Relationship between aryl hydrocarbon receptor-affinity and the induction of EROD activity by 2,3,7,8-tetrachlorinated phenothiazine and derivatives

Toxicology and Applied Pharmacology

Volumn 224, Issue 2, 2007, Pages 147-155

  Fried, Kristian W ^a   Bazzi, Rana ^b   Levy Lopez, Walkiria ^c   Corsten, Claudia ^c   Schramm, Karl Werner ^c   Bell, David R ^b   Rozman, Karl K ^a,c  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Aryl hydrocarbon receptor (AhR); CYP1A1; EROD; Tetrachlorodibenzo p dioxin (TCDD); Tetrachlorophenothiazine (TCPT)

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 2,3,7,8 TETRACHLOROPHENOTHIAZINE; 2,3,7,8 TETRACHLOROPHENOTHIAZINE SULFOXIDE; 2,3,7,8 TETRACHLOROPHENYLPHENOTHIAZINE SULFONE; AROMATIC HYDROCARBON RECEPTOR; ETHOXYRESORUFIN DEETHYLASE; LIGAND; N METHYL 2,3,7,8 TETRACHLOROPHENYLPHENOTHIAZINE; N METHYL 2,3,7,8 TETRACHLOROPHENYLPHENOTHIAZINE SULFONE; PHENOTHIAZINE DERIVATIVE; SULFONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INDUCTION; IN VITRO STUDY; LIVER CYTOSOL; METHYLATION; NONHUMAN; OXIDATION; QUANTITATIVE ANALYSIS; RAT; RECEPTOR AFFINITY;

ANIMALS; BINDING, COMPETITIVE; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INDUCTION; LIGANDS; PHENOTHIAZINES; RATS; RECEPTORS, ARYL HYDROCARBON; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

RATTUS;

EID: 34848815316     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2007.06.026     Document Type: Article

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