Effect of prenatal exposure to diclofenac sodium on Purkinje cell numbers in rat cerebellum: A stereological study

Brain Research

Volumn 1174, Issue 1, 2007, Pages 130-135

  Ragbetli, Murat Cetin ^a   Ozyurt, Birsen ^b   Aslan, Huseyin ^b   Odaci, Ersan ^c   Gokcimen, Alpaslan ^d   Sahin, Bunyamin ^e   Kaplan, Suleyman ^f  

^a YUZUNCU YIL UNIVERSITY   (Turkey)

^b GAZIOSMANPASA UNIVERSITY   (Turkey)

^c KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

^d SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^e ONDOKUZ MAYIS UNIVERSITY   (Turkey)

^f ONDOKUZ MAYIS UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

Author keywords

Cerebellum; Diclofenac sodium; Male; Non steroidal anti inflammatory drug; Purkinje cell; Rat; Stereology

Indexed keywords

DICLOFENAC;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL COUNT; CEREBELLUM; CONTROLLED STUDY; DELIVERY; DRUG EFFECT; FEMALE; HISTOPATHOLOGY; MALE; NEWBORN; NONHUMAN; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGENY; PURKINJE CELL; RAT; STEREOMETRY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL COUNT; CEREBELLUM; DICLOFENAC; FEMALE; MALE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PURKINJE CELLS; RATS; RATS, INBRED STRAINS;

ANIMALIA; RATTUS;

EID: 34748880812     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.08.025     Document Type: Article

References (40)

