Microsatellite abnormalities and somatic down-regulation of mismatch repair characterize nodular-trabecular muscle-invasive urothelial carcinoma of the bladder

Histopathology

Volumn 51, Issue 4, 2007, Pages 458-467

  Rubio, J ^b   Blanes, A ^b   Sanchez Carrillo, J J ^b   Diaz Cano, S J ^a,b  

^a KING S COLLEGE HOSPITAL   (United Kingdom)

^b HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

Author keywords

Bladder; Infiltration pattern; Kinetic; Microsatellite; Prognosis; Tumour suppressor gene; Urothelial carcinoma

Indexed keywords

KI 67 ANTIGEN; PROTEIN MLH1; PROTEIN MSH2; PROTEIN P53; RETINOBLASTOMA PROTEIN; WT1 PROTEIN;

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; BLADDER CARCINOMA; CANCER DIAGNOSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; DENATURING GRADIENT GEL ELECTROPHORESIS; FISHER EXACT TEST; GENE MUTATION; GENE SEQUENCE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MICROSATELLITE MARKER; MISMATCH REPAIR; NEUROFIBROMATOSIS; PLOIDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STATISTICAL SIGNIFICANCE; UROGENITAL TRACT CANCER;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; CARCINOMA, TRANSITIONAL CELL; CELL NUCLEUS; CELL PROLIFERATION; DNA MISMATCH REPAIR; DNA, NEOPLASM; HUMANS; MICROSATELLITE INSTABILITY; MIDDLE AGED; MUSCLE, SMOOTH; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NEUROFIBROMATOSIS 1; NUCLEAR PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEIN P53; URINARY BLADDER NEOPLASMS; UROTHELIUM; WT1 PROTEINS;

EID: 34548798070     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2007.02795.x     Document Type: Article

References (50)

