Adult sexual abuse is associated with elevated neurohormone levels among women with PTSD due to childhood sexual abuse

Journal of Traumatic Stress

Volumn 20, Issue 4, 2007, Pages 611-617

  Friedman, Matthew J ^a,b   Jalowiec, John ^a,b   McHugo, Gregory ^a,b,c   Wang, Sheila ^d   McDonagh, Annmarie ^a,b  

^a NATIONAL CENTER FOR PTSD   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c DARTMOUTH PSYCHIATRIC RESEARCH CENTER   (United States)

^d CHILDREN'S MEMORIAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; HYDROCORTISONE; NEUROHORMONE; NORADRENALIN;

ADULT; AGED; COGNITIVE THERAPY; CONFERENCE PAPER; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; HUMAN; HYDROCORTISONE URINE LEVEL; MAJOR CLINICAL STUDY; POSTTRAUMATIC STRESS DISORDER; SEXUAL ABUSE; URINALYSIS;

ADULT; AGE FACTORS; AROUSAL; CHILD; CHILD ABUSE, SEXUAL; COGNITIVE THERAPY; DOPAMINE; FEMALE; HUMANS; HYDROCORTISONE; MIDDLE AGED; NOREPINEPHRINE; PSYCHOTHERAPY; SEX OFFENSES; STRESS DISORDERS, POST-TRAUMATIC; TREATMENT OUTCOME;

EID: 34748825511     PISSN: 08949867     EISSN: 15736598     Source Type: Journal    
DOI: 10.1002/jts.20221     Document Type: Conference Paper

References (25)

1. Baker, D. G., West, S. A., Nicholson, W. E., Ekhator, N. N., Kasckow, J. W., Hill, K. K., et al. (1999). Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder. American Journal of Psychiatry, 156, 585-588.
2. Beck, A. T., Steer, R., & Garbing, M. G. (1988). Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation. Clinical Psychology Review, 8, 77-100.
3. Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Gusman, F. D., Charney, D. S. et al. (1995). The development of a Clinician-Administered PTSD Scale. Journal of Traumatic Stress, 8, 75-90.
4. Briere, J. N., & Runtz, M. G. (1993). Childhood sexual abuse: long-term sequelae and implications for psychological assessment. Journal of Interpersonal Violence, 8, 312-330.
5. Carroll, B. J., Curtis, G. C., Davies, M. B., Mendels, J., & Sugarman, A. A. (1976). Urinary free cortisol excretion in depression. Psychological Medicine, 6, 43-50.
6. First, M. G., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (1996). Structured Clinical Interview for DSM-IV Disorders-Patient Version (SCID-I/P, Version 2.0). New York: Biometric Department, New York Psychiatric Institute.
7. Kosten, T. R., Mason, J. W., Giller, E. L., Ostroff, R. B., & Harkness, L. L. (1987). Sustained urinary norepinephrine and epinephrine elevation in post-traumatic stress disorder. Psychoneuroendocrinology, 12, 13-20.
8. Kosten, T. R., Wahby, V., Giller, E., & Mason, J. (1990). The dexamethasone suppression test in posttraumatic stress disorder. Biological Psychiatry, 28, 657-664.
9. Krinsley, K. E., Weathers, F. W., Vielhauer, M. J., Newman, E., Walker, E. A., Young, L. S., et al. (1994). The evaluation of lifetime stressors. Boston: National Center for PTSD, Behavioral Science Division.
10. Lemieux, A., & Coe, C. (1995). Abuse-related posttraumatic stress disorder: Evidence for chronic neuroendocrine activation in women. Psychosomatic Medicine, 57, 105-115.
11. Maes, M., Lin, A., Bonaccorso, S., Van Hunsel, F., Van Gastel, A., Delmeire, L., et al. (1998). Increased 24-hour urinary cortisol excretion in patients with post-traumatic stress disorder and patients with major depression, but not in patients with fibromyalgia. Acta Psychiatrica Scandinavica, 98, 328-335.
12. Mason, J. W., Giller, E. L., Kosten, T. R., Ostroff, R. B., & Podd, L. (1986). Urinary-free cortisol levels in posttraumatic stress disorder patients. Journal of Nervous and Mental Disease, 174, 145-159.
13. Mason, J. W., Wang, S., Riney, S., Charney, D. S., & Southwick, S. M. (2001). Psychogenic lowering of urinary cortisol levels linked to increased emotional numbing and a shame-depressive syndrome in combat-related posttraumatic stress disorder. Psychosomatic Medicine, 63, 387-401.
14. Mason, J., Wang, S., Yehuda, R., Lubin, H., Johnson, D., Bremner, J.D., et al. (2002). Marked lability in urinary-free cortisol levels in sub-groups of combat veterans with posttraumatic stress disorder during an intensive exposure treatment program. Psychosomatic Medicine, 64, 238-246.
15. McDonagh, A., Friedman, M. J., McHugo, G., Ford, J., Sengupta, A., Mueser, K., et al. (2005). Randomized trial of cognitive behavioral therapy for chronic PTSD in adult female childhood sexual abuse survivors. Journal of Consulting and Clinical Psychology, 73, 515-524.
16. Pitman, R., & Orr, S. (1990). Twenty-four hour urinary cortisol and catecholamine excretion in combat-related posttraumatic stress disorder. Biological Psychiatry, 27, 245-247.
17. Rasmusson, A. M., & Friedman, M. J. (2002). Gender issues in the neurobiology of PTSD. In R. Kimerling, P. C. Ouimette, & J. Wolfe (Eds.), Gender and PTSD (pp. 43-75). New York: Guilford Press.
18. Rasmusson, A. M., Lipschitz, D. S., Wang, S., Hu, S., Vojvoda, D., Bremner, J. D., et al. (2001). Increased pituitary and adrenal reactivity in premenopausal women with posttraumatic stress disorder. Biological Psychiatry, 50, 965-977.
19. Southwick, S. M., Davis, L., Aikens, D. E., Rasmusson, A. M., Barron, J., & Morgan, C. A. (2007). Neurobiological alterations associated with PTSD. In M. J. Friedman, T. M. Keane, & P. A. Resick (Eds.), Handbook of PTSD: Science and practice (pp. 166-189). New York: Guilford Press.
20. Southwick, S. M., Paige, S. R., Morgan, C. A., Bremner, D. B., Krystal, J. H., & Charney, D. S. (1999). Adrenergic and serotonergic abnormalities in PTSD: Catecholamines and serotonin. Seminars in Clinical Neuropsychiatry, 4, 242-248.
21. Spielberger, C. D., Gorusch, R., Luschene, R., Vagg, P. R., & Jacobs, G. A. (1970). Manual for the State-Trait Anxiety Inventory (self-evaluation questionnaire). Palo Alto, CA: Consulting Psychologists Press.
22. Weathers, F., Keane, T. M., & Davidson, J. R. T. (2001). Clinician-Administered PTSD Scale: A review of the first ten years of research. Depression and Anxiety, 13, 132-156.
23. Yehuda, R., Teicher, M., Trestman, R., Levengood, R., & Siever, L. (1996). Cortisol regulation in posttraumatic stress disorder and major depression: A chronobiological analysis. Biological Psychiatry, 40, 79-88.
24. Young, E. A., & Breslau, N. (2004) Cortisol and catecholamines in posttraumatic stress disorder: An epidemiologic community study. Archives of General Psychiatry, 61, 394-401.
25. Young, E. A., Tolman, R., Witkowski, K., & Kaplan, G. (2004) Salivary cortisol and posttraumatic stress disorder in a low-income community sample of women. Biological Psychiatry, 55, 621-626.