Interference with hemoglobin A1c determination by the hemoglobin variant shelby

American Journal of Clinical Pathology

Volumn 128, Issue 3, 2007, Pages 440-444

  Scuderi, Richard T ^a,b   Griffin, Terrance L ^b   Mehta, Shruti P ^b   Herold, David A ^a,b   Fitzgerald, Robert L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

Boronate affinity; Hemoglobin A1c; Hemoglobin Shelby; Hemoglobin variant; Hemoglobinopathy; High performance liquid chromatography; Mass spectrometry

Indexed keywords

ALPHA GLOBIN; BETA GLOBIN; HEMOGLOBIN A1C; HEMOGLOBIN SHELBY; HEMOGLOBIN VARIANT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD SMEAR; CASE REPORT; DNA SEQUENCE; GLUCOSE BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HEMOGLOBIN DETERMINATION; HEMOGLOBINOPATHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ION EXCHANGE CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL;

BLOOD GLUCOSE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, ION EXCHANGE; GLOBINS; HEMOGLOBIN A, GLYCOSYLATED; HEMOGLOBINOMETRY; HEMOGLOBINS, ABNORMAL; HUMANS; MALE; MASS SPECTROMETRY; MEDICAL ERRORS; MIDDLE AGED; MUTATION, MISSENSE;

EID: 34748873999     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/WPY5UHR424VUHG8A     Document Type: Article

References (20)

1. 1c, fasting glucose and BMI is effective in screening for individuals at risk of future type 2 diabetes: OGTT is not needed. J Intern Med. 2006;260:263-271.
2. 1c in the Diabetes Control and Complications Trial. Diabetes Care. 2002;25:275-278.
3. Klenk DC, Hermanson GT, Krohn RI, et al. Determination of glycosylated hemoglobin by affinity chromatography: comparison with colorimetric and ion-exchange methods, and effects of common interferences. Clin Chem. 1982;28:2088-2094.
4. Mallia AK, Hermanson GT, Krohn RI, et al. Preparation and use of a boronic acid support for separation and quantitation of glycosylated hemoglobins. Anal Lett. 1981;14:649-661.
5. Moo-Penn WF, Johnson MH, McGuffey JE, et al. Hemoglobin Shelby [beta 131(H9) Gln - Lys] a correction to the structure of hemoglobin Deaconess and hemoglobin Leslie. Hemoglobin. 1984;8:583-593.
6. Roberts WL, Frank EL, Moulton L, et al. Effects of nine hemoglobin variants on five glycohemoglobin methods. Clin Chem. 2000;46:569-572.
7. 1c). Diabetes Metab Res Rev. 2001;17:94-98.
8. Weykamp CW, Penders TJ, Muskiet FA, et al. Influence of hemoglobin variants and derivatives on glycohemoglobin detetminations, as investigated by 102 laboratories using 16 methods. Clin Chem. 1993;39:1717-1723.
9. Weykamp CW, Penders TJ, Siebelder CW, et al. Interference of carbamylated and acetylated hemoglobins in assays of glycohemoglobin by HPLC, electrophoresis, affinity chromatography, and enzyme immunoassay. Clin Chem. 1993;39:138-142.
10. 2 quantification by HPLC. Clin Chem. 1996;42:1113-1114.
11. Lutcher CL, Wilson JB, Gravely ME, et al. Hb Leslie, an unstable hemoglobin due to deletion of glutaminyl residue beta 131 (H9) occurring in association with beta0-thalassemia, HbC, and HbS. Blood. 1976;47:99-112.
12. Felice A, Abraham EC, Miller A, et al. Is the trimodality of Hb Leslie (alpha 2 beta 2 131 Gln - O) in heterozygotes the result of a variable number of active alpha-chain genes? evidence for posttranslational control of hemoglobin synthesis. Am J Hematol. 1978;5:1-9.
13. Carcassi UE, Pintus A. beta 0-Thalassemia in association with Hb Leslie (alpha 2 beta 2 131Gln leads to O) in a Satdinian family. Hemoglobin. 1980;4:195-200.
14. Curuk MA, Kutlar A, Huisman TH. Hb Shelby [alpha 2 beta 2(131)(H9)Gln - Lys]-beta zeto-thalassemia [codon 15 (TGG - TGA)] identified by DNA sequencing. Hemoglobin. 1992;16:417-419.
15. Joutovsky A, Hadzi-Nesic J, Nardi MA. HPLC retention time as a diagnostic tool for hemoglobin variants and hemoglobinopathies: a study of 60000 samples in a clinical diagnostic laboratory. Clin Chem. 2004;50:1736-1747.
16. Hoyer JD, Scheidt RM. Identification of hemoglobin variants by HPLC [letter]. Clin Chem. 2005;51:1303-1304.
17. Bio-Rad VARIANT Library of Abnormal Hemoglobins, Version 3.0. Abnormal Hemoglobin Candidates: An Aid to Interpretation.
18. Moo-Penn WF, Jue DL, Bechtel KC, et al. Hemoglobin Deaconess a new deletion mutant: beta131 (H9) glutamine deleted. Biochem Biophys Res Commun. 1975;65:8-15.
19. Adachi K, Surrey S, Tamary H, et al. Hb Shelby [beta 131(H9)Gln→Lys] in association with Hb S [beta 6(A3)Glu→Val]: characterization, stability, and effects on Hb S polymerization. Hemoglobin. 1993;17:329-343.
20. Wagner SC, Pereira C, Castro SM. Association of Hb Shelby with Hb S in the south of Brazil [letter]. Haematologica. 2006;91:1141-1142.