CDK11p58 protein kinase activity is associated with Bcl-2 down-regulation in pro-apoptosis pathway

Molecular and Cellular Biochemistry

Volumn 304, Issue 1-2, 2007, Pages 213-218

  Yun, Xiaojing ^a   Wu, Yihong ^a   Yao, Luyang ^a   Zong, Hongliang ^a   Hong, Yi ^a   Jiang, Jianhai ^a   Yang, Junwu ^a   Zhang, Zhou ^a   Gu, Jianxin ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Apoptosis; Bcl 2; CDK11p58; Cycloheximide (CHX); SMMC 7721hepatocarcinoma cells

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 11; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; PROTEIN P58; SERINE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

APOPTOSIS; CARCINOMA; CYCLIN-DEPENDENT KINASES; CYCLOHEXIMIDE; DOWN-REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, BCL-2; HUMANS; LIVER NEOPLASMS; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 34648843373     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-007-9502-x     Document Type: Article

References (33)

1. Ellis RE, Yuan JY, Horvitz HR (1991) Mechanisms and functions of cell death. Annu Rev Cell Biol 7:663-698
2. Williams GT, Smith CA (1993) Molecular regulation of apoptosis: Genetic controls on cell death. Cell 74:777-779
3. Ashkenazi A, Dixit VM (1998) Death receptors: Signaling and modulation. Science 281:1305-1308
4. Evan G, Littlewood T (1998) A matter of life and cell death. Science 281:1317-1322
5. Adams JM, Cory S (1998) The Bcl-2 protein family: Arbiters of cell survival. Science 281:1322-1326
6. Oltvai ZN, Milliman CL, Korsmeyer SJ (1993) Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619
7. Li P, Nijhawan D, Budihardjo I et al (1997) Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 91:479-489
8. Zou H, Henzel WJ, Liu X et al (1997) Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c -dependent activation of caspase-3. Cell 90:405-413
9. Breitschopf K, Haendeler J, Malchow P et al (2000) Prottranslational modification of Bcl-2 facilitates its proteasome-dependent degradation: molecular characterization of the involved signaling pathway. Mol Cell Biol 20:1886-1896
10. Ito T, Deng X, Carr B et al (1997) Bcl-2 phosphorylation required for anti-apoptosis function. J Biol Chem 272:11671-11673
11. Weil M, Jacobson MD, Coles HS et al (1996) Constitutive expression of the machinery for programmed cell death. J Cell Biol 133:1053-1059
12. Shi L, Nishioka WK, Th'ng J et al (1994) Premature p34cdc2 activation required for apoptosis. Science 263:1143-1145
13. Weinberg RA (1995) The retinoblastoma protein and cell cycle control. Cell 81:323-330
14. Lahti JM, Xiang J, Heath LS et al (1995) PITSLRE protein kinase activity is associated with apoptosis. Mol Cell Biol 15:1-11
15. Cai MM, Zhang SW, Zhang S et al (2002) Different effects of p58PITSLRE on the apoptosis induced by etoposide, cycloheximide and serum-withdrawal in human hepatocarcinoma cells. Mol Cell Biochem 238:49-55
16. Zhang S, Cai M, Zhang S et al (2002) Interaction of p58(PITSLRE), a G2/ M-specific protein kinase, with cyclin D3. J Biol Chem 277:35314-35322
17. Tan KO, Tan KM, Chan SL et al (2001) MAP-1, a novel proapoptotic protein containing a BH3-like motif that associates with Bax through its Bcl-2 homology domains. J Biol Chem 276:2802-2807
18. Li Z, Wang H, Zong H et al (2005) Downregulation of beta1,4-galactosyltransferase 1 inhibits CDK11(p58)-mediated apoptosis induced by cycloheximide. Biochem Biophys Res Commun 327:628-636
19. Yin XM, Oltvai ZN, Korsmeyer SJ (1994) BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 369:321-323
20. Tschopp J, Thome M, Hofmann K et al (1998) The fight of viruses against apoptosis. Curr Opin Genet Dev 8:82-87
21. Yang E, Zha J, Jockel J et al (1995) Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 80:285-291
22. Sawada M, Nakashima S, Banno Y et al (2006) Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptosis pathway in glioma cells. Oncogene 25:7440
23. Armstrong RC, Aja T, Xiang J et al (1996) Fas-induced activation of the cell death-related protease CPP32 Is inhibited by Bcl-2 and by ICE family protease inhibitors. J Biol Chem 271:16850-16855
24. Lamothe B, Aggarwal BB (2002) Ectopic expression of Bcl-2 and Bcl-xL inhibits apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL) through suppression of caspases-8, 7, and 3 and BID cleavage in human acute myelogenous leukemia cell line HL-60. J Interferon Cytokine Res 22:269-279
25. Cornelis S, Bruynooghe Y, Denecker G et al (2000) Identification and characterization of a novel cell cycle-regulated internal ribosome entry site. Mol Cell 5:597-605
26. Xiang J, Lahti JM, Grenet J et al (1994) Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms. J Biol Chem 269:15786-15794
27. Zong H, Li Z, Liu L et al (2005) Cyclin-dependent kinase 11(p58) interacts with HBO1 and enhances its histone acetyltransferase activity. FEBS Lett 579:3579-3588
28. Hockenbery D, Nunez G, Milliman C et al (1990) Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348:334-336
29. Zhu W, Cowie A, Wasfy GW et al (1996) Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types. Embo J 15:4130-4141
30. Jin Z, May WS, Gao F et al (2006) Bcl2 suppresses DNA repair by enhancing c-Myc transcriptional activity. J Biol Chem 281:14446-14456
31. Beyaert R, Kidd VJ, Cornelis S et al (1997) Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor. J Biol Chem 272:11694-11697
32. Chen C, Yan J, Sun Q et al (2006) Induction of apoptosis by p110C requires mitochondrial translocation of the proapoptotic BCL-2 family member BAD. FEBS Lett 580:813-821
33. Thomas A, Giesler T, White E (2000) p53 mediates bcl-2 phosphorylation and apoptosis via activation of the Cdc42/JNK1 pathway. Oncogene 19:5259-5269