Hormone therapy in menopausal women with cognitive complaints: A randomized, double-blind trial

Neurology

Volumn 69, Issue 13, 2007, Pages 1322-1330

  Maki, P M ^a   Gast, M J ^b,d   Vieweg, A J ^b   Burriss, S W ^b   Yaffe, K ^c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b PFIZER INC   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONJUGATED ESTROGEN PLUS MEDROXYPROGESTERONE ACETATE;

ABDOMINAL PAIN; ADULT; ARTHRALGIA; ARTICLE; BACKACHE; BREAST TENDERNESS; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG INDUCED HEADACHE; DYSPEPSIA; FEMALE; HORMONAL THERAPY; HUMAN; MEDICAL ASSESSMENT; MENOPAUSAL SYNDROME; MUSCLE CRAMP; OUTCOME ASSESSMENT; PHARYNGITIS; POSTMENOPAUSE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; SAMPLE SIZE; SEXUAL BEHAVIOR; SINUSITIS; THERAPY EFFECT; TOOTH PAIN; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; VASOMOTOR DISORDER; VERBAL MEMORY; WOMEN'S HEALTH;

COGNITION DISORDERS; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; ESTROGEN REPLACEMENT THERAPY; ESTROGENS; FEMALE; GONADAL STEROID HORMONES; HUMANS; MEDROXYPROGESTERONE 17-ACETATE; MEMORY; MEMORY DISORDERS; MENOPAUSE; MIDDLE AGED; NEUROPROTECTIVE AGENTS; NEUROPSYCHOLOGICAL TESTS; PLACEBOS; TREATMENT FAILURE;

EID: 34748925938     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/01.wnl.0000277275.42504.93     Document Type: Article

References (48)

