Antithrombotic effect of a protein-type I class snake venom metalloproteinase, kistomin, is mediated by affecting glycoprotein Ib-von Willebrand factor interaction

Molecular Pharmacology

Volumn 72, Issue 4, 2007, Pages 984-992

  Hsu, Chun Chieh ^a   Wu, Wen Bin ^b   Chang, Ya Hui ^a   Kuo, Heng Lan ^a   Huang, Tur Fu ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORESCENT DYE; GLYCOPROTEIN IB; GLYCOPROTEIN IB ALPHA; KISTOMIN; METALLOPROTEINASE; RISTOCETIN; SNAKE VENOM; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLEEDING TIME; CONTROLLED STUDY; DRUG EFFECT; FLOW CYTOMETRY; FLUORESCENCE; HEMOSTASIS; MALE; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; STRUCTURE ACTIVITY RELATION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOSIS; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; ANTITHROMBINS; BASE SEQUENCE; CROTALID VENOMS; DNA PRIMERS; DNA, COMPLEMENTARY; HUMANS; MALE; METALLOPROTEASES; MICE; MICE, INBRED ICR; MOLECULAR SEQUENCE DATA; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; VON WILLEBRAND FACTOR;

EID: 34748815571     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.107.038018     Document Type: Article

References (24)

1. Andrews RK and Berndt MC (2004) Platelet physiology and thrombosis. Thromb Res 114:447-453.
2. Andrews RK, Gardiner EE, Shen Y, Whisstock JC, and Berndt MC (2003) Glycoprotein Ib-IX-V. Int J Biochem Cell Biol 35:1170-1174.
3. Berndt MC, Shen Y, Dopheide SM, Gardiner EE, and Andrews RK (2001) The vascular biology of the glycoprotein Ib-IX-V complex. Thromb Haemost 86:178-188.
4. Bonnefoy A, Vermylen J, and Hoylaerts MF (2003) Inhibition of von Willebrand factor-GPIb/IX/V interactions as a strategy to prevent arterial thrombosis. Expert Rev Cardiovasc Ther 1:257-269.
5. Canobbio I, Balduini C, and Torti M (2004) Signalling through the platelet glycoprotein Ib-V-IX complex. Cell Signal 16:1329-1344.
6. Chang MC and Huang TF (1994) In vivo effect of a thrombin-like enzyme on platelet plug formation induced in mesenteric microvessels of mice. Thromb Res 73:31-38.
7. Coller BS, Peerschke EI, Scudder LE, and Sullivan CA (1983) Studies with a murine monoclonal antibody that abolishes ristocetin-induced binding of von Willebrand factor to platelets: additional evidence in support of GPIb as a platelet receptor for von Willebrand factor. Blood 61:99-110.
8. Fox JW and Serrano SMT (2005) Structural considerations of the snake venom metalloproteinases, key members of the M12 reprolysin family of metalloproteinases. Toxicon 45:969-985.
9. Huang TF, Chang MC, and Teng CM (1993) Antiplatelet protease, kistomin, selectively cleaves human platelet glycoprotein Ib. Biochim Biophys Acta 1158:293-299.
10. Huang TF, Wu WJ, and Ouyang C (1987) Characterization of a potent platelet aggregation inhibitor for Agkistrodon rhodostoma snake venom. Biochim Biophys Acta 925:248-257.
11. Jackson SP and Schoenwaelder SM (2003) Antiplatelet therapy: in search of the 'magic bullet'. Nat Rev Drug Discov 2:775-789.
12. Kamiguti AS (2005) Platelets as targets of snake venom metalloproteinases. Toxicon 45:1041-1049.
13. Levy GG, Nichols WC, Lian EC, Foroud T, McClintick JN, McGee BM, Yang AY, Siemieniak DR, Stark KR, Gruppo R, et al. (2001) Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature 413:488-494.
14. Liu CZ, Hur BT, and Huang TF (1996) Measurement of glycoprotein IIb/IIIa blockade by flow cytometry with fluorescein isothiocyanate-conjugated crotavirin, a member of disintegrins. Thromb Haemost 76:585-591.
15. Marsh NA (2001) Diagnostic uses of snake venom. Haemostasis 31:211-217.
16. Matsui T, Fujimura Y, and Titani K (2000) Snake venom proteases affecting hemostasis and thrombosis. Biochim Biophys Acta 1477:146-156.
17. Paine MJ, Desmond HP, Theakston RD, and Crampton JM (1992) Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family. J Biol Chem 267:22869-22876.
18. Randolph A, Chamberlain SH, Chu HLC, Retzios AD, Markland FS Jr and Masiarz FR (1992) Amino acid sequence of fibrolase, a direct-acting fibrinolytic enzyme from Agkistrodon contortrix contortrix venom. Protein Sci 1:590-600.
19. Tseng YL, Lee CJ, and Huang TF (2004a) Effects of a snake venom metalloproteinase, triflamp, on platelet aggregation, platelet-neutrophil and neutrophil-neutrophil interactions: involvement of platelet GPIbalpha and neutrophil PSGL-1. Thromb Haemost 91:315-324.
20. Tseng YL, Wu WB, Hsu CC, Peng HC, and Huang TF (2004b) Inhibitory effects of human alpha2-macroglobulin and mouse serum on the PSGL-1 and glycoprotein Ib proteolysis by a snake venom metalloproteinase, triflamp. Toxicon 43:769-777.
21. Wang WJ and Huang TF (2001) A novel tetrameric venom protein, agglucetin from Agkistrodon acutus, acts as a glycoprotein Ib agonist. Thromb Haemost 86:1077-1086.
22. Ward CM, Andrews RK, Smith AI, and Berndt MC (1996) Mocarhagin, a novel cobra venom metalloproteinase, cleaves the platelet von Willebrand factor receptor glycoprotein Ibalpha. Identification of the sulfated tyrosine/anionic sequence Tyr-276-Glu-282 of glycoprotein Ibalpha as a binding site for von Willebrand factor and alpha-thrombin. Biochemistry 35:4929-4938.
23. Wu WB, Chang SC, Liau MY, and Huang TF (2001a) Purification, molecular cloning and mechanism of action of graminelysin I, a snake-venom-derived metalloproteinase that induces apoptosis of human endothelial cells. Biochem J 357:719-728.
24. Wu WB, Peng HC, and Huang TF (2001b) Crotalin, a vWF and GPIb cleaving metalloproteinase from venom of Crotalus atrox. Thromb Haemost 86:1501-1511.