Gonococcal transferrin binding protein chimeras induce bactericidal and growth inhibitory antibodies in mice

Vaccine

Volumn 25, Issue 41, 2007, Pages 7247-7260

  Price, Gregory A ^a   Masri, Heather P ^a   Hollander, Aimee M ^a   Russell, Michael W ^b   Cornelissen, Cynthia Nau ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

Cholera toxin; Iron; Neisseria gonorrhoeae; TonB dependent transporter; Vaccine

Indexed keywords

BACTERIAL VACCINE; BACTERIUM ANTIBODY; CHOLERA TOXIN; NEISSERIA GONORRHAEAE VACCINE; TRANSFERRIN BINDING PROTEIN A; TRANSFERRIN BINDING PROTEIN A LOOP 2 CHOLERA TOXIN FUSION PROTEIN; TRANSFERRIN BINDING PROTEIN B; TRANSFERRIN BINDING PROTEIN B CHOLERA TOXIN FUSION PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; CHIMERA; CONTROLLED STUDY; FEMALE; IMMUNOGENICITY; MOUSE; MOUSE STRAIN; NEISSERIA GONORRHOEAE; NEISSERIACEAE INFECTION; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL PROTEINS; CHOLERA TOXIN; DNA, BACTERIAL; FEMALE; GONORRHEA; MICE; MICROBIAL VIABILITY; MOLECULAR SEQUENCE DATA; NEISSERIA GONORRHOEAE; RECOMBINANT FUSION PROTEINS; SEQUENCE ANALYSIS, DNA; TRANSFERRIN-BINDING PROTEIN A; TRANSFERRIN-BINDING PROTEIN B; VAGINA;

EID: 34648843572     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2007.07.038     Document Type: Article

References (55)

