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For examples of metal-mediated diaminations, see: Co: (a) Becker, P. N, White, M. A, Bergman, R. G. J. Am. Chem. Soc. 1980, 102, 5676
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For examples of metal-mediated diaminations, see: Co: (a) Becker, P. N.; White, M. A.; Bergman, R. G. J. Am. Chem. Soc. 1980, 102, 5676.
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6
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Mn: c
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Mn: (c) Fristad, W. E.; Brandvold, T. A.; Peterson, J. R.; Thompson, S. R. J. Org. Chem. 1985, 50, 3647.
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Os: (d) Chong, A. O.; Oshima, K.; Sharpless, K. B. J. Am. Chem. Soc. 1977, 99, 3420.
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For a recent Cu(II)-mediated intramolecular diamination, see: (a) Zabawa, T. P.; Kasi, D.; Chemler, S. R. J. Am. Chem. Soc. 2005, 127, 11250.
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For a recent Cu(II)-mediated intramolecular diamination, see: (a) Zabawa, T. P.; Kasi, D.; Chemler, S. R. J. Am. Chem. Soc. 2005, 127, 11250.
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2, see: (a) Li, G.; Wei, H.-X.; Kim, S. H.; Carducci, M. D. Angew. Chem., Int. Ed. 2001, 40, 4277.
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2, see: (a) Li, G.; Wei, H.-X.; Kim, S. H.; Carducci, M. D. Angew. Chem., Int. Ed. 2001, 40, 4277.
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For a recent Pd(II)-catalyzed intermolecular diamination of conjugated dienes, see: Bar, G. L. J.; Lloyd-Jones, G. C.; Booker-Milburn, K. I. J. Am. Chem. Soc. 2005, 127, 7308.
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For a recent Pd(II)-catalyzed intermolecular diamination of conjugated dienes, see: Bar, G. L. J.; Lloyd-Jones, G. C.; Booker-Milburn, K. I. J. Am. Chem. Soc. 2005, 127, 7308.
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16
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27144440348
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For a recent Pd(II)-catalyzed intramolecular diamination of terminal olefins, see: Streuff, J.; Hövelmann, C. H.; Nieger, M.; Muñiz, K. J. Am, Chem. Soc. 2005, 127, 14586.
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For a recent Pd(II)-catalyzed intramolecular diamination of terminal olefins, see: Streuff, J.; Hövelmann, C. H.; Nieger, M.; Muñiz, K. J. Am, Chem. Soc. 2005, 127, 14586.
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For leading references on L4-L6, see: (a) de Vries, A. H. M.; Meetsma, A.; Feringa, B. L. Angew. Chem., Int. Ed. Engl. 1996, 35, 2374.
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34748906059
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A ratio of 1:2.2 for Pd/L7 was found to be optimal for the conversion. Similar ee's with somewhat lower conversion were obtained in toluene.
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A ratio of 1:2.2 for Pd/L7 was found to be optimal for the conversion. Similar ee's with somewhat lower conversion were obtained in toluene.
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32
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0032540965
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For leading references on L8 and L9, see: (a) Keller, E.; Maurer, J.; Naasz, R.; Schader, T.: Meetsma, A.; Feringa, B. L. Tetrahedron: Asymmetry 1998, 9, 2409.
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For leading references on L8 and L9, see: (a) Keller, E.; Maurer, J.; Naasz, R.; Schader, T.: Meetsma, A.; Feringa, B. L. Tetrahedron: Asymmetry 1998, 9, 2409.
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34
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No diamination at allylic and homoallylic carbons was observed with alkyl-substituted dienes under the current reaction conditions
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No diamination at allylic and homoallylic carbons was observed with alkyl-substituted dienes under the current reaction conditions.
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35
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34748831156
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Styrene was not an effective substrate, and a small amount of diamination product at allylic and homoallylic carbons was formed with 1-hexene under the current reaction conditions
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Styrene was not an effective substrate, and a small amount of diamination product at allylic and homoallylic carbons was formed with 1-hexene under the current reaction conditions.
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36
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33646438818
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For a leading reference on biologically active cyclic ureas, see
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Diamino acids are present in many biologically active molecules; for examples, see: a
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Diamino acids are present in many biologically active molecules; for examples, see: (a) Shigematsu, N.; Setoi, H.; Uchida, I.; Shibata, T.; Terano, H.; Hashimoto, M. Tetrahedron Lett. 1988, 29, 5147.
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43
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34748919579
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The ee of 8 was determined after being converted into diamide; the ee's of 10 and 12 were determined after being converted into methyl esters.
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The ee of 8 was determined after being converted into diamide; the ee's of 10 and 12 were determined after being converted into methyl esters.
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