Effects of bioactive peptides isoleucine-proline-proline (IPP), valine-proline-proline (VPP) and leucine-lysine-proline (LKP) on gene expression of osteoblasts differentiated from human mesenchymal stem cells

British Journal of Nutrition

Volumn 98, Issue 4, 2007, Pages 780-788

  Huttunen, Minna M ^a   Pekkinen, Minna ^a   Ahlström, Mikael E B ^a   Lamberg Allardt, Christel J E ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Bioactive peptide; Dietary protein; IPP; Osteoblast proliferation

Indexed keywords

BONE MORPHOGENETIC PROTEIN 5; CASPASE 8; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ISOLEUCYPROLYLPROLINE; LEUCYLLYSYLPROLINE; PARATHYROID HORMONE RELATED PROTEIN; TRIPEPTIDE DERIVATIVE; UNCLASSIFIED DRUG; VALYLPROLYLPROLINE; VITAMIN D RECEPTOR;

ANIMAL CELL; ARTICLE; BONE MASS; BONE STRUCTURE; CELL DIFFERENTIATION; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; DRUG EFFECT; FRACTURE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MESENCHYMAL STEM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; OSTEOSARCOMA CELL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

AMINO ACIDS, BRANCHED-CHAIN; BONE MARROW CELLS; CELL DIFFERENTIATION; FEMALE; GENE EXPRESSION; HUMANS; ISOLEUCINE; LYSINE; MALE; MESENCHYMAL STEM CELLS; OSTEOBLASTS; OSTEOGENESIS; PROLINE; VALINE;

EID: 34748856815     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114507744434     Document Type: Article

References (47)

