Artocarpus communis forst. Root-bark aqueous extract-and streptozotocin-induced ultrastructural and metabolic changes hepatic tissues of wistar rats

African Journal of Traditional, Complementary and Alternative Medicines

Volumn 4, Issue 4, 2007, Pages 397-410

  Adewole, Stephen O ^a   Ojewole, John A O ^b  

^a OBAFEMI AWOLOWO UNIVERSITY   (Nigeria)

^b UNIVERSITY OF KWAZULU NATAL   (South Africa)

Author keywords

Artocarpus communis; Hepatic tissues; Hyperglycaemic effects; Streptozotocin; Ultrastructural and metabolic changes

Indexed keywords

3 HYDROXYBUTYRATE DEHYDROGENASE; ARTOCARPUS COMMUNIS EXTRACT; FAT DROPLET; GLUCOKINASE; GLUCOSE; GLUTAMATE DEHYDROGENASE; HEXOKINASE; INSULIN; PLANT EXTRACT; STREPTOZOCIN; SUCCINATE DEHYDROGENASE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTOCARPUS COMMUNIS; BARK; CELL ULTRASTRUCTURE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; INSULIN BLOOD LEVEL; LIVER CELL; LIVER HISTOLOGY; LIVER MITOCHONDRION; MORACEAE; NIGERIA; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PLANT ROOT; RAT; ROUGH ENDOPLASMIC RETICULUM; STREPTOZOCIN DIABETES; TOXICITY TESTING; WISTAR RAT;

