Drug solubility in phospholipid carrier as a predictive parameter for drug recovery in microparticles produced by the aerosol solvent extraction system (ASES) process

Drug Development and Industrial Pharmacy

Volumn 33, Issue 9, 2007, Pages 932-944

  Sarisuta, Narong ^a   Kunastitchai, Sarinnate ^a,b   Pichert, Lars ^b   Müller, Bernd W ^b  

^a MAHIDOL UNIVERSITY   (Thailand)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

Aerosol solvent extraction system; Drug solubility; Microparticles; Phospholipid; Supercritical carbon dioxide

Indexed keywords

BETAMETHASONE VALERATE; CHLORAMPHENICOL; CHOLESTEROL; DIAZEPAM; DRUG CARRIER; LIPID; MICONAZOLE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID;

ADVERSE OUTCOME; AEROSOL; ANALYTICAL PARAMETERS; ARTICLE; CORRELATION ANALYSIS; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SOLUBILITY; FILM; GAS; PREDICTOR VARIABLE; SOLVENT EXTRACTION; X RAY POWDER DIFFRACTION;

AEROSOLS; BETAMETHASONE 17-VALERATE; CALORIMETRY, DIFFERENTIAL SCANNING; CHLORAMPHENICOL; CHOLESTEROL; DIAZEPAM; DRUG CARRIERS; FORECASTING; HEAT; MICONAZOLE; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; PHOSPHATIDYLCHOLINES; PHOSPHOLIPIDS; SOLUBILITY; SOLVENTS; X-RAY DIFFRACTION;

EID: 34648818909     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.1080/03639040601128670     Document Type: Article

References (19)

1. Badens, E., Magnan, C., & Charbit, G. (2001). Microparticles of soy lecithin formed by supercritical processes. Biotech. Bioeng., 72(2), 194-204.
2. Bleich, J., & Müller, B. W. (1996). Production of drug loaded microparticles by the use of supercritical gases with aerosol solvent extraction system (ASES) process. J. Microencapsul., 13(2), 131-139.
3. Bleich, J., Müller, B. W., & Waßmus, W. (1993). Aerosol solvent extraction system - a new microparticle production technique. Int. J. Pharm., 97, 111-117.
4. Bodmeier, R., Wang, H., Dixon, D. J., Mawson, S., & Johnston, K. P. (1995). Polymeric microspheres prepared by spraying into compressed carbon dioxide. Pharm. Res., 12(8), 1211-1217.
5. Engwicht, A., Girreser, U., & Müller, B. W. (2000). Characterization of copolymers of lactic and glycolic acid for supercritical fluid processing. Biomaterials, 21, 1587-1593.
6. Jenquin, M. R., & McGinity, J. W. (1994). Characterization of acrylic resin matrix films and mechanisms of drug-polymer interactions. Int. J. Pharm., 101, 23-34.
7. Kerč, J., Srčič, S., Knez, Ž., & Sencar-Božič, P. (1999). Micronization of drugs using supercritical carbon dioxide. Int. J. Pharm., 182, 33-39.
8. Kunastitchai, S., Pichert, L., Sarisuta, N., & Müller, B. W. (2006). Application of aerosol solvent extraction system (ASES) process for preparation of liposomes in a dry and reconstitutable form. Int. J. Pharm., 316, 93-101.
9. Lucien, F. P., & Foster, N. R. (2000). Solubilities of solid mixtures in supercritical carbon dioxide: a review. J. Supercrit. Fl., 17, 111-134.
10. Magnan, C., Badens, E., Commenges, N., & Charbit, G. (2000). Soy lecithin micronization by precipitation with a compressed fluid antisolvent - influence of process parameters. J. Supercrit. Fl., 19, 69-77.
11. Müller, B. W., & Fischer, W. (1989). Verfahren zur Herstellung einer mindestens einen Wirkstoff und einen Träger umfassenden Zubereitung. German Patent Appl. No. DE 3744329.
12. Reverchon, E. (1999). Supercritical antisolvent precipitation of micro- and nano-particles. J. Supercrit. Fl., 15, 1-21.
13. Reverchon, E., & Della Porta, G. (1999). Production of antibiotic micro- and nano-particles by supercritical antisolvent precipitation. Powder Technol., 106, 23-29.
14. Ruchatz, F., Kleinebudde, P., & Müller, B. W. (1997). Residual solvents in biodegradable microparticles. Influence of process parameters on the residual solvent in microparticles produced by the aerosol solvent extraction system (ASES) process. J. Pharm. Sci., 86(1), 101-105.
15. Steckel, H., Thies, J., & Müller, B. W. (1997). Micronizing of steroids for pulmonary delivery by supercritical carbon dioxide. Int. J. Pharm., 152, 99-110.
16. Sze Tu, L., Dehghani, F., & Foster, N. R. (2002). Micronisation and microen-capsulation of pharmaceuticals using a carbon dioxide antisolvent. Powder Technol., 126, 134-149.
17. Theeuwes, F., Hussain, A., & Higuchi, T. (1974). Quantitative analytical method for determination of drugs dispersed in polymers using differential scanning calorimetry. J. Pharm. Sci., 63(3), 427-429.
18. Thiering, R., Dehghani, F., & Foster, N. R. (2001). Current issues relating to anti-solvent micronisation techniques and their extension to industrial scales. J. Supercrit. Fl., 21, 159-177.
19. Young, T. J., Johnston, K. P., Mishima, K., & Tanaka, H. (1999). Encapsulation of lysozyme in a biodegradable polymer by precipitation with a vaporover-liquid antisolvent. J. Pharm. Sci., 88(6), 640-650.