Decreased cardiac uptake of MIBG is a potential biomarker for the presence of Lewy bodies

Journal of Neurology

Volumn 254, Issue SUPPL. 4, 2007, Pages

  Orimo, Satoshi ^a,c   Amino, Takeshi ^b   Uchihara, Toshiki ^c   Mori, Fumiaki ^d   Kakita, Akiyoshi ^e   Wakabayashi, Koichi ^d   Takahashi, Hitoshi ^e  

^a Mutual Aid Association of Public School Teachers   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^d HIROSAKI UNIVERSITY   (Japan)

^e NIIGATA UNIVERSITY   (Japan)

Author keywords

Cardiac sympathetic denervation; Dementia with Lewy bodies; Lewy bodies; Meta iodobenzylguanidine (MIBG); Parkinson's disease

Indexed keywords

(3 IODOBENZYL)GUANIDINE; BIOLOGICAL MARKER;

ALZHEIMER DISEASE; ANATOMY; AUTONOMIC DYSFUNCTION; CELL LOSS; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; CORTICOBASAL DEGENERATION; DEMENTIA; DRUG UPTAKE; HEART DENERVATION; HEART SCINTISCANNING; HUMAN; LEWY BODY; LIFE; MYOCARDIAL SCINTIGRAPHY; NERVE CELL; NERVE DEGENERATION; PARKINSON DISEASE; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; SHY DRAGER SYNDROME; SYMPATHETIC GANGLION; SYMPATHETIC NERVE;

EID: 34648836076     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-007-4005-y     Document Type: Conference Paper

References (37)

