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Emerging data on IMiDs in the treatment of myelodysplastic syndromes (MDS)
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List AF. Emerging data on IMiDs in the treatment of myelodysplastic syndromes (MDS). Semin Oncol 2005; 32 (4 Suppl 5):S31-S35.
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List AF. Advances in the treatment of myelodysplastic syndromes: the emergence of immunomodulatory drugs. Haematologica 2006; 91 (Suppl 1):167-170. This article is an excellent review of the biological effects of the IMiDs, as well as the clinical evidence supporting their use in MDS. The author helped develop lenalidomide as an effective treatment for MDS.
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List AF. Advances in the treatment of myelodysplastic syndromes: the emergence of immunomodulatory drugs. Haematologica 2006; 91 (Suppl 1):167-170. This article is an excellent review of the biological effects of the IMiDs, as well as the clinical evidence supporting their use in MDS. The author helped develop lenalidomide as an effective treatment for MDS.
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33749523024
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Immunomodulatory drugs (IMiDs): A new treatment option for myelodysplastic syndromes
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This is a comprehensive review of the biology and clinical trial data on IMiDs in the treatment of MDS
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Kale V, List AF. Immunomodulatory drugs (IMiDs): a new treatment option for myelodysplastic syndromes. Curr Pharm Biotechnol 2006; 7:339-342. This is a comprehensive review of the biology and clinical trial data on IMiDs in the treatment of MDS.
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Curr Pharm Biotechnol
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Kale, V.1
List, A.F.2
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Immunomodulation by thalidomide and thalidomide analogues
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Corral LG, Kaplan G. Immunomodulation by thalidomide and thalidomide analogues. Ann Rheum Dis 1999; 58 (Suppl 1):I107-I113.
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Report of an international working group to standardize response criteria for myelodysplastic syndromes
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Cheson BD, Bennett JM, Kantarjian H, et al. Report of an international working group to standardize response criteria for myelodysplastic syndromes. Blood 2000; 96:3671-3674.
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Cheson, B.D.1
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Thalidomide produces transfusion independence in long-standing refractory anemias of patients with myelodysplastic syndromes
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Raza A, Meyer P, Dutt D, et al. Thalidomide produces transfusion independence in long-standing refractory anemias of patients with myelodysplastic syndromes. Blood 2001; 98:958-965.
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Raza, A.1
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Muller GW, Chen R, Huang S-Y, et al. Amino-substituted thalidomide analogs: Potent inhibitors of TNF-α production. Bioorg Med Chem Lett 1999; 9:1625-1630.
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Muller, G.W.1
Chen, R.2
Huang, S.-Y.3
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The evolution of thalidomide and its IMiD derivatives as anticancer agents
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Bartlett JB, Dredge K, Dalgleish AG. The evolution of thalidomide and its IMiD derivatives as anticancer agents. Nat Rev Cancer 2004; 4:314-344.
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Bartlett, J.B.1
Dredge, K.2
Dalgleish, A.G.3
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Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-α
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Corral LG, Haslett PA, Muller GW, et al. Differential cytokine modulation and T cell activation by two distinct classes of thalidomide analogues that are potent inhibitors of TNF-α. J Immunol 1999; 163:380-386.
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Corral, L.G.1
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Epling-Burnette PK, Bai F, Painter JS, et al. Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors. Blood 2007; 109:4816-4824. This paper describes reduced NK cytotoxicity in high risk MDS. IMiDs augment NK cell activity.
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Epling-Burnette PK, Bai F, Painter JS, et al. Reduced natural killer (NK) function associated with high-risk myelodysplastic syndrome (MDS) and reduced expression of activating NK receptors. Blood 2007; 109:4816-4824. This paper describes reduced NK cytotoxicity in high risk MDS. IMiDs augment NK cell activity.
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1042301002
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Thalidomide therapy for myelodysplastic syndromes: Current status and future perspectives
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Musto P. Thalidomide therapy for myelodysplastic syndromes: Current status and future perspectives. Leuk Res 2004; 28:325-332.
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Musto, P.1
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Lenalidomide (CC-5013; Revlimid) promotes erythropoiesis in myelodysplastic syndromes (MDS) by CD45 protein tyrosine phosphatase (PTP) inhibition [abstract]
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List AF, Estes M, Williams A, et al. Lenalidomide (CC-5013; Revlimid) promotes erythropoiesis in myelodysplastic syndromes (MDS) by CD45 protein tyrosine phosphatase (PTP) inhibition [abstract]. Blood 2006; 108:397a.
