OVALBUMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIGEN RECOGNITION; ARTICLE; B LYMPHOCYTE; CELL SPECIFICITY; CHEMICAL MODIFICATION; CONTROLLED STUDY; HAPTEN CARRIER COMPLEX; IMMUNE RESPONSE; IMMUNIZATION; LYMPHOCYTE ACTIVATION; LYMPHOCYTOPOIESIS; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; ANTIBODIES; ANTIBODY FORMATION; ANTIGENS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; HAPTENS; IMMUNIZATION; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; OVALBUMIN; OXAZOLONE;

EID: 34848853301     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxm080     Document Type: Article

References (31)

1. Eisen, H. N. and Siskind, G. W. 1964. Variations in affinities of antibodies during the immune response. Biochemistry 155:996.
2. Milstein, C. 1985. From the structure of antibodies to the diversification of the immune response. EMBO J. 4:1083.
3. Rock, K. L., Benacerraf, B. and Abbas, A. K. 1984. Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. J. Exp. Med. 160:1102.
4. Malynn, B. A., Romeo, D. T. and Wortis, H. H. 1985. Antigen-specific B- cells efficiently present low doses of antigen for induction of T cell proliferation. J. Immunol. 135:980.
5. Rao, A., Faas, S. J. and Cantor, H. 1984. Activation specificity of arsonate-reactive T cell clones. Structural requirements for hapten recognition and comparison with monoclonal antibodies. J. Exp. Med. 159:479.
6. Martin, S., Ruh, H., Hebbelmann, S., Pflugfelder, U., Rude, B. and Weltzien, H. U. 1995. Carrier-reactive hapten-specific cytotoxic T lymphocyte clones originate from a highly preselected T cell repertoire: implications for chemical-induced self-reactivity. Eur. J. Immunol. 25:2788.
7. + T cell priming for contact hypersensitivity occurs independently of CD40-CD154 interactions: J. Immunol. 166:2323.
8. Stockl, J., Majdic, O., Fischer, G., Maurer, D. and Knapp, W. 2001. Monomorphic molecules function as additional recognition structures on haptenated target cells for HLA-A1-restricted, hapten-specific CTL. J. Immunol. 167:2724.
9. Ortmann, B., Martin, S., von Bonin, A., Schiltz, E., Hoschutzky, H and Weltzien, H. U. 1992. Synthetic peptides anchor T cell-specific TNP epitopes to MHC antigens. J. Immunol. 148:1445.
10. von Bonin, A., Ortmann, B., Martin, S. and Weltzien, H. U. 1992. Peptide-conjugated hapten groups are the major antigenic determinants for trinitrophenyl-specific cytotoxic T cells. Int. Immunol. 4:869.
11. Nalefski, E. A. and Rao, A. 1993. Nature of the ligand recognized by a hapten- and carrier-specific, MHC-restricted T cell receptor. J. Immunol. 150:3806.
12. Jang, Y. S., Lim, K. H. and Kim, B. S. 1991. Analysis of T cell reactivities to phosphorylcholine-conjugated hen egg lysozyme in C57BL/6 mice: Hapten-conjugate specificity reflects an altered expression of a major carrier epitope. Eur. J. Immunol. 21:1303.
13. Preckel, T., Breloer, M., Kohler, H., von Bonin, A. and Weltzien, H. U. 1998. Partial agonism and independent modulation of T cell receptor and CD8 in hapten-specific cytotoxic T cells. Eur. J. Immunol. 28:3706.
14. Katz, D. H., Paul, W. E., Goidl, E. A. and Benacerraf, B. 1970. Carrier function in anti-hapten immune responses. I. Enhancement of primary and secondary anti-hapten antibody responses by carrier preimmunization. J. Exp. Med. 132:261.
15. Michaelsson, E., Malmstrom, V., Reis, S., Engstrom, A., Burkhardt, H. and Holmdahl, R. 1994. T cell recognition of carbohydrates on type II collagen. J. Exp. Med. 180:745.
16. Weltzien, H. U., Moulon, C., Martin, S., Padovan, E., Hartmann, U. and Kohler, J. 1996. T cell immune responses to haptens. Structural models for allergic and autoimmune reactions. Toxicology 107:141.
17. Padovan, E., von Greyerz, S., Pichler, W. J. and Weltzien, H. U. 1999. Antigen-dependent and -independent IFN-γ modulation by penicillins. J. Immunol. 162:1171.
18. Romagnoli, P., Labhardt, A. M. and Sinigaglia, F. 1991. Selective interaction of Ni with an MHC-bound peptide. EMBO J. 10:1303.
19. Makela, O., Kaartinen, M., Pelkonen, J. L. and Karjalainen, K. 1978. Inheritance of antibody specificity V Anti-2-phenyloxazolone in the mouse. J. Exp. Med. 148:1644.
20. Griffiths, G. M., Berek, C., Kaartinen, M. and Milstein, C. 1984. Somatic mutation and the maturation of immune response to 2-phenyloxazolone. Nature 312:271.
21. Oda, M. and Azuma, T. 2000. Reevaluation of stoichiometry and affinity/ avidity in interactions between anti-hapten antibodies and mono- or multi-valent antigens. Mol. Immunol. 37:1111.
22. Birnboim, H. C., Lemay, A. M., Lam, D. K., Goldstein, R. and Webb, J. R. 2003. Cutting edge: MHC class II-restricted peptides containing the inflammation-associated marker 3-nitrotyrosine evade central tolerance and elicit a robust cell-mediated immune response. J. Immunol. 171:528.
23. Abraham, R., Choudhury, A., Basu, S. K., Bal, V. and Rath, S. 1997. Disruption of T cell tolerance by directing a self antigen to macrophage-specific scavenger receptors. J. Immunol. 158:4029.
24. Choudhury, A., Mukherjee, P., Basu, S. K., George, A., Rath, S. and Bal, V. 2000. Disruption of T cell tolerance to self-immunoglobulin causes polyclonal B cell stimulation followed by inactivation of responding autoreactive T cells. J. Immunol. 164:1713.
25. Shimonkevitz, R., Colon, S., Kappler, J. W., Marrack, P. and Grey, H. M. 1984. Antigen recognition by H-2-restricted T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen. J. Immunol. 133:2067.
26. Lazarski, C. A., Chaves, F. A., Jenks, S. A. et al. 2005. The kinetic stability of MHC class II:pEptide complexes is a key parameter that dictates immunodominance. Immunity 23:29.
27. Franco, A., Yokoyama, T., Huynh, D., Thomson, C., Nathenson, S. G. and Grey, H. M. 1999. Fine specificity and MHC restriction of trinitrophenyl-specific CTL. J. Immunol. 162:3388.
28. McReynolds, L., O'Malley, B. W., Nisbet, A. D. et al. 1978. Sequence of chicken ovalbumin mRNA. Nature 273:723.
29. Cochran, J. R., Cameron, T. O. and Stern, L. J. 2000. The relationship of MHC-peptide binding and T cell activation probed using chemically defined MHC class II oligomers. Immunity 12:241.
30. Stone, J. D. and Stern, L. J. 2006. CD8 T cells, like CD4 T cells, are triggered by multivalent engagement of TCRs by MHC-peptide ligands but not by monovalent engagement. J. Immunol. 176:1498.
31. Schutze, M. P., Deriaud, E., Przewlocki, G. and LeClerc, C. 1989. Carrier-induced epitopic suppression is initiated through clonal dominance. J. Immunol. 142:2635.