Process patent protection: Characterizing synthetic pathways by stable-isotopic measurements

Pharmaceutical Technology

Volumn 31, Issue 3, 2007, Pages 68-78

  Jasper, John P ^a   Weaner, Larry E ^b   Hayes, John M ^c  

^a Molecular Isotope Technologies LLC   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c WOODS HOLE OCEANOGRAPHIC INSTITUTION   (United States)

Author keywords

Isotope fractionation; PAC; Process analytical chemistry; Process patent protection; Stable isotopes; Synthesis

Indexed keywords

ISOTOPES; PROCESS ENGINEERING; PRODUCT DEVELOPMENT; SYNTHESIS (CHEMICAL);

ISOTOPE FRACTIONATION; PROCESS ANALYTICAL CHEMISTRY; PROCESS PATENT PROTECTION; STABLE ISOTOPES;

FRACTIONATION;

CARBON 13; DEUTERIUM; ISOTOPE; NITROGEN 15; OXYGEN 18; SULFUR;

DRUG INDUSTRY; FORENSIC IDENTIFICATION; ISOTOPE LABELING; PATENT; PROCESS CONTROL; PROCESS MONITORING; REVIEW;

EID: 34748914804     PISSN: 15432521     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (14)

1. J.P. Jasper, "Pharmaceutical Security: Using Stable Isotopes to Authenticate Pharmaceutical Materials," Tablets and Capsules 2 (3), 37-42 (2004).
2. J.P. Jasper, R.C. Lyon, and L.E. Weaner, "Stable Isotopes Provide a New PAT [Process Analytical Technology] Tool," Pharm. Mfg. 4 (5), 28-33 (2005).
3. J.P. Jasper et al., "Stable Isotopic Characterization of Analgesic Drugs," Pharm. Technol. 28 (8), 60-67 (2004).
4. J.P. Jasper et al., "Stable Isotopic Characterization of Active Pharmaceutical Ingredients," J. Pharm. Biomed. Anal. 35, 21-30 (2004).
5. A.M. Wokovich et al., "Stable Isotopic Composition of the Active Pharmaceutical Ingredient (API) Naproxen," Pharm. Biomed. Anal. 38, 781-784 (2005).
6. A. Schimmelman, M.D. Lewan, and R.P. Wintsch, "D/H Isotope Ratios of Kerogen, Bitumen, Oil, and Water in Hydrous Pyrolysis of Source Rocks Containing Type-I, -II, -IIS, and -III kerogen," Geochim. Comsochim. Acta 63 (22), 3751-3766 (1999).
7. L.I. Wassenaar and K.A. Hobson, "Improved Method for Determining the Stable-Hydrogen Isotopic Composition (SD) of Complex Organic Materials of Environmental Interest," Environ. Sci. Technol. 34, 2354-2360 (2000).
8. P.E. Sauer et al., "Compound-Specific D/H Ratios of Lipid Biomarkers from Sediments as a Proxy for Environmental and Climatic Conditions," Geochim. Comsochim. Acta 65 (2), 213-222 (2001).
9. 13C Analyses of n- Alkanes Extracted from Terrestrial and Aquatic Plants," Phytochem. 63, 361-371 (2003).
10. J.M. Hayes, "An Introduction to Isotopic Calculations," (National Ocean Sciences Accelerator Mass Spectrometry Facility, Woods Hole, MA, 2004), http://www.nosams.whoi.edu/docs/IsoCalcs.pdf accessed Jan. 22, 2007.
11. J.P. Jasper, "The Increasing Use of Stable Isotopes in the Pharmaceutical Industry," Pharm. Technol. 23 (10), 106-114 (1999).
12. J.M. Hayes, "Practice and Principles of Isotopic Measurements in Organic Geochemistry," (National Ocean Sciences Accelerator Mass Spectrometry Facility, Woods Hole, MA, 2002), http://www.nosams.whoi.edu/docs/ IsoNotesAug02.pdf, accessed Jan. 22, 2007.
13. J.P. Jasper, "Quantitative Estimates of Precision for Molecular Isotopic Measurements," Rap. Comm. Mass Spec., 15, 1554-1557 (2001).
14. K.M. Scott et al., "Optimal Methods for Estimating Kinetic Isotope Effects from Different Forms of the Rayleigh Distillation Equation," Geochim. Cosmochim. Acta, 68 (3), 433-442 (2004).