Key role of uridine kinase and uridine phosphorylase in the homeostatic regulation of purine and pyrimidine salvage in brain

Neurochemistry International

Volumn 51, Issue 8, 2007, Pages 517-523

  Balestri, Francesco ^a   Barsotti, Catia ^a   Lutzemberger, Ludovico ^a   Camici, Marcella ^a   Ipata, Piero Luigi ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

5 Phosphoribosyl 1 pyrophosphate; Purine and pyrimidine homeostasis; Ribose 1 phosphate; Salvage pathways; Uridine kinase; Uridine phosphorylase

Indexed keywords

BETA ALANINE; CYTIDINE TRIPHOSPHATE; PHOSPHORIBOSYL PYROPHOSPHATE; PURINE; PYRIMIDINE; RIBOSE 1 PHOSPHATE; URIDINE; URIDINE KINASE; URIDINE PHOSPHORYLASE; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTOMA; CATALYSIS; CONTROLLED STUDY; ENZYME REGULATION; HOMEOSTASIS; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BRAIN; BRAIN CHEMISTRY; CYTIDINE TRIPHOSPHATE; HOMEOSTASIS; HUMANS; MALE; NUCLEIC ACIDS; NUCLEOSIDES; PHOSPHORIBOSYL PYROPHOSPHATE; PURINES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RIBOSEMONOPHOSPHATES; SUBCELLULAR FRACTIONS; TUMOR CELLS, CULTURED; URIDINE KINASE; URIDINE PHOSPHORYLASE; URIDINE TRIPHOSPHATE;

MAMMALIA; RATTUS;

EID: 34848837912     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2007.06.007     Document Type: Article

References (45)