1. Altman J. Postnatal development of the cerebellar cortex in the rat: I. The external germinal layer and the transitional molecular layer. J. Comp. Neurol. 145 (1972) 353-397
2. Altman J. Postnatal development of the cerebellar cortex in the rat: II. Phases in the maturation of Purkinje cells and of the molecular layer. J. Comp. Neurol. 145 (1972) 399-463
3. Altman J. Postnatal development of the cerebellar cortex in the rat: 3. Maturation of the components of the granular layer. J. Comp. Neurol. 145 (1972) 465-513
4. Andersohn F., Suissa S., and Garbe E. Use of first- and second-generation cyclooxygenase-2-selective nonsteroidal antiinflammatory drugs and risk of acute myocardial infarction. Circulation 113 (2006) 1950-1957
5. Beck A., Krischak G., Sorg T., Augat P., Farker K., Merkel U., Kinzl L., and Claes L. Influence of diclofenac (group of nonsteroidal anti-inflammatory drugs) on fracture healing. Arch. Orthop. Trauma Surg. 123 (2003) 327-332
6. Capone M.L., Tacconelli S., Di Francesco L., Sacchetti A., Sciulli M.G., and Patrignani P. Pharmacodynamic of cyclooxygenase inhibitors in humans. Prostaglandins Other Lipid Mediat. 82 (2007) 85-94
7. Carp H.J., Fein A., and Nebel L. Effect of diclofenac on implantation and embryonic development in the rat. Eur. J. Obstet. Gynecol. Reprod. Biol. 28 (1988) 273-277
8. Chan L.Y., Chiu P.Y., Siu S.S., and Lau T.K. A study of diclofenac-induced teratogenicity during organogenesis using a whole rat embryo culture model. Hum. Reprod. 16 (2001) 2390-2393
9. Chang J.K.., Wang GJ., Tsai S.T., and Ho M.L. Nonsteroidal anti-inflammatory drug effects on osteoblastic cell cycle, cytotoxicity, and cell death. Connect. Tissue Res. 46 (2005) 200-210
10. Chen L.C., and Ashcroft D.M. Do selective COX-2 inhibitors increase the risk of cerebrovascular events? A meta-analysis of randomized controlled trials. J. Clin. Pharm. Ther. 31 (2006) 565-576
11. Chen W.J., and Harle L.K. Interactive effect of alcohol and nicotine on developing cerebellum: an investigation of the temporal pattern of alcohol and nicotine administration. Alcohol. Clin. Exp. Res. 29 (2005) 437-442
12. Gokcimen A., Ragbetli M.C., Bas O., Tunc A.T., Aslan H., Yazici A.C., and Kaplan S. Effect of prenatal exposure to an anti-inflammatory drug on neuron number in cornu ammonis and dentate gyrus of the rat hippocampus: a stereological study. Brain Res. 1127 (2007) 185-192
13. Goodlett C.R., Pearlman A.D., and Lundahl K.R. Binge neonatal alcohol intubations induce dose-dependent loss of Purkinje cells. Neurotoxicol. Teratol. 20 (1998) 285-292
14. Gundersen H.J.G. Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones in memory of William R Thomson. J. Microsc. 143 (1986) 3-45
15. Gundersen H.J.G., and Jensen E.B. The efficacy of systematic sampling in stereology and its prediction. J. Microsc. 147 (1987) 229-263
16. Helsley S., Dlugos C.A., Pentney R.J., Rabin R.A., and Winter J.C. Effects of chronic ibogaine treatment on cerebellar Purkinje cells in the rat. Brain Res. 759 (1997) 306-308
17. Ito M. The modifiable neuronal network of the cerebellum. Jpn. J. Physiol. 34 (1984) 781-792
18. Koppel H., and Lewis P.D. Cell proliferation and DNA-synthesis in the external granular layer of the postnatal rat cerebellum: a quantitative study. Neuropathol. Appl. Neurobiol. 9 (1983) 207-214
19. Kudo C., Wada K., Masuda T., Yonemura T., Shibuya A., Fujimoto Y., Nakajima A., Niwa H., and Kamisaki Y. Diclofenac inhibits proliferation and differentiation of neural stem cells. Biochem. Pharmacol. 66 (2003) 289-295
20. Lafarga M., Berciano M.T., and Blanco M. Ectopic Purkinje cells in the cerebellar white matter of normal adult rodents: a Golgi study. Acta Anat. 127 (1986) 53-58
21. Lee C., Kim D.W., Jeon G.S., Roh E.J., Seo J.H., Wang K.C., and Cho S.S. Cerebellar alterations induced by chronic hypoxia: an immunohistochemical study using a chick embryonic model. Brain Res. 901 (2001) 271-276
22. Li H.P., Miki T., Gu H., Satriotomo I., Mastumoto Y., Kuma H., Gonzalez D., Bedi K.S., Suwaki H., and Takeuchi Y. The effect of the timing of prenatal X-irradiation on Purkinje cell numbers in rat cerebellum. Dev. Brain Res. 139 (2002) 159-166
23. + current in rat cerebellar granule cells. Neuropharmacology 48 (2005) 918-926
24. Mancini L., Bertossi M., and Roncalli L. Differentiation of cerebellar Purkinje neurons of the normal and chronically hypoxic chick embryo. Boll. Soc. Ital. Sper. 61 (1985) 79-85
25. Miki T., Harris S., Wilce P., Takeuchi Y., and Bedi K.S. The effect of the timing of ethanol exposure during early postnatal life on total number of Purkinje cells in rat cerebellum. J. Anat. 194 (1999) 423-431
26. Odaci E., Kaplan S., Sahin B., Bas O., Gevrek F., Aygun D., Unal B., Sonmez O.F., Colakoglu S., and Bilgic S. Effects of low-dose oxcarbazepine administration on developing cerebellum in newborn rat: a stereological study. Neurosci. Res. Commun. 34 (2004) 28-36
27. Raetzman L.T., and Siegel R.E. Immature granule neurons from cerebella of different ages exhibit distinct developmental potentials. J. Neurobiol. 38 (1999) 559-570
28. Russell R.I. Non-steroidal anti-inflammatory drugs and gastrointestinal damage-problems and solutions. Postgrad. Med. J. 77 (2001) 82-88
29. Savaser A., Ozkan Y., and Isimer A. Preparation and in vitro evaluation of sustained release tablet formulations of diclofenac sodium. Farmaco 60 (2005) 171-177
30. Scholer D.W., Ku E.C., Boettcher I., and Schweizer A. Pharmacology of diclofenac sodium. Am. J. Med. 80 (1986) 34-38
31. Siu K.L., and Lee W.H. Maternal diclofenac sodium ingestion and severe neonatal pulmonary hypertension. J. Paediatr. Child Health 40 (2004) 152-153
32. Siu S.S.N., Yeung J.H.K., and Lau T.K. Study on placental transfer of diclofenac in first trimester of human pregnancy. Hum. Reprod. 15 (2000) 2423-2425
33. Sørensen F.W., Larsen J.O., Eide R., and Schiønning J.D. Neuron loss in cerebellar cortex of rats exposed to mercury vapor: a stereological study. Acta Neuropathol. (Berl) 100 (2000) 95-100
34. Sotelo C. Cellular and genetic regulation of the development of the cerebellar system. Prog. Neurobiol. 72 (2004) 295-339
35. Tunc A.T., Turgut M., Aslan H., Sahin B., Yurtseven M.E., and Kaplan S. Neonatal pinealectomy induces Purkinje cell loss in the cerebellum of the chick: a stereological study. Brain Res. 1067 (2006) 95-102
36. Tunc A.T., Aslan H., Turgut M., Ekici F., Odaci E., and Kaplan S. Inhibitory effect of pinealectomy on the development of cerebellar granule cells in the chick: a stereological study. Brain Res. 1138 (2007) 214-220
37. Unal B., Ozbek M.E., Aydin M.D., Aydin N., Bulucu Z., Vuraler O., Odaci E., Sahin B., and Kaplan S. Effect of haloperidol on the numerical density of neurons and nuclear height in the rat hippocampus - (a stereological and histopathological study). Neurosci. Res. Commun. 34 (2004) 1-9
38. Voogd J., and Glickstein M. The anatomy of the cerebellum. Trends Neurosci. 21 (1998) 370-375
39. West M.J., Slomianka L., and Gundersen H.J.G. Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat. Rec. 231 (1991) 482-497
40. Yacubova E., and Komuro H. Cellular and molecular mechanisms of cerebellar granule cell migration. Cell Biochem. Biophys. Rev. 37 (2003) 213-234