High-resolution magic-angle spinning NMR for the identification of reaction products directly from thin-layer chromatography spots

Magnetic Resonance in Chemistry

Volumn 45, Issue 10, 2007, Pages 814-818

  Bradley, Scott A ^a,b   McLaughlin, Rebekah L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

HRMAS; Magic angle spinning; Nano probe; NMR; Thin layer chromatography; TLC

Indexed keywords

MAGIC ANGLE SPINNING; REACTION PRODUCTS; THIN LAYER CHROMATOGRAPHY;

BACKGROUND SIGNALS; HIGH RESOLUTION MAGIC ANGLE SPINNING; HIGH-RESOLUTION MAGIC ANGLE SPINNING NMR; MAGIC-ANGLE SPINNING; NANO PROBES; ORGANIC REACTION; SPECTRA'S; STATIONARY PHASE; THIN-LAYER CHROMATOGRAPHY;

SIGNAL TO NOISE RATIO;

EID: 34748891668     PISSN: 07491581     EISSN: 1097458X     Source Type: Journal    
DOI: 10.1002/mrc.2040     Document Type: Article

References (18)

1. Cheng LL, Ma MJ, Becerra L, Ptak T, Tracey I, Lackner A, Gonzalez RG. Proc. Natl. Acad. Sci. 1997; 94: 6408.
2. Power WP. Annu. Rep. NMR Spectrosc. 2003; 51: 261.
3. Griffin JL, Nicholson JK, Holmes E, Lindon JC. In Metabonomics in Toxicity Assessment, Robertson DG, Lindon JC (eds). Taylor & Francis Group: Boca Raton, 2005; 173.
4. Simpson AJ, Kingery WL, Shaw DR, Spraul M, Humpfer E, Dvortsak P. Environ. Sci. Technol. 2001; 35: 3321.
5. Delort AM. Environ. Chem. Lett. 2004; 1: 209.
6. Weybright P, Mills K, Campbell N, Cory DG, Singer S. Magn. Reson. Med. 1998; 39: 337.
7. Li W. Analyst 2006; 131: 777.
8. Fitch WL, Detre G, Holmes CP, Shoolery JN, Keifer PA. J. Org. Chem. 1994; 59: 7955.
9. Handel H, Gesele E, Gottschall K, Albert K. Angew. Chem. Int. Ed. 2003; 42: 438.
10. Hellriegel C, Skogsberg U, Albert K, Lammerhofer M, Maier NM, Lindner W. J. Am. Chem. Soc. 2004; 126: 3809.
11. Coen M, Wilson ID, Nicholson JK, Tang H, Lindon JC. Anal. Chem. 2004; 76: 3023.
12. Wilson ID, Spraul M, Humpfer E. J. Planar Chromatogr. - Mod. TLC 1997; 10: 217.
13. Barbara TM. J. Magn. Reson. A 1994; 109: 265.
14. Fried B, Sherma J. Thin-Layer Chromatography. Marcel Dekker: New York, 1999.
15. Viel S, Ziarelli F, Caldarelli S. Proc. Natl. Acad. Sci. 2003; 100: 9696.
16. Carr HY, Purcell EM. Phys. Rev. 1954; 94: 630.
17. Meiboom S, Gill D. Rev. Sci. Instrum. 1958; 29: 688.
18. Rabenstein DL. J. Biochem. Biophys. Methods 1984; 9: 277.