Hypercoagulability and platelet inhibition after OPCAB. Randomized intervention with clopidogrel

Scandinavian Cardiovascular Journal

Volumn 41, Issue 5, 2007, Pages 325-330

  Nielsen, Allan Bybeck ^a   Bochsen, Louise ^a   Steinbrüchel, Daniel A ^a  

^a Rigshospitalet   (Denmark)

Author keywords

Clopidogrel; Hypercoagulability; Off Pump Coronary Artery Bypass; Platelet inhibition; Thrombelastography

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; ENOXAPARIN; HEPARIN; PROTAMINE; WARFARIN;

ADD ON THERAPY; ADULT; AGED; ANTICOAGULANT THERAPY; ARTICLE; BLOOD SAMPLING; CHEMOPROPHYLAXIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS SURGERY; FEMALE; FOLLOW UP; GRAFT PATENCY; HUMAN; HYPERCOAGULABILITY; MALE; OFF PUMP CORONARY SURGERY; POSTOPERATIVE CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE AGGREGATION INHIBITION; THROMBOELASTOGRAPHY; THROMBOEMBOLISM; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT;

ADULT; AGED; AGED, 80 AND OVER; ANTICOAGULANTS; CORONARY ARTERY BYPASS, OFF-PUMP; FEMALE; HUMANS; MALE; MIDDLE AGED; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PROSPECTIVE STUDIES; THROMBELASTOGRAPHY; THROMBOEMBOLISM; THROMBOPHILIA; TICLOPIDINE;

EID: 34748825023     PISSN: 14017431     EISSN: 16512006     Source Type: Journal    
DOI: 10.1080/14017430701383763     Document Type: Article

References (21)

1. D'Ancona, G., Donias, HW and Karamanoukian, RL (2001) OPCAB therapy survey: Off-pump clopidogrel, aspirin or both therapy survey. The Heart Surgery Forum., 4, pp. 354-358.
2. Hansen, KH, Hughes, P. and Steinbrüchel, DA. (2005) Antithrombotic- and anticoagulation regimens in OPCAB surgery. A Nordic Survey. Scand Cardiovasc J., 39, pp. 369-374.
3. Kurlansky, PA. (2003) Is there a hypercoagulable state after off-pump coronary artery bypass surgery? What do we know and what can we do?. J Thorac Cardiovasc Surg., 126, pp. 7-10.
4. Mack, MJ, Osborne, JA and Shennib, H. (1998) Arterial graft patency in coronary artery bypass grafting: What do we really know?. Ann Thorac Surg., 66, pp. 1055-1059.
5. Moor, E., Blombac, M. and Silveira, A. (2000) Haemostatic function in patients under-going coronary artery bypass grafting: Perioperative perturbations and relations to saphenous vein graft closure. Throm Res., 98, pp. 39-49.
6. Bick, RL. (2000) Thrombotic and hemorrhagic problems during cardiopulmonary bypass surgery and cardiovascular procedures. Management of bleeding in cardiovascular surgery, pp. 9-62. Hanley & Belfus Inc, Philadelpia
7. Puskas, JD, Williams, WH and Duke, PG (2003) Off-pump coronary artery bypass grafting provides complete revascularization with reduced myocardial injury, transfusion requirements, and length of stay. J Thorac Cardiovasc Surg., 125, pp. 797-806.
8. Mariani, MA, Gu, YJ, Boonstra, PW, Grandjean, JG, Oeveren, WV and Ebels, T. (1999) Procoagulant activity after off-pump coronary operation: Is the current anticoagulation adequate?. Ann Thorac Surg., 67, pp. 1370-1375.
9. Kim, K-B, Lim, C., Lee, C., Chae, I-O, Oh, B-H and Lee, M-M (2001) Off-pump coronary artery bypass may decrease the patency of saphenous vein grafts. Ann Thoras Surg., 72, pp. S1033-S1037.
10. Quigley, RL, Fried, DW, Pym, J. and Highbloom, RY. (2002) Off-pump coronary artery bypass surgery may produce a hypercoagulable patient. Heart Surg For., 6, pp. 94-98.
11. Møller, CH and Steinbrüchel, DA. (2003) Platelet function after coronary artery bypass grafting: Is there a procoagulant activity after off-pump compared with on-pump surgery. Scand Cardiovasc J., 37, pp. 149-153.
12. The CAPRIE steering committee (1996) A randomised, blinded trial of clopidogrel versus aspirin in patients at risk of ischaemic events. Lancet., 348, pp. 1329-1339.
13. Yusuf, F., Zhao, F. and Metha, SR (2001) Effects of clopidogrel in addition to aspirin in patients with acute coronary syndrome without ST-segment elevation. N Engl J Med., 345, pp. 494-502.
14. Braunwald, E., Antman, Em and Beasley, JW (2002) ACC/AHA guideline update for the management of patients with unstable angina and Non-ST-segment elevation myocardial infarction. Circulation., 106, pp. 1893-1900.
15. Craft, RM, Chavez, JJ and Bresee, SJ (2004) A novel modification of the Thrombelastograph assay, isolating platelet function, correlates with optical platelet aggregation. J Lab Clin Med., 143, pp. 301-309.
16. Gerrah, R., Snir, E. and Brill, A. (2004) Platelet function changes as monitored by cone and plate(let) analyzer during beating heart surgery. Heart Surg Forum., 7, pp. E191-E195.
17. Vig, S., Chitolie, A. and Bevan, DH (2001) Thrombelastography: A reliable test?. Blood Coagul Fibrinolysis., 12, pp. 555-561.
18. Jaremo, P., Lindahl, TL and Fransson, SG (2002) Individual variations of platelet inhibition after loading doses of clopidogrel. J Intern Med., 252, pp. 233-238.
19. Mobley, JE, Bresee, SJ and Wortham, DC (2004) Frequency of nonresponse antiplatelet activity of clopidogrel during pretreatment for cardiac catheterization. Am J Cardiol., 93, pp. 456-458.
20. Nguyen, TA, Diodati, JG and Pharand, C. (2005) Resistance to clopidogrel: A review of the evidence. J Am Coll Cardiol., 45, pp. 1157-1164.
21. Craft, RM, Chavez, JJ and Snider, CC (2005) Comparison of modified Thrombelastograph and Plateletworks whole blood assays to optical platelet aggregation for monitoring reversal of clopidogrel inhibition in elective surgery patients. J Lab Clin Med., 145, pp. 309-315.