A new, one-pot, three-component synthesis of 4H-pyrido[1,2-a]pyrimidines, 4H-pyrimido[1,2-a]pyrimidines, and 4H-pyrazino[1,2-a]pyrimidines

Tetrahedron

Volumn 63, Issue 45, 2007, Pages 11135-11140

  Adib, Mehdi ^a   Hosein Sayahi, Mohammad ^a   Ziyadi, Hakimeh ^a   Bijanzadeh, Hamid Reza ^b   Zhu, Long Guan ^c  

^a UNIVERSITY OF TEHRAN   (Iran)

^b TARBIAT MODARES UNIVERSITY   (Iran)

^c ZHEJIANG UNIVERSITY   (China)

Author keywords

4H Pyrazino 1,2 a pyrimidines; 4H Pyrido 1,2 a pyrimidines; 4H Pyrimido 1,2 a pyrimidines; Acetylenic esters; Isocyanides; Three component synthesis

Indexed keywords

ACETYLENE DERIVATIVE; AMIDE; AMPHOLYTE; DICARBOXYLIC ACID; IMINE; PYRIMIDINE DERIVATIVE;

ADDITION REACTION; ARTICLE; CHEMICAL REACTION KINETICS; CHEMICAL STRUCTURE; CYCLIZATION; ONE POT SYNTHESIS; PRIORITY JOURNAL; QUANTUM YIELD; STEREOCHEMISTRY; X RAY CRYSTALLOGRAPHY;

EID: 34648820644     PISSN: 00404020     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tet.2007.08.024     Document Type: Article

References (24)

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24. 2 at -5 °C over 2-3 min. The reaction mixture was stirred for 15 min and then warmed up to room temperature and stirred for 2 h. Then, the solvent was evaporated to 20 mL. The chloride salt was separated by suction and filtration. The filtrate was washed with water (2×30 mL) and dried over anhydrous sodium sulfate. The solvent was removed and the N-(2-heteroaryl)amide was obtained as colorless crystals.