1. Cohen MB, Waldman FM, Carroll PR, Kerschmann R, Chew K, Mayall BH. Comparison of five histopathologic methods to assess cellular proliferation in transitional cell carcinoma of the urinary bladder. Hum. Pathol. 1993 24 772 778.
2. Hierro Martin I, Alvarez Perez M, Blanes Berenguel A et al. Contribucion a la categorizacion de los CCT de vejiga, sistematizacion de la gradacion y utilidad de la ploidia de ADN. Actas Urol. Esp. 1999 23 489 496.
3. Jimenez RE, Gheiler E, Oskanian P et al. Grading the invasive component of urothelial carcinoma of the bladder and its relationship with progression-free survival. Am. J. Surg. Pathol. 2000 24 980 987.
4. Smits G, Schaafsma E, Kiemeney L, Caris C, Debruyne F, Witjes JA. Microstaging of pT1 transitional cell carcinoma of the bladder: identification of subgroups with distinct risks of progression. Urology 1998 52 1009 1013 discussion 1013 1004.
5. Younes M, Sussman J, True LD. The usefulness of the level of the muscularis mucosae in the staging of invasive transitional cell carcinoma of the urinary bladder. Cancer 1990 66 543 548.
6. Hermann GG, Horn T, Steven K. The influence of the level of lamina propria invasion and the prevalence of p53 nuclear accumulation on survival in stage T1 transitional cell bladder cancer. JUrol. 1998 159 91 94.
7. Diaz-Cano SJ, Blanes A, Rubio J, Matilla A, Wolfe HJ. Molecular evolution and intratumor heterogeneity by topographic compartments in muscle-invasive transitional cell carcinoma of the urinary bladder. Lab. Invest. 2000 80 279 289.
8. Baithun SI, Naase M, Blanes A, Diaz-Cano SJ. Molecular and kinetic features of transitional cell carcinomas of the bladder. Biological and clinical implications. Virchows Arch. 2001 438 289 297.
9. Pozo L, Camacho F, Rios-Martin JJ, Diaz-Cano SJ. Cell proliferation in skin tumors with ductal differentiation: patterns and diagnostic applications. JCutan. Pathol. 2000 27 292 297.
10. Diaz-Cano SJ, Garcia-Moliner M, Carney W, Wolfe HJ. Bcl-2 expression and DNA fragmentation in breast carcinoma, pathologic and steroid hormone receptors correlates. Diagn. Mol. Pathol. 1997 6 199 208.
11. Diaz-Cano SJ, de Miguel M, Blanes A, Tashjian R, Galera H, Wolfe HJ. Clonality as expression of distinctive cell kinetic patterns in nodular hyperplasias and adenomas of the adrenal cortex. Am. J. Pathol. 2000 156 311 319.
12. Salomon RN, Diaz-Cano S. Introduction to apoptosis. Diagn. Mol. Pathol. 1995 4 235 238.
13. Koch M, de Miguel M, Höfler H, Diaz-Cano SJ. Kinetic profiles of intraepithelial and invasive prostatic neoplasias: the key role of downregulated apoptosis in tumor progression. Virchows Arch. 2000 436 413 420.
14. Ro JY, Ayala AG, el-Naggar A. Muscularis mucosa of urinary bladder. Importance for staging and treatment. Am. J. Surg. Pathol. 1987 11 668 673.
15. van Diest PJ, Baak JP, Matze-Cok P et al. Reproducibility of mitosis counting in 2,469 breast cancer specimens: results from the Multicenter Morphometric Mammary Carcinoma Project. Hum. Pathol. 1992 23 603 607.
16. Harjacek M, Diaz-Cano S, Alman BA et al. Prominent expression of mRNA for proinflammatory cytokines in synovium in patients with juvenile rheumatoid arthritis or chronic lyme arthritis. JRheumatol. 2000 27 497 503.
17. Epstein JI, Amin MB, Reuter VR, Mostofi FK. The World Health Organization/International Society of Urological Pathology consensus classification of urothelial (transitional cell) neoplasms of the urinary bladder. Bladder Consensus Conference Committee. Am. J. Surg. Pathol. 1998 22 1435 1448.
18. Blanes A, Diaz-Cano SJ. DNA and kinetic heterogeneity during the clonal evolution of adrenocortical proliferative lesions. Hum. Pathol. 2006 37 1295 1303.
19. Blanes A, Sanchez-Carrillo JJ, Diaz-Cano SJ. Topographic molecular profile of pheochromocytomas: role of somatic down-regulation of mismatch repair. JClin. Endocrinol. Metab. 2006 91 1150 1158.
20. Diaz-Cano SJ, de Miguel M, Blanes A, Tashjian R, Galera H, Wolfe HJ. Clonal patterns in phaechromocytomas and MEN-2A adrenal medullary hyperplasias: histologic and kinetic correlates. JPathol. 2000 192 221 228.
21. Diaz-Cano SJ. Are PCR artifacts in microdissected samples preventable? Hum. Pathol. 2001 32 1415.
22. Diaz-Cano SJ, Blanes A, Wolfe HJ. PCR techniques for clonality assays. Diagn. Mol. Pathol. 2001 10 24 33.
23. Diaz-Cano SJ, Brady SP. DNA extraction from formalin-fixed, paraffin-embedded tissues: protein digestion as a limiting step for retrieval of high-quality DNA. Diagn. Mol. Pathol. 1997 6 342 346.
