Heterocyclic aryl(phenyl) acetic acid and aryl acetohydroxamic acids as antiinflammatory - Antioxidant agents and inhibitors of lipoxygenase and serine proteases

Medicinal Chemistry

Volumn 3, Issue 5, 2007, Pages 439-445

  Michaelidou, A ^a   Hadjipavlou Litina, D ^a   Matsini, I ^a   Tsitsogianni, E ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Anti inflammatory agents; Antioxidant agents; Heterocyclic aryl acetic; Hydroxamic acids; Lipoxygenase inhibitors; Serine protease inhibitors

Indexed keywords

2 N HYDROXY 3 (2 OXO 2H CHROMEN 7 YL) 2 PHENYLACRYLAMIDE; 3 (1H INDOL 5 YL) 2 PHENYLACRYLAMIDE; 3 (1H INDOL 5 YL) 2 PHENYLACRYLIC ACID; 3 (2 OXO 2H CHROMEN 7 YL) 2 PHENYLACRYLIC ACID; ACETOHYDROXAMIC ACID; ANTIINFLAMMATORY AGENT; ANTIOXIDANT; ARYLACETIC ACID DERIVATIVE; CAFFEIC ACID; CARRAGEENAN; HETEROCYCLIC COMPOUND; INDOMETACIN; INOGATRAN; LIPOXYGENASE; LIPOXYGENASE INHIBITOR; NORDIHYDROGUAIARETIC ACID; SALICYLATE SODIUM; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; TRYPSIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; LIPOPHILICITY; MALE; NONHUMAN; PAW EDEMA; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; SOYBEAN; SPECTROSCOPY; STRUCTURE ANALYSIS; THIN LAYER CHROMATOGRAPHY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; LIPID PEROXIDATION; LIPOXYGENASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PHENYLACETATES; RATS; SERINE PROTEINASE INHIBITORS;

EID: 34648813229     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340607781745456     Document Type: Article

References (42)

