Modulation of CD4 co-receptor limits spontaneous autoimmunity when high-affinity transgenic TCR specific for self-antigen is expressed on a genetically resistant background

International Immunology

Volumn 19, Issue 10, 2007, Pages 1235-1248

  Illés, Zsolt ^a   Waldner, Hanspeter ^a   Reddy, Jayagopala ^a   Anderson, Ana C ^a   Sobel, Raymond A ^b,c   Kuchroo, Vijay K ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Anergy; EAE MS; Suppression; T lymphocytes; Tolerance

Indexed keywords

AUTOANTIGEN; CD3 ANTIBODY; CD4 ANTIGEN; PROTEOLIPID PROTEIN; PROTEOLIPID PROTEIN 139-151; UNCLASSIFIED DRUG;

ADOPTIVE TRANSFER; ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CELL SELECTION; CONTROLLED STUDY; GENETIC RESISTANCE; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SPLEEN CELL; T LYMPHOCYTE; THYMOCYTE; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; ANTIGENS, CD4; AUTOANTIGENS; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; MICE; MICE, TRANSGENIC; MYELIN PROTEOLIPID PROTEIN; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; SPLEEN; THYMUS GLAND; UP-REGULATION;

EID: 34848839897     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxm094     Document Type: Article

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