Combined continuous ethinyl estradiol/norethindrone acetate does not improve forearm blood flow in postmenopausal women at risk for cardiovascular events: A pilot study

Journal of Women's Health

Volumn 16, Issue 7, 2007, Pages 963-970

  Duvernoy, Claire S ^a,b   Rose, Patricia A ^a   Kim, H Myra ^a   Kehrer, Christine ^a   Brook, Robert D ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTILIPEMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; C REACTIVE PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ETHINYLESTRADIOL PLUS NORETHISTERONE ACETATE; GLYCERYL TRINITRATE; HIGH DENSITY LIPOPROTEIN; PLACEBO; PLASMINOGEN ACTIVATOR INHIBITOR 1; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AGED; ARTICLE; BLOOD VESSEL REACTIVITY; BRACHIAL ARTERY; CARDIOVASCULAR EFFECT; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CLINICAL TRIAL; COLD PRESSOR TEST; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG EFFECT; ESTROGEN THERAPY; FEMALE; FIBRINOLYSIS; FOREARM BLOOD FLOW; HORMONE SUBSTITUTION; HUMAN; HYPERCHOLESTEROLEMIA; HYPEREMIA; HYPERTENSION; INFLAMMATION; MENOPAUSAL SYNDROME; PILOT STUDY; POSTMENOPAUSE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VASCULAR ENDOTHELIUM;

AGED; C-REACTIVE PROTEIN; CARDIOVASCULAR DISEASES; CHOLESTEROL, HDL; CHOLESTEROL, LDL; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; ENDOTHELIN-1; ESTROGEN REPLACEMENT THERAPY; ETHINYL ESTRADIOL; FEMALE; FOREARM; HUMANS; MIDDLE AGED; NORETHINDRONE; PILOT PROJECTS; PLASMINOGEN ACTIVATOR INHIBITOR 1; POSTMENOPAUSE; REGIONAL BLOOD FLOW; TREATMENT OUTCOME; VASCULAR CELL ADHESION MOLECULE-1; WOMEN'S HEALTH;

EID: 34748820778     PISSN: 15409996     EISSN: None     Source Type: Journal    
DOI: 10.1089/jwh.2006.0321     Document Type: Article

References (26)

1. Gerhard M, Walsh B, Tawakol A, et al. Estradiol therapy combined with progesterone and endothelium-dependent vasodilation in postmenopausal women. Circulation 1998;98:1158.
2. Gilligan DM, Quyyumi AA, Cannon R. Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women. Circulation 1994;89:2545.
3. Hulley S, Grady D, Bush T, et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA 1998;280:605.
4. Rossouw JE, Anderson GL, Prentice RL, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: Principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002;288:321.
5. Williams J, Honoré E, Washburn S, Clarkson T. Effects of hormone replacement therapy on reactivity of atherosclerotic coronary arteries in cynomolgus monkeys. J Am Coll Cardiol 1994;24:1757.
6. Anderson TJ, Uehata A, Gerhard MD, et al. Close relation of endothelial function in the human coronary and peripheral circulations. J Am Coll Cardiol 1995;26:1235.
7. Zeiher A, Drexler H, Wollschlaeger H, Saurbier B, Just J. Coronary vasomotion in response to sympathetic stimulation in humans: Importance of the functional integrity of the endothelium. J Am Coll Cardiol 1989;14:1181.
8. Antony I, Aptecar E, Lerebours G, Nitenberg A. Coronary artery constriction caused by the cold pressor test in human hypertension. Hypertension 1994;24:212.
9. Corretti MC, Plotnick GD, Vogel RA. Correlation of cold pressor and flow-mediated brachial artery diameter responses with the presence of coronary artery disease. Am J of Cardiol 1995;75:783.
10. Corretti MC, Plotnick GD, Vogel RA. The effects of age and gender on brachial artery endothelium-dependent vasoactivity are stimulus-dependent. Clin Cardiol 1995;18:471.
11. Liang K-Y, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika 1986;73:13.
12. Herrington DM, Espeland MA, Crouse JR 3rd, et al. Estrogen replacement and brachial artery flow-mediated vasodilation in older women. Arterioscl thromb Vascular Biol 2001;21:1955.
13. Kelemen M, Vaidya D, Waters DD, et al. Hormone therapy and antioxidant vitamins do not improve endothelial vasodilator function in postmenopausal women with established coronary artery disease: A sub-study of the Women's Angiographic Vitamin and Estrogen (WAVE) trial. Atherosclerosis 2005;179:193.
14. Lacut K, Oger E, Le Gal G, et al. Differential effects of oral and transdermal postmenopausal estrogen replacement therapies on C-reactive protein. Thromb Haemost 2003;90:124.
15. Duvernoy C. Estrogen and C-reactive protein: Does an alternate route lead to a more attractive destination? Thromb Haemost 2003;90:1.
16. Zegura B, Guzic-Salobir B, Ebestjen M, Keber I. The effect of various menopausal hormone therapies on markers of inflammation, coagulation, fibrinolysis, lipids, and lipoproteins in healthy postmenopausal women. Menopause 2006;13:643.
17. Colacurci N, Manzella D, Fornaro F, Carbonella M, Paolisso G. Endothelial function and menopause: Effects of raloxifene administration. J Clin Endocrinol Metab 2003;88:2135.
18. Vitale C, Cornoldi A, Gebara O, et al. Interleukin-6 and flow-mediated dilatation as markers of increased vascular inflammation in women receiving hormone therapy. Menopause 2005;12:552.
19. Bottcher M, Madsen MM, Refsgaard J, et al. Peripheral flow response to transient arterial forearm occlusion does not reflect myocardial perfusion reserve. Circulation 2001;103:1109.
20. Stolen KQ, Kemppainen J, Kalliokoski KK, et al. Myocardial perfusion reserve and peripheral endothelial function in patients with idiopathic dilated cardiomyopathy. Am J Cardiol 2004;93:64.
21. Victor RG, Leimbach WN Jr., Seals DR, Wallin BG, Mark AL. Effects of the cold pressor test on muscle sympathetic nerve activity in humans. Hypertension 1987;9:429.
22. Losordo DW, Kearney M, Kim EA, Jekanowski J, Isner JM. Variable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women. Circulation 1994;89:1501.
23. Post WS, Goldschmidt-Clermont PJ, Wilhide CC, et al. Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system. Cardiovasc Res 1999;43:985.
24. Angerer P, Stork S, Kothny W, Schmitt P, von Schacky C. Effect of oral postmenopausal hormone replacement on progression of atherosclerosis: A randomized, controlled trial. Arterioscl, Thromb Vascular Biol 2001;21:262.
25. Byington RP, Furberg CD, Herrington DM, et al. Effect of estrogen plus progestin on progression of carotid atherosclerosis in postmenopausal women with heart disease: HERS B-mode substudy. Arterioscl, Thromb, Vascular Biol 2002;22:1692.
26. Wu FC, von Eckardstein A. Androgens and coronary artery disease. Endocr Rev 2003;24:183.