1. Hilbers, P.M.; Rossi, A.; Finazzi-Agro, A.; Veldink, G.A.; Vliegenthart, F.G.J. Biochim. Biophys. Acta, 1994, 1211, 239.
2. Stallings, C.W.; Kroa, B.A.; Carroll, R.T.; Mertzer, A.L.; Funk, M.O. J. Mol. Biol., 1990, 211, 685.
3. Boyington, J.C.; Amzel, L.M. J. Biol. Chem., 1990, 165, 12771.
4. Veldink, G.A.; Vliegenthart, J.F.G. Adv. Inorg. Biochem., 1984, 6, 139.
5. Nelson, M.J.; Seitz, S.P. Curr. Opin. Struct Biol. 1994, 4, 878.
6. Solomon, E.I.; Zhou, J.; Neese, F.; Pavel, E.G. Chem. Biol., 1997, 4, 795.
7. Pontiki, E.; Hadjipavlou-Litina D. Med. Chem. 2006, 2(3), 251.
8. Flower, R.J.; Moncada, S.; Vane, J.R. Goodman and Gilman's the pharmacological Basis of Therapeutics, 7th edition, MacMilan, New York, 1985; pp. 695.
9. Moore, P.F.; Larson, D.L.; Otterness, L.G.; Weissman, A.; Kadin, S.B.; Sweeney, F.J.; Eskara, J.D.; Nagahisa, A.; Sakakibara, M.; Carty, T.J. Inflamm. Res., 1996, 45, 54.
10. Misra, U.; Hitkari, A.; Saxena, A.K.; Gurtu, S.; Shankar, K. Eur. J. Med. Chem., 1996, 31, 629.
11. Andreani, A.; Rambaldi, Locatelli, A.; Pifferi, G. Eur. J. Med. Chem., 1994, 29, 903.
12. Eheid Mohamad, Y.; Lashine Sayed, L. M.; El-Adl Sobhy, M.; Abou Kull Mansour, E. Zagazig J. Pharm. Sci., 1994, 3, 40.
13. El-Gendy, A.; Adel, A.; Abdou Naida, Z.; Sarhan El-Taher; El-Banna Hosny. A. Alexandria J. Pharm. Sci., 1993, 7, 99.
14. Kumar, A.; Saxena, K.K.; Gurtu, S.; Sinha, J.N.; Shanker, K. Indian Drugs, 1986, 24, 1.
15. Dandia, A. ; Sehgal, V.; Singh, P. Indian J. Chem., 1993, 32B,. 1288.
16. Pignatello, R.; Mazzone, S.; Panico, A.M.; Mazzone, G.; Penissi, G.; Castano, R.; Matera, M.; Blandino, G. Eur. J. Med. Chem., 1991, 26, 929.
17. Piller, N.B.; Casley-Smith, J.R. Br. J. Exp. Pathol., 1975, 56, 439.
18. Fylaktakidou, K.; Hadjipavlou-Litina, D.; Litinas, K.; Nicolaides, D. Cur. Pharm. Des., 2004, 30, 3813.
19. Neichi, T.; Koshihara, Y.; Mutora, S.I. Biochim. Biophys. Acta, 1983, 753, 130.
20. Kimura, Y.; Okuda, H.; Arichi, S.; Baba, K.; Kozawa, M. Biochim. Biophys. Acta, 1985, 834, 224.
21. Craven, P.A.; Pfanstiel, J.; De Rubertis F.R. J. Clin. Invest., 1986, 77, 850.
22. Ozaki, Y.; Ohashi, T.; Niwa, Y. Biochem. Pharmacol., 1986, 33, 3481.
23. Paya, M.; Halliwell, B.; Hoult, J.R.S. Biochem. Pharmacol., 1992, 44, 205.
24. Mora, A.; Paya, M.; Rios, J.L.; Alcaraz, M.J. Biochem. Pharmacol., 1990, 40, 793.
25. Vollhardt, K.R.; Schore, N.E. In: Organic Chemistry, Freeman, W.H and Company ed, 2d edition, 1994; pp. 399.
26. Hansch, C.; Leo, A.J. In: Exploring QSAR Fundamentals and applications in Chemistry and Biology, Heller, S.R. ed. ACS Professional Reference Book, Washington, D.C. 1995, Chapter 7, I, pp. 279-280.
27. Biobyte Corp., C-QSAR Database 201 West 4th Str., Suite 204, Claremont CA, California 91711, USA.
28. Shen T.Y. In: Burger's Medicinal Chemistry, Non steroidal anti-inflammatory agents, Wolf, M.E., Ed. John Wiley and Sons, New York, 1980; pp. 1217-1219.
29. Winter, C.A. En: Gattini, S and Dukes, M.N.G., Eds., Non-steroidal Anti-inflammatory Drugs Excepta Medica, Amsterdam, 1965; pp. 190.
30. Kuroda, T.; Suzuki, F.; Tamura, T.; Ohmori, K.; Hosoe, H. J. Med. Chem., 1992, 1130.
31. Muller, K. Archiv. Phar., 1994, 327, 3.
32. Kemal, C.; Louis-Flamberg, P.; Krupinski-Olsen, R.; Shorter, A.L. Biochemistry, 1987, 26, 7064.
33. Van der Zee, J.; Elimg, T.E.; Mason, R.P. Biochemistry, 1988, 32, 171.
34. a) Summers, J.B.; Mazdiyasni, Hormoz; Holms, J.H.; Ratajczyk, J.D.; Dyer, R.D.; Carter, G.W. J. Med. Chem., 1987, 30, 574;
35. b) Summers, J.B.; Gunn, B.P.; Martin, J.G., Martin, M.B.; Mazdiyasni, H.; Stewart, A.O.; Young, P.R.; Bouska, J.B.; Goetze, A.M.; Dyer, R.D.; Brooks, D.W.; Carter, G.W. J. Med. Chem., 1988, 31, 1960.
36. Pontiki E.; Hadjipavlou-Litina, D. Med. Res. Rev., 2006, in press.
37. (a) Pontiki E. and Hadjipavlou-Litina, D. Internet Electron. J. Mol. Des. 2002, 1, 134,
38. (b) Pontiki, E. and Hadjipavlou-Litina D. Mini Rev. Med. Chem., 2003, 3, 487.
39. Pontiki, E.; Hadjipavlou-Litina D. Curr. Med. Chem., 2004, 3, 139.
40. Rekker R. Hydrophobic Fragmentalt constant, Elsevier Eds., Scintific Co, 1977, 1, 19.
41. Kontogiorgis, C.; Hadjipavlou-Litina, D. J. Enz. Inhib. Med. Chem., 2003, 18, 63.
42. Prasa, D.; Svendsen, L.; Starzebecher, J. Thromb. Haemost., 1997, 78, 1215.