Lymphocyte reconstitution after allogeneic bone marrow transplantation in a previously thymectomized patient - No evidence of extrathymic T-cell maturation [3]

Bone Marrow Transplantation

Volumn 40, Issue 7, 2007, Pages 705-706

  Giebel, S ^a   Dziaczkowska, J ^a   Wysoczanska, B ^b   Wojnar, J ^a   Krawczyk Kulis, M ^a   Lange, A ^b,c   Holowiecki, J ^a  

^a MEDICAL UNIVERSITY OF SILESIA   (Poland)

^b INSTITUTE OF IMMUNOLOGY AND EXPERIMENTAL THERAPY   (Poland)

^c Lower Silesian Centre for Cellular Transplantation   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; ANTINEOPLASTIC AGENT; BUSULFAN; CD4 ANTIGEN; CD45RA ANTIGEN; CD8 ANTIGEN; CYCLOPHOSPHAMIDE; CYCLOSPORIN; METHOTREXATE; THYMOCYTE ANTIBODY;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; CASE REPORT; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CHIMERA; GRAFT VERSUS HOST REACTION; HERPES ZOSTER; HLA MATCHING; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; IMMUNOSUPPRESSIVE TREATMENT; LETTER; LEUKEMIA REMISSION; LYMPHOCYTE DEPLETION; LYMPHOCYTE SUBPOPULATION; MALE; NATURAL KILLER CELL; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; T LYMPHOCYTE; THYMECTOMY; THYMOMA;

ADULT; BONE MARROW TRANSPLANTATION; GRAFT VS HOST DISEASE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LEUKEMIA, LYMPHOCYTIC, ACUTE; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MALE; T-LYMPHOCYTES; THYMECTOMY; THYMOMA; THYMUS GLAND; THYMUS NEOPLASMS; TRANSPLANTATION, HOMOLOGOUS; TREATMENT OUTCOME;

EID: 34648841030     PISSN: 02683369     EISSN: 14765365     Source Type: Journal    
DOI: 10.1038/sj.bmt.1705794     Document Type: Letter

References (10)

1. Douek DC, McFarland RD, Keiser PH, Gage EA, Massey JM, Haynes BF et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998; 396: 690-695.
2. Lundqvist C, Baranov V, Hammarstrom S, Athlin L, Hammarstrom ML. Intra-epithelial lymphocytes: Evidence for regional specialization and extrathymic T cell maturation in the human gut epithelium. Int Immunol 1995; 7: 1473.
3. Lynch S, Kelleher D, McManus R, O'Farrelly C. RAG1 and RAG2 expression in human intestinal epithelium: Evidence of extrathymic T cell differentiation. Eur J Immunol 1995; 25: 1143.
4. Bas A, Hammarstrom S, Hammarstrom M-L. Extrathymic TCR gene rearrangement in human small intestine: Identification of new splice forms of recombination activating gene-1 mRNA with selective tissue expression. J Immunol 2003; 171: 3359-3371.
5. Patel DD, Gooding ME, Parrott RE, Curtis KM, Haynes BF, Buckley RH. Thymic function after hematopoietic stem-cell transplantation for the treatment of severe combined immunodeficiency. N Eng J Med 2000; 342: 1325.
6. Mackall CL, Granger L, Sheard MA, Cepeda R, Gress RE. T cell regeneration after bone marrow transplantation: Differential CD45 isoform expression on thymic-derived versus thymic independent progeny. Blood 1993; 82: 2585-2594.
7. Hazenberg MD, Otto SA, de Pauw ES, Roelofs H, Fibbe WE, Hamann D et al. T cell receptor excision circle and T cell dynamics after allogeneic stem cell transplantation are related to clinical events. Blood 2002; 99: 3449-3452.
8. Heitger A, Greinix H, Mannhalter C, Mayerl D, Kern H, Eder J et al. Requirement of residual thymus to restore normal T cell subsets after human allogeneic bone marrow transplantation. Transplantation 2000; 69: 2366-2373.
9. Watanabe N, De Rosa SC, Cmelak A, Hoppe R, Herzenberg LA, Roederer M. Long-term depletion of naive T cells in patients treated for Hodgkin's disease. Blood 1997; 90: 3662-3672.
10. Faint JM, Annels NE, Carnow SJ, Shields P, Pilling D, Hislop AD et al. Memory T cells constitute a subset of the human CD8 + CD45RA + pool with distinct phenotypic and migratory characteristics. J Immunol 2001; 167: 212-220.