1. Allewell N.M. Escherichia coli aspartate transcarbamoylase: structure, energetics, and catalytic and regulatory mechanisms. Annu. Rev. Biophys. Biophys. Chem. 18 (1989) 71-92
2. Balestri F., Giannecchini M., Sgarrella F., Carta M.C., Tozzi M.G., and Camici M. Purine and pyrimidine nucleosides preserve human astrocytoma cell adenylate energy charge under ischemic conditions. Neurochem. Int. 50 (2007) 517-523
3. Barsotti C., Tozzi M.G., and Ipata P.L. Purine and pyrimidine salvage in whole rat brain. Utilization of ATP-derived ribose-1-phosphate and 5-phosphoribosyl-1-pyrophosphate generated in experiments with dialyzed cell-free extracts. J. Biol. Chem. 277 (2002) 9865-9869
4. Becroft D.M., Phillips L.I., and Simmonds A. Hereditary orotic aciduria: long-term therapy with uridine and a trial of uracil. J. Pediatr. 75 (1969) 885-891
5. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1979) 248-254
6. Cansev M. Uridine and cytidine in the brain: their trasport and utilization. Brain Res. Rev. 52 (2006) 389-397
7. Cao D., Leffert J.J., McCabe J., Bradford K., and Pizzorno G. Abnormalities in uridine homeostatic regulation and pyrimidine nucleotide metabolism as a consequence of the deletion of the uridine phosphorylase gene. J. Biol. Chem. 280 (2005) 21169-21175
8. Cappiello M., Mascia L., Scolozzi C., Giorgelli F., and Ipata P.L. In vitro assessment of salvage pathways for pyrimidine bases in rat liver and brain. Biochim. Biophys. Acta 1425 (1998) 273-281
9. Cheng N., Payne R.C., and Traut T.W. Regulation of uridine kinase. Evidence for a regulatory site. J. Biol. Chem. 261 (1986) 13006-13012
10. Connolly P.C., and Duley J.A. Uridine and its nucleotides: biological actions, therapeutic potentials. Trends Pharmacol. Sci. 20 (1999) 218-225
11. Connolly G.P., Simmonds H.A., and Duley J.A. Pyrimidines and CNS regulation. Trends Pharmacol. Sci. 17 (1996) 106-107
12. Crawford C.R., Patel D.H., Naeve C., and Belt J.A. Cloning of the human equilabrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line. J. Biol. Chem. 273 (1998) 5288-5293
13. Dagani F., Marzatico F., Curti D., Taglietti M., Zanada F., and Benzi G. Influence of intermittent hypoxia and pyrimidinic nucleosides on cerebral enzymatic activities related to energy transduction. Neurochem. Res. 9 (1984) 1085-1099
14. Darnowski J.W., Handschumacher R.E., Wiegand R.A., Goulette F.A., and Calabresi P. Tissue-specific expansion of uridine pools in mice. Effects of benzylacyclouridine, dipyridamole and exogenous uridine. Biochem. Pharmacol. 41 (1991) 2031-2036
15. England P., and Herve G. Involvement of the gamma-phosphate of UTP in the synergistic inhibition of Escherichia coli aspartate transcarbamylase by CTP and UTP. Biochemistry 33 (1994) 3913-3918
16. Gonzalez F.J., and Fernandez-Salguero P. Diagnostic analysis, clinical importance and molecular basis of dihydropyrimidine dehydrogenase deficiency. Trends Pharmacol. Sci. 16 (1995) 325-327
17. Griffith D.A., and Jarvis S.M. Nucleoside and nucleoside transport systems of mammalian cells. Biochim. Biophys. Acta 1286 (1996) 153-181
18. Honda K., Okano Y., Komoda, and Inoue S. Sleep-promoting effects of intraperitoneally administered uridine in unrestrained rats. Neurosci. Lett. 62 (1985) 137-141
19. Inoue S., Honda K., and Komoda Y. Sleep as neuronal detoxification and restitution. Behav. Brain Res. 69 (1995) 91-96
20. Jones M.E. Pyrimidine nucleotide biosynthesis in animals: genes, enzymes, and regulation of UMP biosynthesis. Annu. Rev. Biochem. 49 (1980) 253-279
21. Jurkowitz M.S., Litsky M.J., Browning M.J., and Hohl C.M. Adenosine, inosine and guanosine protect glial cells during glucose deprivation and mitochondrial inhibition: correlation between protection and ATP preservation. J. Neurochem. 71 (1998) 535-548
22. Karle J.M., Anderson L.W., and Cysyk R.L. Effect of plasma concentrations of uridine on pyrimidine biosynthesis in cultured L1210 cells. J. Biol. Chem. 259 (1984) 67-72
23. Kim Y.A., King M.T., Teague Jr. W.E., Rufo Jr. G.A., Veech R.L., and Passonneau R.L. Regulation of the purine salvage pathway in rat liver. Am. J. Physiol. 262 (1992) E344-E352
24. Kimura N., and Shimada N. Membrane-associated nucleoside diphosphate kinase from rat liver. Purification, characterization, and comparison with cytosolic enzyme. J. Biol. Chem. 263 (1988) 4647-4653
25. Kornberg A., Lieberman I., and Simms E.S. Enzymatic synthesis and properties of 5-phosphoribosylpyrophosphate. J. Biol. Chem. 215 (1955) 389-402
26. Löffler M., Fairbanks L.D., Zameitat E., Marinaki A.M., and Simmonds H.A. Pyrimidine pathways in health and disease. Trends Mol. Med. 11 (2005) 430-437
27. Mascia L., and Ipata P.L. Activation pathways of 5-fluorouracil in rat organs and in PC12 cells. Biochem. Pharmacol. 62 (2001) 213-238
28. Moyer J.D., and Henderson J.F. Salvage of uridine in the mouse. Effect of uridine phosphorylase pretreatment. Biochem. Pharmacol. 34 (1985) 101-105
29. Murray A.W. The biological significance of purine salvage. Annu. Rev. Biochem. 40 (1971) 811-826
30. Nagai K., Nagasawa K., and Fujimoto S. Transport mechanisms for adenosine and uridine in primary-cultured rat cortical neurons and astrocytes. Biochem. Biophys. Res. Commun. 334 (2005) 1343-1350
31. Natsumeda Y., Ikegami T., Olah E., and Weber G. Significance of purine salvage in circumventing the action of antimetabolites in rat hepatoma cells. Cancer Res. 49 (1989) 88-92
32. Page T., Yu A., Fontanesi J., and Nyhan W.L. Developmental disorder associated with increased cellular nucleotidase activity. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 11601-11606
33. Pasti C., Gallois-Montbrun S., Munier-Lehamn H., Veron M., Gilles A.-M., and Deville-Bonne D. Reaction of human UMP-CMP kinase with natural and analog substrates. Eur. J. Biochem. 270 (2003) 1784-1790
34. Pizzorno C., Wiegand R.A., Lentz S.K., and Handschumacher R.E. Brequinar potentiates 5-fluorouracil antitumor activity in a murine model colon 38 tumor by tissue-specific modulation of uridine nucleotide pools. Cancer Res. 52 (1992) 1660-1665
35. Pizzorno G., Cao D., Leffert J.J., Russell R.L., Zhang D., and Handschumacher R.E. Homeostatic control of uridine and the role of uridine phosphorylase: a biological and clinical update. Biochim. Biophys. Acta 1587 (2002) 133-144
36. Reichard P., and Sköld O. Enzymes of uracil metabolism in the Ehrlich ascites tumour and mammalian liver. Biochim. Biophys. Acta 28 (1958) 376-385
37. Ropp P.A., and Traut T.W. Uridine kinase: altered enzyme with decreased affinities for uridine and CTP. Arch. Biochem. Biophys. 359 (1998) 63-68
38. Rozengurt E., Mierzejewski K., and Wigglesworth N. Uridine trasport and phosphorylation in mouse cells in culture: effect of growth-promoting factors, cell cycle transit and oncogenic transformation. J. Cell. Physiol. 97 (1978) 241-251
39. Shambaugh G.E. Pyrimidine biosynthesis. Am. J. Clin. Nutr. 32 (1979) 1290-1297
40. Suzuki N.N., Koizumi K., Fukushima M., Matsuda A., and Inagaki F. Structural basis for the specificity, catalysis, and regulation of human uridine-cytidine kinase. Structure 12 (2004) 751-764
41. Traut T.W. Physiological concentrations of purines and pyrimidines. Mol. Cell. Biochem. 140 (1994) 1-22
42. Traut T.W., and Jones M.E. Uracil metabolism-UMP synthesis from orotic acid or uridine and conversion of uracil to beta-alanine: enzymes and cDNAs. Prog. Nucleic Acid Res. Mol. Biol. 53 (1996) 1-78
43. Van Rompay A.R., Norda A., Johansson M., and Karlsson A. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Mol. Pharmacol. 59 (2001) 1181-1186
44. Wice B.M., and Kennel D. Ribose-1-P is the essential precursor for nucleic acid synthesis in animal cells growing on uridine in the absence of sugar. J. Biol. Chem. 257 (1982) 2578-2583
45. Wu X., Gutierrez M.M., and Giacomini K.M. Further characterization of the sodium-dependent nucleoside transporter (N3) in choroid plexus from rabbit. Biochim. Biophys. Acta 1191 (1994) 190-196