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List, A.F.1
Estes, M.2
Williams, A.3
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Novel thalidomide analogues display antiangiogenic activity independently of immunomodulatory effects
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Dredge K, Marriott J, Macdonald C, et al. Novel thalidomide analogues display antiangiogenic activity independently of immunomodulatory effects. Br J Cancer 2002; 87:1166-1172.
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Dredge, K.1
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The immunomodulatory thalidomide analog, CC5013, inhibits trophic response in VEGF in AML cells by abolishing cytokine-induced P13/Akt activation
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List A, Tate W, Glinsmann-Gibson B. The immunomodulatory thalidomide analog, CC5013, inhibits trophic response in VEGF in AML cells by abolishing cytokine-induced P13/Akt activation. Blood 2002; 100:139.
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List, A.1
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Thalidomide and the immune system. 3. Simultaneous up- and down-regulation of different integrin receptors on human white blood cells
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Antiproliferative activity of CC-5013 in 5q- myelodysplastic syndrome (MDS) and acute lymphocytic lymphoma (ALL) cell lines [abstract]
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Gandhi AK, Naziruddin S, Verhelle D, et al. Antiproliferative activity of CC-5013 in 5q- myelodysplastic syndrome (MDS) and acute lymphocytic lymphoma (ALL) cell lines [abstract]. J Clin Oncol 2004; 22 (Suppl 14S):587s.
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Gandhi, A.K.1
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List A, Baker AF, Green S, Bellamy W. Lenalidomide: targeted anemia therapy for myelodysplastic syndrome. Cancer Control 2006; 13 (Suppl.):4-11. This paper describes the increased marrow apoptotic index resulting from lenalidomide therapy in MDS patients with deletion 5q and reduction in the marrow proliferative index in nondeletion 5q responders.
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List A, Baker AF, Green S, Bellamy W. Lenalidomide: targeted anemia therapy for myelodysplastic syndrome. Cancer Control 2006; 13 (Suppl.):4-11. This paper describes the increased marrow apoptotic index resulting from lenalidomide therapy in MDS patients with deletion 5q and reduction in the marrow proliferative index in nondeletion 5q responders.
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Efficacy of lenalidomide in myelodysplastic syndromes
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List A, Kurtin S, Roe D, et al. Efficacy of lenalidomide in myelodysplastic syndromes. N Engl J Med 2005; 352:11-19.
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List A, Dewald G, Bennett J, et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med 2006; 355:38-47. This landmark study evaluated lenalidomide treatment for MDS patients with deletion 5q. High rates of transfusion independence and durable responses are described.
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List A, Dewald G, Bennett J, et al. Lenalidomide in the myelodysplastic syndrome with chromosome 5q deletion. N Engl J Med 2006; 355:38-47. This landmark study evaluated lenalidomide treatment for MDS patients with deletion 5q. High rates of transfusion independence and durable responses are described.
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23744513172
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Incidence and prognostic significance of karyotype abnormalities in de novo primary myelodysplastic syndromes: A study on 331 patients from a single institution
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Bernasconi P, Klersy C, Boni M, et al. Incidence and prognostic significance of karyotype abnormalities in de novo primary myelodysplastic syndromes: a study on 331 patients from a single institution. Leukemia 2005; 19:1424-1431.
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Results of the MDS-002 and -003 international phase II studies evaluating lenalidomide (CC-5013, Revlimid®) in the treatment of transfusion-dependent patients with myelodysplastic syndrome (MDS)
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List AF, Dewald G, Bennett J, et al. Results of the MDS-002 and -003 international phase II studies evaluating lenalidomide (CC-5013, Revlimid®) in the treatment of transfusion-dependent patients with myelodysplastic syndrome (MDS). Haematologica 2005; 90 (Suppl 2):307a.
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Kurtin S, Sokol L. Practical considerations in the use of lenalidomide therapy for myelodysplastic syndromes. Cancer Control 2006; 13 (Suppl):26-31. This article describes the clinical implications of the data regarding lenalidomide therapy for lower risk MDS.
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Kurtin S, Sokol L. Practical considerations in the use of lenalidomide therapy for myelodysplastic syndromes. Cancer Control 2006; 13 (Suppl):26-31. This article describes the clinical implications of the data regarding lenalidomide therapy for lower risk MDS.
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