1. Gold EB, Sternfeld B, Kelsey JL, et al. Relation of demographic and lifestyle factors to symptoms in a multiracial/ethnic population of women 40-55 years of age. Am J Epidemiol 2000;152:463-473.
2. Shaywitz SE, Naftolin F, Zelterman D, et al. Better oral reading and short-term memory in midlife, postmenopausal women taking estrogen. Menopause 2003;10:420-426.
3. Vanhulle G, Demol R. A double-blind study into the influence of estriol on a number of psychological tests in post-menopausal women. In: van Keep PA, Greenblatt RB, Albeaux-Fernet M, eds. Consensus on the Menopause Research. London: MTP Press, 1976: 94-99.
4. Hackman BW, Galbraith D. Replacement therapy and piperazine oestrone sulphate (Harmogen) and its effect on memory. Curr Med Res Opin 1976;4:303-306.
5. Fedor-Freybergh P. The influence of oestrogens on the wellbeing and mental performance in climacteric and postmenopausal women. Acta Obstet Gynecol Scand 1977;64:1-91.
6. Sherwin BB. Affective changes with estrogen and androgen replacement therapy in surgically menopausal women. J Affect Disord 1988;14:177-187.
7. Phillips SM, Sherwin BB. Effects of estrogen on memory function in surgically menopausal women. Psychoneuroendocrinology 1992;17:485-495.
8. Espeland M, Rapp S, Shumaker S, et al. Conjugated equine estrogens and global cognitive function in postmenopausal women: Women's Health Initiative Memory Study. JAMA 2004;291:2959-2968.
9. Shumaker S, Legault C, Rapp S, et al. Estrogen plus progestin and the incidence of dementia and mild cognitive impairment in postmenopausal women: The Women's Health Initiative Memory Study: a randomized controlled trial. JAMA 2003;289:2651-2662.
10. Shumaker S, Legault C, Kuller L, et al. Conjugated equine estrogens and incidence of probable dementia and mild cognitive impairment in postmenopausal women: Women's Health Initiative Memory Study. JAMA 2004;291:2947-2958.
11. Zandi PP, Carlson MC, Plassman BL, et al. Hormone replacement therapy and incidence of Alzheimer's disease in older women: The Cache County Study. JAMA 2002;288:2123-2129.
12. Silva I, Mello LE, Freymuller E, Haidar MA, Baracat EC. Onset of estrogen replacement has a critical effect on synaptic density of CA1 hippocampus in ovariectomized adult rats. Menopause 2003;10:406-411.
13. Linzmayer L, Semlitsch HV, Saletu B, et al. Double-blind, placebo-controlled psychometric studies on the effects of a combined estrogen-progestin regimen versus estrogen alone on performance, mood and personality of menopausal syndrome patients. Arzneimittelforschung 2001;51:238-245.
14. Delis DC, Kramer JH, Kaplan E, Ober BA. California Verbal Learning Test, Research Edition. New York: The Psychological Corporation, 1987.
15. Delis D, Kramer J, Kaplan E, Ober B. California Verbal Learning Test. Adult Version Manual, second edition. San Antonio, TX: Psychological Corporation, Harcourt-Brace, 2000.
16. Zelinski EM, Gilewski MJ, Anthony-Bergstone CR. Memory Functioning Questionnaire: Concurrent validity with memory performance and self-reported memory failures. Psychol Aging 1990;5:388-399.
17. Schretlen D, Bobholz JH, Brandt J. Development and psychometric properties of the Brief Test of Attention. Clin Neuropsychol 1996;10:80-89.
18. Benton AL. Differential behavioral effects in frontal lobe disease. Neuropsychologia 1968;6:53-60.
19. Ekstrom RB, French JW, Harman HH. Manual for Kit of Factor-Referenced Cognitive Tests. Princeton, NJ: Educational Testing Service, 1976.
20. Wechsler D. Manual for the Wechsler Memory Scale Revised. San Antonio, TX: Psychological Corporation, 1987.
21. Watson D, Clark L, Tellegen A. Development and validation of brief measures of positive and negative affect: The PANAS scales. J Pers Soc Psychol 1988;54:1062-1070.
22. Greene JG. Constructing a standard climacteric scale. Maturitas 1998;29:25-31.
23. Utian W, Janata J, Kingsberg S, Schluchter M, Hamilton J. The Utian Quality of Life (UQOL) Scale: development and validation of an instrument to quantify quality of life through and beyond menopause. Menopause 2002;9:402-410.
24. Buysse DJ, Reynolds CF,3rd Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res 1989;28:193-213.
25. Chlebowski RT, Hendrix SL, Langer RD, et al. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: the Women's Health Initiative Randomized Trial. JAMA 2003;289:3243-3253.
26. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321-333.
27. Grady D, Yaffe K, Kristof M, Lin F, Richards C, Barrett-Connor E. Effect of postmenopausal hormone therapy on cognitive function: the Heart and Estrogen/progestin Replacement Study. Am J Med 2002;113:543-548.
28. Resnick SM, Maki PM, Rapp SR, et al. Effects of combination estrogen plus progestin hormone treatment on cognition and affect. J Clin Endocrinol Metab 2006;91:1802-1810.
29. Viscoli CM, Brass LM, Kernan WN, Sarrel PM, Suissa S, Horwitz RI. Estrogen therapy and risk of cognitive decline: results from the Women's Estrogen for Stroke Trial (WEST). Am J Obstet Gynecol 2005;192:387-393.
30. Yaffe K, Vittinghoff E, Ensrud KE, et al. Effects of ultra-low-dose transdermal estradiol on cognition and health-related quality of life. Arch Neurol 2006;63:945-950.
31. Maki PM, Resnick SM. Longitudinal effects of estrogen replacement therapy on PET cerebral blood flow and cognition. Neurobiol Aging 2000;21:373-383.
32. Effects of hormone replacement therapy on endometrial histology in postmenopausal women. The Postmenopausal Estrogen/Progestin Interventions (PEPI) Trial. The Writing Group for the PEPI Trial. JAMA 1996;275:370-375.
33. Nilsen J, Brinton RD. Divergent impact of progesterone and medroxyprogesterone acetate (Provera) on nuclear mitogen-activated protein kinase signaling. Proc Natl Acad Sci USA 2003;100:10506-10511.
34. Nilsen J, Brinton RD. Impact of progestins on estradiol-potentiation of the glutamate calcium response. Neuroreport 2002;13:825-830.
35. Rosario ER, Ramsden M, Pike CJ. Progestins inhibit the neuroprotective effects of estrogen in rat hippocampus. Brain Res 2006;1099:206-210.
36. Smith YR, Giordani B, Lajiness-O'Neill R, Zubieta JK. Long-term estrogen replacement is associated with improved nonverbal memory and attentional measures in postmenopausal women. Fertil Steril 2001;76:1101-1107.
37. Resnick SM, Metter EJ, Zonderman AB. Estrogen replacement therapy and longitudinal decline in visual memory: a possible protective effect? Neurology 1997;49:1491-1497.
38. Bagger YZ, Tanko LB, Alexandersen P, Qin G, Christiansen C. Early postmenopausal hormone therapy may prevent cognitive impairment later in life. Menopause 2005;12:12-17.
39. Kawas C, Resnick S, Morrison A, et al. A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging. Neurology 1997;48:1517-1521.
40. Tang M-X, Jacobs D, Stern Y, et al. Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease. Lancet 1996;348:429-432.
41. Mulnard RA, Cotman CW, Kawas C, et al. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. JAMA 2000;283:1007-1015.
42. Sherwin BB. Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women. Psychoneuroendocrinology 1988;13:345-357.
43. Ditkoff EC, Crary WG, Cristo M, Lobo RA. Estrogen improves psychological function in asymptomatic postmenopausal women. Obstet Gynecol 1991;78:991-995.
44. Daniel JM, Hulst JL, Berbling JL. Estradiol replacement enhances working memory in middle-aged rats when initiated immediately after ovariectomy but not after a long-term period of ovarian hormone deprivation. Endocrinology 2006;147:607-614.
45. Gibbs RB. Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats. Neurobiol Aging 2000;21:107-116.
46. Gibbs RB. Estrogen replacement enhances acquisition of a spatial memory task and reduces deficits associated with hippocampal muscarinic receptor inhibition. Horm Behav 1999;36:222-233.
47. Savonenko AV, Markowska AL. The cognitive effects of ovariectomy and estrogen replacement are modulated by aging. Neuroscience 2003;119:821-830.
48. Dennerstein L, Dudley E, Burger H. Are changes in sexual functioning during midlife due to aging or menopause? Fertil Steril 2001;76:456-460.