1. Tapsall J. Antimicrobial resistance in Neisseria gonorrhoeae (2001), World Health Organization
2. Gerbase A.C., Rowley J.T., and Mertens T.E. Global epidemiology of sexually transmitted diseases. Lancet 351 Suppl. 3 (1998) 2-4
3. Centers for Disease Control and Prevention. Sexually transmitted disease surveillance, 2004. Atlanta, GA: U.S. Department of Health and Human Services; 2004.
4. Russell M.W., Sparling P.F., Morrison R.P., Cauci S., Fidel P.L., Martin D., et al. Mucosal immunology of sexually transmitted diseases. 3rd Ed. (2005), Elsevier/Academic Press, San Diego p. 1693-1720
5. Hook E.W.I., and Handsfield H.H. Gonococcal infections in the adult. 3rd Ed. (1999), McGraw-Hill, New York p. 451-66
6. Centers for Disease Control and Prevention. Sexually transmitted disease surveillance 2003 supplement: gonococcal isolate surveillance project (GISP) annual report 2003. Atlanta, GA: U.S. Department of Health and Human Services; 2003.
7. Cohen M.S., Hoffman I.F., Royce R.A., Kazembe P., Dyer J.R., Daly C.C., et al. Reduction of concentration of HIV-1 in semen after treatment of urethritis: implications for prevention of sexual transmission of HIV-1. AIDSCAP Malawi Research Group. Lancet 349 9069 (1997) 1868-1873
8. McClelland R.S., Wang C.C., Mandaliya K., Overbaugh J., Reiner M.T., Panteleeff D.D., et al. Treatment of cervicitis is associated with decreased cervical shedding of HIV-1. Aids 15 1 (2001) 105-110
9. Boslego J.W., Tramont E.C., Chung R.C., McChesney D.G., Ciak J., Sadoff J.C., et al. Efficacy trial of a parenteral gonococcal pilus vaccine in men. Vaccine 9 3 (1991) 154-162
10. Greenberg L., Diena B.B., Ashton F.A., Wallace R., Kenny C.P., Znamirowski R., et al. Gonococcal vaccine studies in Inuvik. Can J Public Health 65 1 (1974) 29-33
11. Tramont E.C. Gonococcal vaccines. Clin Microbiol Rev 2 Suppl. (1989) S74-S77
12. Cornelissen C.N., Anderson J.E., Boulton I.C., and Sparling P.F. Antigenic and sequence diversity in gonococcal transferrin-binding protein A. Infect Immun 68 8 (2000) 4725-4735
13. Cornelissen C.N., Anderson J.E., and Sparling P.F. Characterization of the diversity and the transferrin-binding domain of gonococcal transferrin-binding protein 2. Infect Immun 65 2 (1997) 822-828
14. Lissolo L., Maitre-Wilmotte G., Dumas P., Mignon M., Danve D., and Quentin-Millet M.-J. Evaluation of transferrin-binding protein 2 within the transferrin-binding complex as a potential antigen for future meningococcal vaccines. Infect Immun 63 3 (1995) 884-890
15. Pintor M., Ferron L., Gomez J.A., Powell N.B., Ala'Aldeen D.A., Borriello S.P., et al. Blocking of iron uptake from transferrin by antibodies against the transferrin binding proteins in Neisseria meningitidis. Microb Pathog 20 3 (1996) 127-139
16. West D., Reddin K., Matheson M., Heath R., Funnell S., Hudson M., et al. Recombinant Neisseria meningitidis transferrin binding protein A protects against experimental meningococcal infection. Infect Immun 69 3 (2001) 1561-1567
17. Stevenson P., Williams P., and Griffiths E. Common antigemic domains in transferrin-binding protein 2 of Neisseria meningitidis, Neisseria gonorrhoeae, and Haemophilus influenzae Type b. Infect Immun 60 6 (1992) 2391-2396
18. Cornelissen C.N., Kelley M., Hobbs M.M., Anderson J.E., Cannon J.G., Cohen M.S., et al. The transferrin receptor expressed by gonococcal strain FA1090 is required for the experimental infection of human male volunteers. Mol Microbiol 27 3 (1998) 611-616
19. Price G.A., Russell M.W., and Cornelissen C.N. Intranasal administration of recombinant Neisseria gonorrhoeae transferrin binding proteins A and B conjugated to the cholera toxin B subunit induces systemic and vaginal antibodies in mice. Infect Immun 73 7 (2005) 3945-3953
20. Hajishengallis G., Arce S., Gockel C.M., Connell T.D., and Russell M.W. Immunomodulation with enterotoxins for the generation of secretory immunity or tolerance: applications for oral infections. J Dent Res 84 12 (2005) 1104-1116
21. De Haan L., and Hirst T.R. Cholera toxin: a paradigm for multi-functional engagement of cellular mechanisms (review). Mol Membr Biol 21 2 (2004) 77-92
22. Hardy S.J., Holmgren J., Johansson S., Sanchez J., and Hirst T.R. Coordinated assembly of multisubunit proteins: oligomerization of bacterial enterotoxins in vivo and in vitro. Proc Natl Acad Sci USA 85 19 (1988) 7109-7113
23. Hajishengallis G., Hollingshead S.K., Koga T., and Russell M.W. Mucosal immunization with a bacterial protein antigen genetically coupled to cholera toxin A2/B subunits. J Immunol 154 9 (1995) 4322-4332
24. Lee S.F., Halperin S.A., Salloum D.F., MacMillan A., and Morris A. Mucosal immunization with a genetically engineered pertussis toxin S1 fragment-cholera toxin subunit B chimeric protein. Infect Immun 71 4 (2003) 2272-2275
25. Li X., Erbe J.L., Lockatell C.V., Johnson D.E., Jobling M.G., Holmes R.K., et al. Use of translational fusion of the MrpH fimbrial adhesin-binding domain with the cholera toxin A2 domain, coexpressed with the cholera toxin B subunit, as an intranasal vaccine to prevent experimental urinary tract infection by Proteus mirabilis. Infect Immun 72 12 (2004) 7306-7310
26. Martin M., Hajishengallis G., Metzger D.J., Michalek S.M., Connell T.D., and Russell M.W. Recombinant antigen-enterotoxin A2/B chimeric mucosal immunogens differentially enhance antibody responses and B7-dependent costimulation of CD4(+) T cells. Infect Immun 69 1 (2001) 252-261
27. Sheoran A.S., Artiushin S., and Timoney J.F. Nasal mucosal immunogenicity for the horse of a SeM peptide of Streptococcus equi genetically coupled to cholera toxin. Vaccine 20 11-12 (2002 Feb 22) 1653-1659