24. Cawkwell L, Lewis FA, Quirke P. Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction. Br. J. Cancer 1994 70 813 818.
25. Blanes A, Rubio J, Martinez A, Wolfe HJ, Diaz-Cano SJ. Kinetic profiles by topographic compartments in muscle-invasive transitional cell carcinomas of the bladder: role of TP53 and NF1 genes. Am. J. Clin. Pathol. 2002 118 93 100.
26. Diaz-Cano SJ. Designing a molecular analysis of clonality in tumours. JPathol. 2000 191 343 344.
27. Mutter GL, Boynton KA. X chromosome inactivation in the normal female genital tract: implications for identification of neoplasia. Cancer Res. 1995 55 5080 5084.
28. Diaz-Cano SJ. Clonality studies in the analysis of adrenal medullary proliferations. Application principles and limitations. Endocr. Pathol. 1998 9 301 316.
29. Diaz-Cano SJ, de Miguel M, Blanes A, Tashjian R, Wolfe HJ. Germline RET 634 mutation positive MEN 2A-related C-cell hyperplasias have genetic features consistent with intraepithelial neoplasia. JClin. Endocrinol. Metab. 2001 86 3948 3957.
30. Blanes A, Diaz-Cano SJ. Complementary analysis of microsatellite tumor profile and mismatch repair defects in colorectal carcinomas. World J. Gastroenterol. 2006 12 5932 5940.
31. Bibbo M, Bartels PH, Dytch HE, Wied GL. Cell image analysis. In Bibbo M ed. Comprehensive cytopathology. Philadelphia : Saunders Co., 1991 965 983.
32. Dressler LG. Controls, standards, and histogram interpretation in DNA flow cytometry. Meth. Cell. Biol. 1990 33 157 171.
33. Sherwood SW, Schimke RT. Cell cycle analysis of apoptosis using flow cytometry. Meth. Cell Biol. 1995 46 77 97.
34. Chen LC, Kurisu W, Ljung BM, Goldman ES, Moore DI, Smith HS. Heterogeneity for allelic loss in human breast cancer. JNatl Cancer Inst. 1992 84 506 510.
35. Deng G, Lu Y, Zlotnikov G, Thor AD, Smith HS. Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science 1996 274 2057 2059.
36. Diaz-Cano SJ, Wolfe HJ. Clonality in Kaposi's sarcoma [letter; comment]. N. Engl. J. Med. 1997 337 571 572.
37. Blanes A, Jimenez-Martin JJ, Miranda MT, Diaz-Cano SJ. Absence of the physiologic cellular kinetic balance and down-regulation of mlh1/msh2 characterize deep topographic compartments of colo-rectal adenocarcinomas. Lab. Invest. 2003 83 114A 115A (Abstract).
38. Jimenez JJ, Blanes A, Diaz-Cano SJ. Microsatellite instability in colon cancer. N. Engl. J. Med. 2003 349 1774 1776 author reply 1774 1776.
39. Liang JT, Chang KJ, Chen JC et al. Clinicopathologic and carcinogenetic appraisal of DNA replication error in sporadic T3N0M0 stage colorectal cancer after curative resection. Hepatogastroenterology 1999 46 883 890.
40. Thibodeau SN, French AJ, Cunningham JM et al. Microsatellite instability in colorectal cancer: different mutator phenotypes and the principal involvement of hMLH1. Cancer Res. 1998 58 1713 1718.
41. Jimenez-Martin JJ, Miranda MT, Blanes A, Diaz-Cano SJ. Expression of mlh1/msh2 in colo-rectal adenocarcinomas: SAGE/microarray profile and tumor phenotype. Lab. Invest. 2003 83 296A (Abstract).
42. Chapusot C, Martin L, Bouvier AM et al. Microsatellite instability and intratumoural heterogeneity in 100 right-sided sporadic colon carcinomas. Br. J. Cancer 2002 87 400 404.
43. Chapusot C, Martin L, Mungra N et al. Sporadic colorectal cancers with defective mismatch repair display a number of specific morphological characteristics: relationship between the expression of hMLH1 and hMSH2 proteins and clinicopathological features of 273 adenocarcinomas. Histopathology 2003 43 40 47.
44. Duval A, Hamelin R. Mutations at coding repeat sequences in mismatch repair-deficient human cancers: toward a new concept of target genes for instability. Cancer Res. 2002 62 2447 2454.
45. Peltomaki P. DNA mismatch repair and cancer. Mutat. Res. 2001 488 77 85.
46. Goel A, Arnold CN, Niedzwiecki D et al. Characterization of sporadic colon cancer by patterns of genomic instability. Cancer Res. 2003 63 1608 1614.
47. Cordon-Cardo C, Zhang ZF, Dalbagni G et al. Cooperative effects of p53 and pRB alterations in primary superficial bladder tumors. Cancer Res. 1997 57 1217 1221.
48. Cote RJ, Dunn MD, Chatterjee SJ et al. Elevated and absent pRb expression is associated with bladder cancer progression and has cooperative effects with p53. Cancer Res. 1998 58 1090 1094.
49. Furth ME, Aldrich TH, Cordon-Cardo C. Expression of ras proto-oncogene proteins in normal human tissues. Oncogene 1987 1 47 58.
50. Aaltonen V, Bostrom PJ, Soderstrom KO et al. Urinary bladder transitional cell carcinogenesis is associated with down-regulation of NF1 tumor suppressor gene in vivo and in vitro. Am. J. Pathol. 1999 154 755 765.