1. Hannan MT, Tucker KL, Dawson-Huges B, Cupples LA, Felson DT & Kiel DP (2000) Effect of dietary protein on bone loss in elderly men and women: The Framingham Osteoporosis Study. J Bone Miner Res 15, 2504-2512.
2. Dawson-Huges B & Harris SS (2002) Calcium intake influences the association of protein intake with rates of bone loss in elderly men and women. Am J Clin Nutr 75, 773-779.
3. Kerstetter JE, O'Brien KO & Insogna KL (2003) Low protein intake: The impact on calcium and bone homeostasis irr humans. J Nutr 133 855S-861S.
4. Wengreen HJ, Munger RG, West NA, Cutler DR, Corcoran CD, Zhang J & Sassano NE (2004) Dietary protein intake and risk of osteoporotic hip fracture in elderly residents of Utah. J Bone Miner Res 19, 537-545.
5. Bastow MD, Rawlings J & Allison SP (1983) Benefits of supplementary tube feeding after fracture neck of femur. Br Med J 287, 1589-1592.
6. Delmi M, Rapin C-H, Bengoa JM, Delmas PD, Vasey H & Bonjour J-P (1990) Dietary supplementation in elderly patients with fractured neck of the femur. Lancet 335, 1013-1016.
7. Rizzoli R & Bonjour J-P (2004) Dietary protein and bone health. J Bone Miner Res 19, 527-531.
8. Oxlund H, Barckman M, Ørtoft G & Andreassen TT (1995) Reduced concentrations of collagen cross-links are associated with reduced strength of bone. Bone 17, 365S-371S.
9. Heaney RP (2002) Protein and calcium: Antagonists or synergists? Am J Clin Nutr 75, 609-610.
10. Kerstetter JE, O'Brien KO, Caseria DM, Wall DE & Insogna KL (2005) The impact of dietary protein on calcium absorption and kinetic measures of bone turnover in women. J Clin Endocrinol Metab 90, 26-31.
11. Thissen JP, Ketelslegers JM & Underwood LE (1994) Nutritional regulation of the insulin-like growth factors. Endocr Rev 15, 80-101.
12. Rutherfurd-Markwick KJ & Moughan PJ (2005) Bioactive peptides derived from food. J AOAC Int 88, 955-966.
13. Hartmann R & Meisel H (2007) Food-derived peptides with biological activity: From research to food applications. Curr Opin Biotechnol 18, 1-7.
14. Fujita H & Yoshikawa M (1999) LKPNM: A prodrug-type ACE-inhibitory peptide derived from fish protein. Immunopharmacology 44, 123-127.
15. Shimizu M (2004) Food-derived peptides and intestinal functions. Biofactors 21, 43-47.
16. Satake M, Enjoh M, Nakamura Y, Takano T, Kawamura Y, Arai S & Shimizu M (2002) Transepithelial transport of the bioactive tripeptide, Val-Pro-Pro, in human intestinal Caco-2 cell monolayers. Biosci Biotechnol Biochem 66, 378-384.
17. Froetschel MA, Azain MJ, Edwards GL, Barb CR & Amos HE (2001) Opioid and cholecystokinin antagonists alleviate gastric inhibition of food intake by premeal loads of casein in meal-fed rats. J Nutr 131, 3270-3276.
18. Aimutis WR (2004) Bioactive properties of milk proteins with particular focus on anticariogenesis. J Nutr 134, 989S-995S.
19. FizGerald RJ, Murray BA & Walsh DJ (2004) Hypotensive peptides from milk proteins. J Nutr 134, 980S-988S.
20. Curtis JM, Dennis D, Waddell DS, MacGillivray T & Ewart HS (2002) Determination of angiotensin-converting enzyme inhibitory peptide Leu-Lys-Pro-Asn-Met (LKPNM) in bonito muscle hydrolysates by LC-MS/MS. J Agric Food Chem 50, 3919-3925.
21. Narva M, Collin M, Lamberg-Allardt C, Kärkkäinen M, Poussa T, Vapaatalo H & Korpela R (2004) Effects of long-term intervention with Lactobacillus helveticus-fermented milk on bone mineral density and bone mineral content in growing rats. Ann Nutr Metab 8, 228-234.
22. Narva M, Nevala R, Poussa T & Korpela R (2004) The effect of Lactobacillus helveticus fermented milk on acute changes in calcium metabolism in postmenopausal women. Eur J Nutr 43, 61-68.
23. Stanford CM, Jacobson PA, Eanes EA, Lembke LA & Midura RJ (1995) Rapidly forming apatic mineral in an osteoblastic cell line (UMR 106-01). J Biol Chem 270, 9420-9428.
24. Bodine PV, Trailsmith M & Komm BS (1996) Development and characterization of a conditionally transformed adult human osteoblastic cell line. J Bone Miner Res 11, 806-819.
25. Kerr MK & Churchill GA (2001) Experimental design for gene expression microarrays. Biostatistics 2, 183-201.