28. Sultan F., Jin L.L., Jobling M.G., Holmes R.K., and Stanley Jr. S.L. Mucosal immunogenicity of a holotoxin-like molecule containing the serine-rich Entamoeba histolytica protein (SREHP) fused to the A2 domain of cholera toxin. Infect Immun 66 2 (1998 Feb) 462-468
29. Singh S.R., Hulett K., Pillai S.R., Dennis V.A., Oh M.K., and Scissum-Gunn K. Mucosal immunization with recombinant MOMP genetically linked with modified cholera toxin confers protection against Chlamydia trachomatis infection. Vaccine 24 8 (2006 Feb 20) 1213-1224
30. Kellogg Jr. D.S., Peacock Jr. W.L., Deacon W.E., Brown L., and Pirkle C.I. Neisseria gonorrhoeae. I. Virulence genetically linked to clonal variation. J Bacteriol 85 (1963) 1274-1279
31. West S.E.H., and Sparling P.F. Aerobactin utilization by Neisseria gonorrhoeae and cloning of a genomic DNA fragment that complements Escherichia coli fhuB mutations. J Bacteriol 169 8 (1987) 3414-3421
32. Masri H.P., and Cornelissen C.N. Specific ligand binding attributable to individual epitopes of gonococcal transferrin binding protein A. Infect Immun 70 2 (2002) 732-740
33. Price G.A., Hobbs M.M., and Cornelissen C.N. Immunogenicity of gonococcal transferrin binding proteins during natural infections. Infect Immun 72 1 (2004 January 1) 277-283
34. Rosenthal K.L., and Gallichan W.S. Challenges for vaccination against sexually transmitted diseases: induction and long-term maintenance of mucosal immune responses in the female genital tract. Semin Immunol 9 5 (1997) 303-314
35. Yost-Daljev M.K., and Cornelissen C.N. Determination of surface-exposed, functional domains of gonococcal transferrin-binding protein A. Infect Immun 72 3 (2004) 1775-1785
36. Snyder L.A., Davies J.K., and Saunders N.J. Microarray genomotyping of key experimental strains of Neisseria gonorrhoeae reveals gene complement diversity and five new neisserial genes associated with Minimal Mobile Elements. BMC Genomics 5 1 (2004) 23
37. Jordan P.W., Snyder L.A., and Saunders N.J. Strain-specific differences in Neisseria gonorrhoeae associated with the phase variable gene repertoire. BMC Microbiol 5 1 (2005) 21
38. Jobling M.G., Palmer L.M., Erbe J.L., and Holmes R.K. Construction and characterization of versatile cloning vectors for efficient delivery of native foreign proteins to the periplasm of Escherichia coli. Plasmid 38 3 (1997) 158-173
39. Retzer M.D., Yu R.H., and Schryvers A.B. Identification of sequences in human transferrin that bind to the bacterial receptor protein, transferrin-binding protein B. Mol Microbiol 32 1 (1999) 111-121
40. Matoba N., Magerus A., Geyer B.C., Zhang Y., Muralidharan M., Alfsen A., et al. A mucosally targeted subunit vaccine candidate eliciting HIV-1 transcytosis-blocking Abs. Proc Natl Acad Sci USA 101 37 (2004) 13584-13589
41. Russell M.W., and Mestecky J. Humoral immune responses to microbial infections in t he genital tract. Microbes Infect 4 6 (2002) 667-677
42. Anderson J.E., Sparling P.F., and Cornelissen C.N. Gonococcal transferrin-binding protein 2 facilitates but is not essential for transferrin utilization. J Bacteriol 176 11 (1994) 3162-3170
43. Legrain M., Mazarin V., Irwin S.W., Bouchon B., Quentin-Millet M.J., Jacobs E., et al. Cloning and characterization of Neisseria meningitidis genes encoding the transferrin-binding proteins Tbp1 and Tbp2. Gene 130 1 (1993) 73-80
44. Norheim G., Aase A., Caugant D.A., Hoiby E.A., Fritzsonn E., Tangen T., et al. Development and characterisation of outer membrane vesicle vaccines against serogroup A Neisseria meningitidis. Vaccine 23 29 (2005) 3762-3774
45. Boulton I.C., Yost M.K., Anderson J.E., and Cornelissen C.N. Identification of discrete domains within gonococcal transferrin-binding protein A that are necessary for ligand binding and iron uptake functions. Infect Immun 68 12 (2000) 6988-6996
46. Oakhill J.S., Sutton B.J., Gorringe A.R., and Evans R.W. Homology modelling of transferrin-binding protein A from Neisseria meningitidis. Protein Eng Design Select 18 5 (2005) 221-228
47. Gorringe A.R., Borrow R., Fox A.J., and Robinson A. Human antibody response to meningococcal transferrin binding proteins: evidence for vaccine potential. Vaccine 13 13 (1995) 1207-1212
48. Sadler K., Zeng W., and Jackson D.C. Synthetic peptide epitope-based polymers: controlling size and determining the efficiency of epitope incorporation. J Pept Res 60 3 (2002) 150-158
49. Carbonetti N., Simnad V., Elkins C., and Sparling P.F. Construction of isogenic gonococci with variable porin structure: effects on susceptibility to human serum and antibiotics. Mol Microbiol 4 6 (1990) 1009-1018
50. Jerse A.E. Experimental gonococcal genital tract infection and opacity protein expression in estradiol-treated mice. Infect Immun 67 11 (1999) 5699-5708
51. Maniatis T., Fritsch E.F., and Sambrook J. Molecular cloning: a laboratory manual (1982), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
52. Kenney C.D., and Cornelissen C.N. Demonstration and characterization of a specific interaction between gonococcal transferrin binding protein A and TonB. J Bacteriol 184 22 (2002) 6138-6145
53. Mickelsen P.A., and Sparling P.F. Ability of Neisseria gonorrhoeae, Neisseria meningitidis, and commensal Neisseria species to obtain iron from transferrin and iron compounds. Infect Immun 33 2 (1981) 555-564
54. Meyer T.F., Mlawer N., and So M. Pilus expression in Neisseria gonorrhoeae involves chromosomal rearrangement. Cell 30 1 (1982) 45-52
55. Cohen M.S., Cannon J.G., Jerse A.E., Charniga L.M., Isbey S.F., and Whicker L.G. Human experimentation with Neisseria gonorrhoeae: Rationale, methods, and implications for the biology of infection and vaccine development. J Infect Dis 169 (1994) 532-537