Droperidol-induced proarrhythmia: The beginning of an answer?

Anesthesiology

Volumn 107, Issue 4, 2007, Pages 524-526

  Charbit, Beny ^a   Funck Brentano, Christian ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIEMETIC AGENT; DROPERIDOL; ONDANSETRON; PLACEBO; SETRON DERIVATIVE; TERFENADINE; UNCLASSIFIED DRUG;

CLINICAL TRIAL; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; DRUG WITHDRAWAL; EDITORIAL; ELECTROCARDIOGRAM; EPIDURAL ANESTHESIA; EPIDURAL HEMATOMA; FOOD AND DRUG ADMINISTRATION; HEART ARREST; HEART PROARRHYTHMIA; HUMAN; LOW DRUG DOSE; PRIORITY JOURNAL; QT PROLONGATION; SIDE EFFECT; SUDDEN DEATH; TORSADE DES POINTES; TREATMENT CONTRAINDICATION;

ADJUVANTS, ANESTHESIA; DROPERIDOL; ETHER-A-GO-GO POTASSIUM CHANNELS; HUMANS; LONG QT SYNDROME; POTASSIUM CHANNEL BLOCKERS; TORSADES DE POINTES; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 34748817466     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/01.anes.0000282093.29212.b6     Document Type: Editorial

References (12)

1. Gan TJ, Meyer T, Apfel CC, Chung F, Davis PJ, Eubanks S, Kovac A, Philip BK, Sessler DI, Temo J, Tramer MR, Watcha M: Consensus guidelines for managing postoperative nausea and vomiting. Anesth Analg 2003; 97:62-71
2. Nuttall GA, Eckerman KM, Jacob KA, Pawlaski EM, Wigersma SK, Shirk Marienau ME, Olivier WC, Narr BJ, Ackerman MJ: Does low-dose droperidol administration increase the risk of drug-induced QT prolongation and torsade de pointes in the general surgical population? ANESTHESIOLOGY 2007; 107:531-6
3. Roden DM: Drug-induced prolongation of the QT interval. N Engl J Med 2004; 350:1013-22
4. Drolet B, Zhang S, Deschenes D, Rail J, Nadeau S, Zhou Z, January CT, Turgeon J: Droperidol lengthens cardiac repolarization due to block of the rapid component of the delayed rectifier potassium current. J Cardiovasc Electrophysiol 1999; 10:1597-604
5. Schwoerer AP, Blutner C, Brandt S, Binder S, Siebrands CC, Ehmke H, Friederich P: Molecular interaction of droperidol with human ether-a-go-go-related gene channels: Prolongation of action potential duration without inducing early afterdepolarization. ANESTHESIOLOGY 2007; 106:967-76
6. White PF, Song D, Abrao J, Klein KW, Navarette B: Effect of low-dose droperidol on the QT interval during and after general anesthesia: A placebo-controlled study. ANESTHESIOLOGY 2005; 102:1101-5
7. Charbit B, Albaladejo P, Funck-Brentano C, Legrand M, Samain E, Marty J: Prolongation of QTc interval after postoperative nausea and vomiting treatment by droperidol or ondansetron. ANESTHESIOLOGY 2005; 102:1094-100
8. Pratt CM, Ruberg S, Morganroth J, McNutt B, Woodward J, Harris S, Ruskin J, Moye L: Dose-response relation between terfenadine (Seldane) and the QTc interval on the scalar electrocardiogram: Distinguishing a drug effect from spontaneous variability. Am Heart J 1996; 131:472-80
9. Woosley RL, Chen Y, Freiman JP, Gillis RA: Mechanism of the cardiotoxic actions of terfenadine. JAMA 1993; 269:1532-6
10. Hanrahan JP, Choo PW, Carlson W, Greineder D, Faich GA, Platt R: Terfenadine-associated ventricular arrhythmias and QTc interval prolongation: A retrospective cohort comparison with other antihistamines among members of a health maintenance organization. Ann Epidemiol 1995; 5:201-9
11. Kuryshev YA, Brown AM, Wang L, Benedict CR, Rampe D: Interactions of the 5-hydroxytryptamine 3 antagonist class of antiemetic drugs with human cardiac ion channels. J Pharmacol Exp Ther 2000; 295:614-20
12. Ruppen W, Derry S, McQuay H, Moore RA: Incidence of epidural hematoma, infection, and neurologic injury in obstetric patients with epidural analgesia/anesthesia. ANESTHESIOLOGY 2006; 105:394-9