A rapid and simple high-performance liquid chromatography method for the determination of human plasma levofloxacin concentration and its application to bioequivalence studies

Biomedical Chromatography

Volumn 21, Issue 10, 2007, Pages 1045-1051

  Zhou, Zhi Ling ^a   Yang, Min ^a   Yu, Xi Yong ^a   Peng, Huai Yan ^b   Shan, Zhi Xin ^a   Chen, Shu Zhen ^a   Lin, Qiu Xiong ^a   Liu, Xiao Ying ^a   Chen, Tie Feng ^a   Zhou, Shu Feng ^c   Lin, Shu Guang ^a  

^a GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

Author keywords

Bioequivalence; HPLC FLD; Levofloxacin; Pharmacokinetics

Indexed keywords

FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PLASMA (HUMAN);

BIOEQUIVALENCE; BIOEQUIVALENCE STUDY; BUFFER PH; FLUORESCENCE DETECTION; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD WITH FLUORESCENCE DETECTION; HUMAN PLASMAS; LEVOFLOXACIN; MOBILE PHASIS; PHOSPHATE BUFFERS;

PHARMACOKINETICS;

ACETONITRILE; LEVOFLOXACIN; PHOSPHATE BUFFERED SALINE; TERAZOSIN; TRIETHYLAMINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CALIBRATION; CLINICAL TRIAL; COLUMN CHROMATOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG DOSAGE FORM COMPARISON; DRUG HALF LIFE; DRUG RETENTION; DRUG STRUCTURE; FLUORESCENCE ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; RANDOMIZED CONTROLLED TRIAL; RELIABILITY; SENSITIVITY AND SPECIFICITY; SINGLE DRUG DOSE; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 34848823438     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.851     Document Type: Article

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