Determination of cilnidipine, a new calcium antagonist, in human plasma using high performance liquid chromatography with tandem mass spectrometric detection

Analytica Chimica Acta

Volumn 600, Issue 1-2 SPEC. ISS., 2007, Pages 142-146

  Zhang, Xianhua ^a   Zhai, Suodi ^a   Zhao, Rongsheng ^a   Ouyang, Jin ^b   Li, Xiaoguang ^a   Baeyens, Willy R G ^c  

^a PEKING UNIVERSITY THIRD HOSPITAL   (China)

^b BEIJING NORMAL UNIVERSITY   (China)

^c GHENT UNIVERSITY   (Belgium)

Author keywords

Cilnidipine; High performance liquid chromatographic method coupled with tandem mass spectrometry (HPLC MS MS); Human plasma; Nimodipine

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IONS; MASS SPECTROMETRY; PHARMACOKINETICS; PLASMA (HUMAN); PROTEINS;

ANTAGONIST; CILNIDIPINE; INTERNAL STANDARD (IS); MULTIPLE REACTION MONITORING (MRM); NIMODIPINE; REVERSED-PHASE CHROMATOGRAPHIC SYSTEM; TURBOIONSPRAY (TIS);

CALCIUM;

CILNIDIPINE; NIMODIPINE;

ACCURACY; ADULT; ARTICLE; CALIBRATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; ELUTION; FREEZE THAWING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RELIABILITY; REVERSED PHASE LIQUID CHROMATOGRAPHY; ROOM TEMPERATURE; SENSITIVITY ANALYSIS; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION STUDY;

ADULT; CALCIUM; CALCIUM CHANNEL BLOCKERS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIHYDROPYRIDINES; HUMANS; MALE; TANDEM MASS SPECTROMETRY; TEMPERATURE;

EID: 34548826805     PISSN: 00032670     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aca.2006.11.072     Document Type: Article

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