La polypose juvénile infantile serait causée par une délétion de la région 10q23 comprenant les deux gènes suppresseurs de tumeurs bmpr1a et pten

Medecine/Sciences

Volumn 22, Issue 11, 2006, Pages 912-913

  Delnatte, Capucine ^a,b   Stoppa Lyonnet, Dominique ^a   Mougenot, Jean François ^c  

^a INSTITUT CURIE   (France)

^b HOSPICES CIVILS DE LYON   (France)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ARTICLE; CHROMOSOME 10; CHROMOSOME MAP; COLON POLYPOSIS; FLUORESCENCE IN SITU HYBRIDIZATION; GENE DELETION; GENETICS; HUMAN; INFANT; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; TUMOR SUPPRESSOR GENE;

ADENOMATOUS POLYPOSIS COLI; BASE SEQUENCE; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE I; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 10; GENE DELETION; GENES, TUMOR SUPPRESSOR; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INFANT; MOLECULAR SEQUENCE DATA; PTEN PHOSPHOHYDROLASE;

EID: 34548857313     PISSN: 07670974     EISSN: 19585381     Source Type: Journal    
DOI: 10.1051/medsci/20062211912     Document Type: Article

References (10)

1. Howe JR, Mitros FA, Summers RW. The risk of gastrointestinal carcinoma in familial juvenile polyposis. Ann Surg Oncol 1998; 5: 751-6.
2. Sachatello CR, Griffen WO Jr. Hereditary polypoid diseases of the gastrointestinal tract: a working classification. Am J Surg 1975; 129: 198-203.
3. Howe JR, Sayed MG, Ahmed AF, et al. The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. J Med Genet 2004; 41:484-91.
4. Delnatte C, Sanlaville D, Mougenot JF, et al. Contiguous gene deletion within chromosome arm 10q is associated with juvenile polyposis of infancy, reflecting cooperation between the BMPR1A and PTEN tumor-suppressor genes. Am J Hum Genet 2006; 78: 1066-74.
5. Dehainault C, Lauge A, Caux-Moncoutier V, et al. Multiplex PCR/liquid chromatography assay for detection of gene rearrangements: application to RB1 gene. Nucleic Acids Res 2004; 32: e139.
6. Waite KA, Eng C. BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels. Hum Mol Genet 2003; 12:679-84.
7. He XC, Zhang J, Tong WG, et al. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet 2004; 36: 1117-21.
8. Gregorieff A, Clevers H. Wnt signaling in the intestinal epithelium: from endoderm to cancer. Genes Dev 2005; 19: 877-90.
9. Salviati L, Patricelli M, Guariso G, et al. Deletion of PTEN and BMPR1A on chromosome 10q23 is not always associated with juvenile polyposis of infancy. Am J Hum Genet 2006; 79: 593-6.
10. Sanlaville D, Delnatte C, Mougenot JF, et al. Reply to Salviati et al. Am J Hum Genet 2006; 79: 596-7