Influence of pulsatile flow on LDL transport in the arterial wall

Annals of Biomedical Engineering

Volumn 35, Issue 10, 2007, Pages 1782-1790

  Sun, Nanfeng ^a   Wood, Nigel B ^a   Hughes, Alun D ^b   Thom, Simon A M ^b   Xu, X Yun ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Atherosclerosis; LDL transport; Lipid accumulation; Wall shear stress

Indexed keywords

BLOOD VESSELS; COMPUTER SIMULATION; HEMODYNAMICS; LIPIDS; PULSATILE FLOW; STEADY FLOW;

ATHEROSCLEROSIS; DISTRIBUTION PATTERNS; LIPID ACCUMULATION; PULSATILE FLOW SIMULATION; WALL SHEAR STRESS;

PROTEINS;

LOW DENSITY LIPOPROTEIN;

ACTIVE TRANSPORT; ANIMAL; ARTERY; ARTICLE; BIOLOGICAL MODEL; BLOOD PRESSURE; CAPILLARY PERMEABILITY; COMPUTER SIMULATION; HUMAN; METABOLISM; PHYSIOLOGY; PULSATILE FLOW;

ANIMALS; ARTERIES; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD PRESSURE; CAPILLARY PERMEABILITY; COMPUTER SIMULATION; HUMANS; LIPOPROTEINS, LDL; MODELS, CARDIOVASCULAR; PULSATILE FLOW;

EID: 34548826759     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-007-9347-1     Document Type: Article

References (37)