EID: 34748867153     PISSN: 01896016     EISSN: 01896016     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Afanas'ev, I. B., Dorozhko, I., Brodskii, A. V., Korstyuk, V. A. and Potapovitch, A. (1989). Chelating and free radical scavenging mechanisms of inhibitory action of rutin and quercetin in lipid peroxidation. Biochem Pharmacol., 38: 1763-1769.
2. Bailey, C. J. and Day, C. (1989). Traditional plant medicines as treatment for diabetes. Diabetes Care, 12: 553-564.
3. Bastar, I., Seckin, S., Uysal, M. and Aykac-Toker, G. (1998). Effects of streptozotocin on glutathione and lipid peroxide levels in various tissues of rats. Res Commun Mol Pathol Pharmacol., 102: 265-275.
4. Berdanier, C. D. (2001). Diabetes and nutrition. The mitochondrial part. J. Nutr., 131: 344S-353S.
5. Bessman, S. P. and Mohan, C. (1997). Insulin as a probe of mitochondrial metabolism in situ. Mol Cell Biochem., 174: 91-96.
6. Brady, L. J., Brady, P. S., Romsos, D. R. and Hoppel, C. L. (1985). Elevated hepatic mitochondrial and peroxisomal oxidative capacities in fed and starved adult obese(ob/ob) mice. Biochem J., 231: 439-444.
7. Chan, S. C., Ko, H. H. and Lin, C. N. (2003). New Prenylflavonoids from Artocarpus communis. J Nat Prod., 66: 427-430.
8. Chen, Y. T., Zheng, R. L, Jia, Z. J. and Ju, Y. (1990). Flavonoids as superoxide scavengers and antioxidants. Free Radic Biol Med., 9: 19-20.
9. Davidson, A. and Arion, W. J. (1987). Factors underlying significant underestimations of glucokinase activity in crude liver extracts: physiological implications of higher cellular activity. Arch Biochem Biophys., 253: 156-167.
10. Hall, J. C., Sordhal, L. A. and Stefko, P. L. (1960). Effect of insulin on oxidative phosphorylation in normal and diabetic mitochondria. J Biol Chem., 235: 1536-1539.
11. Henry, J. D. (1984). Clinical diagnosis and management by laboratory methods. 17th Edn. p. 1433.
12. Inal, M. E., Akgun, A. and Kahraman, A. (2002). Radio-protective effects of exogenous glutathione against whole-body gamma-ray irradiation: age- and gender-related changes in malondialdehyde levels, superoxide dismutase and catalase activities in rat liver. Methods Find Exp Clin Pharmacol., 24: 209-212.
13. Kamata, K., Mitsuya, M., Nishimura, T., Eiki, J. and Nagata, Y. (2004). Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase. Structure (Camb)., 12: 429-438.
14. Karnovsky, M. J. (1965). A formaldehyde-glutaraldehyde fixative of high osmolarity for use in electron microscopy. J Cell Biol., 27: 137A-138A.
15. Kasahara, S. and Hemmi, S. (1986). Medicinal herb index in Indonesia. Bogor: P.T. Eisai Indonesia p.184.
16. Katyare, S. S. and Satav, J. G. (1986). Impaired mitochondria oxidative energy metabolism following paracetamol-induced hepatotoxicity in the rat. Br J. Pharmacol., 96: 51-58.
17. Kavanagh, N. I., Ainscow, E. K. and Brand, M. D. (2000). Calcium regulation of oxidative phosphorylation in rat skeletal muscle mitochondria. Biochem Biophys Acta, 1457: 57-70.
18. Keen, R. W., Deacon, A. C., Delves, H. T., Moreton, J. A. and Frost, P. G. (1994). Indian herbal remedies for diabetes as a cause of lead poisoning. Postgrad Med., J. 70: 113-114.
19. Krital, B. S., Jackson, C. T., Chung, H. Y., Marsuda, M., Nguyen, H. D. and Yu, B. P. (1997). Defects at center p underlies diabetes-associated mitochondrial dysfunction. Free Radic Biol Med., 22: 823-833.
20. Kröncke, K. D., Fehsel, K., Sommer, A., Rodriguez, M. L. Kolb-Bachofen, V. (1995). Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-nitroso-urea: Streptozotocin contributes to islet cell DNA damage. Biol Chem Hoppe-Seyler, 376:179-185.
21. Leninger, D. and Cox, M. (2001). Principles of Biochemistry. 3rd Ed., Worth Publications, New York.
22. Levinie RL, Garland D, Oliver CN, Amici A, Ciment I, Lenz AG, Ahn BW., Shattie S, Stadtman ER (1990). Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol., 186: 464-478.
23. Lin, C. N. and Shieh, W. L. (1991). Prenylflavoniods and pyranodihydrobenzoxanthone from Artocarpus communis. Phytochemistry, 30: 1669-1671.
24. Lin, C. N., Shieh, B. J., Ko, F. N. and Teng, C. M. (1993). Antiplatelet activity of some prenylflavonoids. Biochem Pharmacol., 45: 509-512.
25. Lorke, D. A. (1983). A new approach to practical acute toxicity testing. Arch Toxich., 54, 275-287.
26. Lowry, O. H., Rosebrough, N. J., Farr, A. L. and Randall, R. J. (1951). Protein measurement with Folin phenol reagent. J. Biol.-Chem., 193: 265-275.
27. Matkovics, B., Kotorman, M., Varga, I. S., Hai, D. Q. and Varga, C. (1998). Oxidative stress in experimental diabetes induced by streptozotocin. Acta Physiol Hung., 85: 29-38.
28. Matschinsky FM, Magnuson MA (2004). Glucokinase and Glycemic Disease: From Basic to Novel Therapeutics. Basel: Karger (eds.).
29. Middleton, Jr. E. (1998). Effects of plant flavonoids on immune and inflammatory cell function. Adv Exp Med Biol., 439: 175-182.
30. Nishihara, Y., Robertson, L. W., Oesch, F. and Utsumi, K. (1986). The effects of tetrachlorobiphenyls on the electron transfer reaction of isolated rat liver mitochondria. Life Sci., 38: 627-635.
31. Park, C. and Drake, R. L. (1982). Insulin mediates the stimulation of pyruvate kinase by a dual mechanism. Biochem J., 208: 333-337.
32. Postic, C., Shiota, M. and Magnuson, M. A. (2001). Cell-specific roles of glucokinase in glucose homeostasis. Recent Progress in Hormone Research, 56: 195-218.
33. Rogers, K.S., Friend, W. H. and Higgins, E. S. (1986). Metabolic and mitochondrial disturbances in streptozotocin-treated Sprague-Dawley and Sherman rats. Proc Soc Explt I Biol Med., 182: 167-175.
34. Rossini, A. A., Williams, R. M., Appel, M. C. and Like, A. A. (1979). Complete protection from low-dose streptozotocin-induced diabetes in mice. Nature, 276: 182-184.
35. Singer, T. P. (1974). Determination of the activity of succinate, NADH, choline, and α-glycerophosphate dehydrogenases. In: Methods of Biochemical Analysis, D. Glick, ed., Wiley, New York, pp. 123-175.
36. Striker, G. E., Peten, E. P., Carome, M. A., Pesce, C. M., Schmidt, K., Yang, C. W., Elliot, S. J. and Striker, L. J. (1993). Kidney disease of diabetes mellitus (KDDM). A cell and molecular biology approach. Diabetes/Metabolism Rev., 9: 37-56.
37. Tiedge, M., Lortz, S., Drinkgern, J. and Lenzen, S. (1997). Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes, 46: 1733-1742.
38. Tindal, H. D. (1965). Fruits and vegetables of West Africa. Food and Agriculture Organization of the United Nations, Rome, p. 259.
39. Venable, J. H. and Coggeshall, R. A. (1966). Simplified lead citrate stain for use in electron microscopy. J Cell Biol., 25: 407-408.
40. Wang, Y. H., Hou, A. J., Chen, L., Chen, D. F., Sun, H. D., Zhao, Q. S., Bastow, K. F., Nakanish, Y., Wang, X. H., and Lee, K. H. (2004). New isoprenylated flavonoes, artchamins A-E, and cytotoxic principles from Artocarpus chana. J Nat Prod., 67: 757-761.
41. Wei, B. L, Weng, J. R., Chiu, P. H., Hung, C. F., Wang, J. P. and Lin, C. N. (2005). Antiinflammatory flavonoids from Artocarpus communis. J Agr Food Chem., 53: 3867-3871.