1. Amino T, Orimo S, Ihoh Y, Takahashi A, Uchihara T, Mizusawa H (2005) Profound cardiac sympathetic denervation occurs in Parkinson disease. Brain Pathol 15:29-34
2. Bloch A, Probst A, Bissig H, Adams H, Tolnay M (2006) α-Synuclein pathology of the spinal and peripheral autonomic nervous system in neurologically unimpaired elderly subjects. Neuropathol Appl Neurobiol 32:284-295
3. 123I]MIBG separates Parkinson's disease from multiple system atrophy. Neurology 53:1020-1025
4. Druschky A, Hilz MJ, Platsch G, Radespiel-Tröger M, Druschky K, Kuwert T, Neundörfer B (2000) Differentiation of Parkinson's disease and multiple system atrophy in early disease by means of I-123-MIBG-SPECTJ Neurol Sci 175:3-12
5. Goldstein DS, Holmes C, Cannon RO III, Eisenhofer G, Kopin IJ (1997) Sympathetic cardioneuropathy in dysautonomias. N Engl J Med 336:696-702
6. Goldstein DS, Holmes C, Li S-T, Bruce S, Metman LV, Cannon RO III (2000) Cardiac sympathetic denervation in Parkinson disease. Ann Intern Med 133:338-347
7. 123I]iodobenzylguanidine in neurological patients with autonomic failure. J Auton Nerv Syst 49:81-84
8. 123IMIBG uptake in Parkinson's disease. J Neurol Neurosurg Psychiatry 74:423-426
9. Iwanaga K, Wakabayashi K, Yoshimoto M, Tomita I, Satoh H, Takashima H, Satoh A, Seto M, Tsujihata M, Takahashi H (1999) Lewy body-type degeneration in cardiac plexus in Parkinson's and incidental Lewy body diseases. Neurology 52:1269-1271
10. Kawano H, Okada R,Yano K (2003) Histological study on the distribution of autonomic nerves in the human heart. Heart Vessels 18:32-39
11. Merlet P, Valette H, Dubobis-Randé J-L, Moyse D, Duboc D, Dove P, Bourguignon MH, Benvenuti C, Duval AM, Agnosti D, Loisance D, Castaigne A, Syrota A (1992) Prognostic value of cardiac metaiodobenzylguanidine imaging in patients with heart failure. J Nucl Med 33:471-477
12. 123I-MIBG uptake and increased clearance in various cardiac diseases. Nucl Med Commun 15:317-323
13. Orimo S (2006) Parkinson's disease. Laboratory findings. SAISHIN IGAKU (in Japanese) Suppl. 72-80
14. Orimo S (2006) Degeneration of cardiac sympathetic nerve in Parkinson's disease. Clin Neuroscience (in Japanese) 24:502-503
15. Orimo S, Amino T, Ito Y, Takahashi A, Kojo T, Uchihara T, Tsuchiya K, Mori F, Wakabayashi K, Takahashi H (2005) Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease. Acta Neuropathol (Berl) 109:583-588
16. Orimo S, Takahashi A, Uchihara T, Mori F, Kakita A, Wakabayashi K, Takahashi H (2007) Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease. Brain Pathol 17:24-30
17. Orimo S, Amino T, Yokochi M, Kojo T, Uchihara T, Takahashi A, Wakabayashi K, Takahashi H, Hattori N, Mizuno Y (2005) Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2. Mov Disord 20:1350-1353
18. Orimo S, Kanazawa T, Amino T, Takahashi A, Kojo T, Uchihara T, Kakita A, Wakabayashi K, Takahashi H (2006) Difference of degenerating process between myelinated and unmyelinated fibers of cardiac nerve in Parkinson's disease. Neuropathology 26:A4
19. Orimo S, Kanazawa T, Nakamura A, Uchihara T, Mori F, Kakita A, Wakabayashi K, Takahashi H (2007) Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy. Acta Neuropathol (Berl) 113:81-86
20. Orimo S, Oka T, Miura H, Tsuchiya K, Mori F, Wakabayashi K, Nagao T, Yokochi M (2002) Sympathetic cardiac denervation in Parkinson's disease and pure autonomic failure but not in multiple system atrophy. J Neurol Neurosurg Psychiatry 73:776-777
21. 123I]meta-iodobenzylguanidine myocardial scintigraphy differentiates corticobasal degeneration from Parkinson's disease. Intern Med 42:127-128
22. 123I-metaiodobenzylguanidine myocardial scintigraphy in Parkinson's disease. J Neurol Neurosurg Psychiatry 67:189-194
23. Orimo S, Ozawa E, Oka T, Nakade S, Tsuchiya K, Yoshimoto M, Wakabayashi K, Takahashi H (2001) Different histopathology accounting for a decrease in myocardial MIBG uptake in PD and MSA. Neurology 57:1140-1141
24. Owman C (1988) Autonomic innervation of the cardiovascular system. In: Bjorklund A, Hokfelt T, Owman C (eds) Handbook of chemical neuroanatomy. Elsevier, Amsterdam, pp 327-389
25. Rabinovitch MA, Rose CP, Schwab AJ, Fitchett DH, Honos GN, Stewart JA, Chen LF, Castilla EP, Gomez AA, Abrahamowicz M (1993) A method of dynamic analysis of iodine-123-metaiodobenzylguanidine scintigrams in cardiac mechanical overload hypertrophy and failure. J Nucl Med 34:589-600
26. 123I-MIBG uptake by the heart in Parkinson's disease: assessment of cardiac sympathetic denervation and diagnostic value. J Nucl Med 40:371-375
27. Schofer J, Spielmann R, Schuchert A, Weber K, Schlüter M (1988) Iodine-123 meta-iodobenzylguanidine scintigraphy: A noninvasive method to demonstrate myocardial adrenergic nervous system disintegrity in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 12:1252-1258
28. Stanton MS, Tuli MM, Radtke NL, Heger JJ, Miles WM, Mock BH, Burt RW, Wellman HN, Zipes DP (1989) Regional sympathetic denervation after myocardial infarction in humans detected noninvasively using I-123 metaiodobenzylguanidine. J Am Coll Cardiol 14:1519-1526
29. 123I- metaiodobenzylguanidine uptake in autosomal recessive juvenile parkinsonism: first case report. Mov Disord 20:634-636
30. Taki J, Nakajima K, Hwang E-H, Matsunari I, Komai K, Yoshita M, Sakajiri K, Tonami N (2000) Peripheral sympathetic dysfunction in patients with Parkinson's disease without autonomic failure is heart selective and disease specific. Eur J Nucl Med 27:566-573
31. 123I-MIBG scintigraphy as a pathophysiological indicator in the assessment of Parkinson's disease and related disorders: it can be a specific marker for Lewy body disease. Ann Nucl Med 18:453-461
32. Wakabayashi K, Takahashi H, Ohama E, Takeda S, Ikuta F (1993) Lewy bodies in the visceral autonomic nervous system in Parkinson's disease. In: Narabayashi H, Nagatsu N, Yanagisawa N, Mizuno Y (eds) Advances in neurology. Lippincott-Raven, New York, pp 609-612
33. 123I-metaiodobenzylguanidine (MIBG) uptake in dementia with Lewy bodies: comparison with Alzheimer's disease. J Neurol Neurosurg Psychiatry 70:781-783
34. 131I]iodobenzylguanidine. J Nucl Med 21:349-353
35. 123I-MIBG scintigraphy in pure progressive autonomic failure. Eur Neurol 38:291-296
36. Yoshita M (1998) Differentiation of idiopathic Parkinson's disease from striatonigral degeneration and progressive supranuclear palsy using iodine-123 meta-iodobenzylguanidine myocardial scintigraphy. J Neurol Sci 155:60-67
37. 123I]MIBG myocardial scintigraphy in the distinction between dementia of the Alzheimer' stype and dementia with Lewy bodies. J Neurol Neurosurg Psychiatry 71:583-588