1. Ai, L., Vafai, K. (2006) A coupling model for macromolecule transport in a stenosed arterial wall. Int. J. Heat. Mass Transfer 49:1568-1591
2. 14c-4-cholesterol between intra-luminal serum and artery wall in isolated dog common carotid artery. J. Physiol. Lond. 233:37P-38P
3. 14c-4-cholesterol between perfusing serum and dog common carotid artery: a shear dependent process. Cardiovasc. Res. 8:194-203
4. Caro, C. G., Fitz-Gerald, J. M., Schroter, R. C.(1971) Atheroma and arterial wall shear observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis. Proc. R. Soc. Lond. Ser. B Biol. Sci. 177:109-159
5. 14c-4- cholesterol between serum and wall in the perfused dog common carotid artery. Circ. Res. 32:187-205
6. Colton, C. K., Friedman, S., Wilson, D. E., Lees, R. S. (1972) Ultrafiltration of lipoproteins through a synthetic membrane. Implications for the filtration theory of atherogenesis. J. Clin. Invest. 51:2472-2481
7. Curmi, P. A., Juan, L., Tedgui, A. (1990) Effect of transmural pressure on low density lipoprotein and albumin transport and distribution across the intact arterial wall. Circ. Res. 66:1692-1702
8. DeMaio, L., Chang, Y. S., Gardner, T. W., Tarbell, J. M., Antonetti, D. A. (2001) Shear stress regulates occludin content and phosphorylation. Am. J. Physiol. Heart Circ. Physiol. 281:H105-H113
9. Ethier, C. R. (2002) Computational modeling of mass transfer and links to atherosclerosis. Ann. Biomed. Eng. 30:461-471
10. Friedman, M. H., Fry, D. L. (1993). Arterial permeability dynamics and vascular disease. Atherosclerosis 104:189-194
11. Fry, D. L. (1968) Acute vascular endothelial changes associated with increased blood velocity gradient. Circ. Res. 22:165-197
12. Hillsley, M. V., Tarbell, J. M. (2002) Oscillatory shear alters endothelial hydraulic conductivity and nitric oxide levels. Biochem. Biophys. Res. Commun. 293:1466-1471
13. Hoff, H. F., Heideman, C. L., Jackson, R. L., Bayardo, R. J., Kim, H. S., Gotto, A. M. J. (1975) Localization patterns of plasma apolipoproteins in human atherosclerotic lesions. Circ. Res. 37:72-79
14. Karner, G., Perktold, K. (2000) Effect of endothelial injury and increased blood pressure on albumin accumulation in the arterial wall: A numerical study. J. Biomech. 33:709-715
15. Karner, G., Perktold, K., Zehentner, H. P. (2001) Computational modeling of macromolecule transport in the arterial wall. Comput. Methods Biomech. Biomed. Eng. 4:491-504
16. Kedem, O., Katchalsky, A. (1958) Thermodynamic analysis of the permeability of biological membranes to non-electrolytes. Biochem. Biophys. Acta 27:229-246
17. Long, Q., Xu, X. Y., Ramnarine, K. V., Hoskins, P. (2001) Numerical investigation of physiologically realistic pulsatile flow through arterial stenosis. J. Biomech. 34:1229-1242
18. Meyer, G., Merval, R., Tedgui, A. (1996) Effects of pressure-induced stretch and convection on low-density lipoprotein and albumin uptake in the rabbit aortic wall. Circ. Res.79:532-540
19. Ogunrinade, O., Kameya, G. T., Truskey, G. A. (2002) Effect of fluid stress on the permeability of the arterial endothelium. Ann. Biomed. Eng. 30:430-446
20. Ojha, M., Cobbold, R. S. C., Johnston, K. W., Hummel, R. L. (1989) Pulsatile flow through constricted tubes: an experimental investigation using photochromic tracer methods. J. Fluid Mech. 203:173-197
21. Pappenheimer, J. R., Renkin, E. M., Borrero, L. M. (1951) Filtration, diffusion and molecular sieving through peripheral capillary membranes. A contribution to the pore theory of capillary permeability. Am. J. Physiol. 167:13-45
22. Prosi, M. Computer Simulation von Massetransportvorgängen in Arterien. Ph.D. thesis, Technischen Universität Graz, 2003
23. Prosi, M., Zunino, P., Perktold, K., Quarteroni, A. (2005) Mathematical and numerical models for transfer of low-density lipoproteins through the arterial wall: a new methodology for the model set up with applications to the study of disturbed lumenal flow. J. Biomech. 38:903-917
24. Rappitsch, G., Perktold, K. (1996) Computer simulation of convective diffusion processes in large arteries. J. Biomech. 29:207-215
25. Rappitsch, G., Perktold, K. (1996) Pulsatile albumin transport in large arteries: a numerical simulation study. ASME J. Biomech. Eng. 118:511-519
26. Rappitsch, G., Perktold, K., Pernkopf, E. (1997) Numerical modelling of shear-dependent mass transfer in large arteries. Int. J. Numer. Methods Fluids 25:847-857
27. Ross, R. (1993) Atherosclerosis: a defense mechanism gone awry. Am. J. Pathol. 143:987-1002
28. Sill, H. W., Chang, Y. S., Artman, J. R., Frangos, J. A., Hollis, T. M., Tarbell, J. M. (1995) Shear stress increases hydraulic conductivity of cultured endothelial monolayers. Am. J. Physiol. Heart Circ. Physiol. 268:535-543
29. Stangeby, D. K., Ethier, C. R. (2002) Computational analysis of coupled blood-wall arterial LDL transport. ASME J. Biomech. Eng. 124:1-8
30. Stangeby, D. K., Ethier, C. R. (2002) Coupled computational analysis of arterial LDL transport - effects of hypertension. Comput. Methods Biomech. Biomed. Eng. 5:233-241
31. Sun, N., N. B. Wood, A. D. Hughes, S. A. M. Thom, and X. Y. Xu (2006) Fluid-wall modelling of mass transfer in an axisymmetric stenosis: effects of shear-dependent transport properties. Ann. Biomed. Eng. 34:1119 - 1128
32. Sun, N., N. B. Wood, A. D. Hughes, S. A. M. Thom, and X. Y. Xu. Effects of transmural pressure and wall shear stress on ldl accumulation in the arterial wall: a numerical study using a multi-layered model. Am. J. Physiol. Heart Circ. Physiol. 292:H3148-H3157, 2007
33. Tarbell, J. M. (2003) Mass transport in arteries and the localization of atherosclerosis. Annu. Rev. Biomed. Eng. 5:79-118
34. Wada, S., Karino, T. (1999) Theoretical study on flow-dependent concentration polarization of low density lipoproteins at the luminal surface of a straight artery. Biorheology 36:207-223
35. Wada, S., Karino, T. (2002) Theoretical prediction of low-density lipoproteins concentration at the luminal surface of an artery with a multiple bend. Ann. Biomed. Eng. 30:778-791
36. Wada, S., Koujiya, M., Karino, T. (2002) Theoretical study of the effect of local flow disturbances on the concentration of low-density lipoproteins at the luminal surface of end-to-end anastomosed vessels. Med. Biol. Eng. Comput. 40:576-587
37. Yang, N., Vafai, K. (2006) Modeling of low-density lipoprotein (LDL) transport in the artery-effects of hypertension. Int. J. Heat. Mass Transfer 49:850-867