26. Ahlström M, Pekkinen M, Huttimen M & Lamberg-Allardt C (2004) Dexamethasone down-regulates cAMP-phosphodiesterase in human osteosarcoma cells. Biochem Pharmacol 69, 267-275.
27. Amedee J, Bareille R, Rouais F, Cunningham N, Reddi H & Harmand M (1994) Osteogenin (bone morphogenetic protein 3) inhibits proliferation and stimulates differentiation of osteoprogenitors in human bone marrow. Differentiation 58, 157-164.
28. Huag H, Zhao Y, Liu Z, Zhang Y, Zhang H, Fu T & Ma X (2003) Enhanced osteoblast functions on RGD immobilized surface. J Oral Implantol 29, 73-79.
29. Benoit DSW & Anseth KS (2005) The effect on osteoblast function of colocalized RGD and PHSRN epitopes on PEG surfaces. Biomaterials 26, 5209-5220.
30. Dempster DW, Cosman F, Parisien M, Shen V & Lindsay R (1993) Anabolic actions of parathyroid hormone on bone. Endocr Rev 14, 690-709.
31. Swarthout JT, Dogget TA, Lemker JL & Partridge NC (2001) Stimulation of extracellular signal-regulated kinases and proliferation in rat osteoblastic cells by parathyroid hormone in protein kinase C-dependent. J Biol Chem 276, 7586-7592.
32. Walsh CA, Bowler WB, Bilbe G, Fraser WD & Gallagher JA (1997) Effects of PTHrP gene expression in human osteoblasts: Up-regulation with the kinetics of an immediate early gene. Biochem Biophys Res Commun 239, 155-159.
33. Karaplis AC & Goltzman D (2000) PTH and THrP effects on the skeleton. Rev Endocr Metab Disord 1, 331-341.
34. Swarthout JT, D'Alonzo RC, Selvamurugan N & Partridge N (2002) Parathyroid hormone-dependent signalling pathways regulating genes in bone cells. Gene 282, 1-17.
35. Ebisawa T, Tada K, Kitajima I, Tojo K, Sampath TK, Kawabata M, Miyazono K & Imamura T (1999) Characterization of bone morphogenetic protein-6 signalling pathways in osteoblast differentiation. J Cell Sci 112, 3519-3527.
36. Canalis E, Economides AN & Gazzerro E (2003) Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev 24 218-235.
37. Wozney JM (2002) Overview of bone morphogenetic proteins. Spine 27, S2-S8.
38. Sooy K, Sabbagh Y & Demay MB (2005) Osteoblasts lacking the vitamin D receptor display enhanced osteogenic potential in vitro. J Cell Biochem 94, 81-87.
39. Tanaka H & Seino Y (2004) Direct action of 1,25-dihydroxy-vitamin D on bone: VDRKO bone shows excessive bone formation in normal mineral condition. J Steroid Biochem Mol Biol 89/90, 343-345.
40. Narva M, Halleen J, Väänänen K & Korpela R (2004) Effects of Lactobacillus helveticus fermented milk on bone cells in vitro. Life Sci 75, 1727-1734.
41. Jilka RL, Weinstein RS, Bellido T, Parfitt AM & Manolagas SC (1998) Osteoblast programmed cell death (apoptosis): Modulation by growth factors and cytokines. J Bone Miner Res 13, 793-802.
42. Morales O, Samuelsson MKR, Lindgren U & Haldosén L (2004) Effects of 1α,25-dihydroxyvitamin D3 and growth hormone on apoptosis and proliferation in UMR 106 osteoblast-like cells. Endocrinology 145, 97-94.
43. Wordinger RJ, Agarwal R, Talati M, Fuller J, Lambert W & Clark AF (2002) Expression of bone morphogenetic proteins (BMP), BMP receptors, and BMP associated proteins in human trabecular meshwork and optic nerve head cells and tissues. Mol Vis 8, 241-250.
44. Emmanuele L, Ortmann J, Doerflinger T, Traupe T & Barton M (2003) Lovastin stimulates human vascular smooth muscle cell expression of bone morphogenetic protein-2, a potent inhibitor of low-density lipoprotein-stimulated cell growth. Biochem Biophys Res Commun 320, 67-72.
45. Gomes AC, Jönsson G, Mjörnheim S, Olsson T, Hillert J & Grandien A (2003) Upregulation of the apoptosis regulators cFLIP, CD95, and CD95 ligand in peripheral blood mononuclear cells in relapsing-remitting multiple sclerosis. J Neuroimmunol 135, 126-134.
46. Kuliwaba JS, Findlay DM, Atkins GJ, Forwood MR & Fazzalari NL (2000) Enhanced expression of osteocalcin mRNA in human osteoarthritic trabecular bone of the proximal femur is associated with decreased expression of interleukin-6 and interleukin-11 mRNA. J Bone Miner Res 15, 332-341.
47. Richard V, Luchin A, Brena RM, Plass C & Rosol TJ (2003) Quantitative evaluation of alternative promoter usage and 3′ splice variants for parathyroid hormone-related protein by real-time reverse transcription-PCR. Clin Chem 49, 1398-1402.